Pathophysiology of hepatic insufficiency

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Abstract

The liver is a unique and complex functioning organ, which is central in the metabolism of proteins, carbohydrates, fats and plays an important role in digestion, hematopoiesis, hemocoagulation, and detoxification processes. The pathology of the liver is complex and diverse, often accompanied by the pathology of other organs. Liver diseases are often encountered by doctors of various specialties, and for the clinician, knowledge of this pathology of this organ is essential. Currently, there is a steady increase in the number of patients with liver diseases, mostly people of working age. The development of acute and chronic liver pathology in the vast majority of cases is accompanied by the occurrence of various complications, up to the appearance of liver failure.

The lecture contains up-to-date information about the etiology and pathogenesis of hepatic pathology. Pathological processes in the liver are considered taking into account the complexity of its structural and functional organization. The main symptoms and syndromes of liver pathology are described, their pathophysiological assessment is given. Modern classifications of jaundice, hepatitis, liver failurea regiven.

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About the authors

Tatyana V. Brus

St. Petersburg State Pediatric Medical University

Author for correspondence.
Email: bant.90@mail.ru

PhD, MD, Associate Professor of the Department of Pathological Physiology with a Class of Immunopathology

Russian Federation, Saint Petersburg

Vladimir A. Evgrafov

St. Petersburg State Pediatric Medical University

Email: psh_k@mail.ru

PhD, MD, Associate Professor of the Department, of Anesthesiology, Resuscitation and Emergency Pediatrics

Russian Federation, Saint Petersburg

References

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Supplementary files

Supplementary Files
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1. Fig. 1. Ethanol metabolism in the liver. 1 — endogenous cholesterol synthesis; 2 — NADH reduction. MEOS — microsomal ethanol-oxidizing system; CoA — coenzyme A; HMG-CoA — 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase; AMP + 2Р — adenosine monophosphate + 2 phosphate; ATP — adenosine triphosphate

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2. Fig. 2. General pathogenesis of liver failure

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3. Fig. 3. Metabolism of bilirubin

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Copyright (c) 2022 Brus T.V., Evgrafov V.A.

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