Community-acquired pneumonia in children. The modern features
- Authors: Sergeeva E.V1, Petrova S.I1
-
Affiliations:
- St Petersburg State Pediatric Medical University Ministry of Health of the Russian Federation
- Issue: Vol 7, No 3 (2016)
- Pages: 5-10
- Section: Articles
- URL: https://journals.eco-vector.com/pediatr/article/view/5716
- DOI: https://doi.org/10.17816/PED735-10
- ID: 5716
Cite item
Abstract
Acute respiratory infections are one of the most frequent diseases among children and teenagers around the World. Pneumonia which caused by infectious agents is dangerous disease of the lower respiratory tract that can lead to the death. The continuing high level of morbidity and mortality causes the issue. The article describes the WHO criteria for the diagnosis of community-acquired pneumonia (CAP) and CAP severity indicators, also radiographic signs of CAP and modern epidemiological data. The etiological structure of CAP has age-specific peculiarities. Streptococcus pneumoniae (S. pneumoniae) is leading causative agent of CAP, it causes invasive and non-invasive forms of pneumonia. The role of atypical pathogens (Mycoplasma pneumoniae, Chlamydophila pneumoniae) and viruses was mentioned. The etiology of CAP may vary depending on geographic area, vaccination coverage, using antibiotics. The modern methods for identification of S. pneumoniae were itemized in the article. The own identification from blood lytA gene and cpsA gene S. pneumoniae by polymerase chain reaction (PCR) frequency data was presented. Among examined patients who were hospitalized in clinic SPbGPMU in 2011-2015 years attending preschool children less than 5 years of age prevailed (which accounted for 48%). The invasive form is revealed at 34% of the patients with CAP. In this group of patients course of the disease was severity, there was complications such as pneumothorax, pulmonary edema, and pleural exudation.
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About the authors
Evgeniya V Sergeeva
St Petersburg State Pediatric Medical University Ministry of Health of the Russian Federation
Author for correspondence.
Email: ev_sergeeva@bk.ru
Postgraduate Student. Pediatric Department No 2 (Pulmonology, Allergology) Russian Federation
Svetlana I Petrova
St Petersburg State Pediatric Medical University Ministry of Health of the Russian Federation
Email: dmsvetlana@yandex.ru
MD, PhD, Associate Professor. Department of Faculty Pediatrics Russian Federation
References
- Баранов А.А., Брико Н.И., Намазова-Баранова Л.С., Ряпис Л.А. Стрептококки и пневмококки: Руководство для врачей. – Ростов-на/Д: Феникс, 2013. [Baranov AA, Briko NI, Namazova-Baranova LS, Ryapis LA. Streptokokki i pnevmokokki. Rukovodstvo dlya vrachey. Rostov-na-Donu: Feniks; 2013. (In Russ).]
- Боронина Л.Г., Саматова Е.В. Верификация этиологии обострений хронических инфекционно-воспалительных заболеваний легких у детей // Педиатр. – 2014. – Т. 5. – № 3. – С. 9–15. [Boronina LG, Samatova EV. Verification etiology of chronic infectious-inflammatory pulmonary diseases exacerbations in children. Pediatr (St Petersburg). 2014;5(3):9-15. (In Russ).]
- Брико Н.И. Бремя пневмококковых инфекций и направления совершенствования эпидемиологического надзора в России // Эпидемиол. и инфекц. бол. Акт. вопр. – 2013. – С. 4–9. [Briko NI. The burden of Streptococcus pneumoniae infections and ways of improving epidemiological surveillance in Russia. Epidemiol. i infekts. bol. Akt. vopr. 2013:4-9. (In Russ).]
- Вишнякова Л.А., Никитина М.А., Петрова С.И., и др. Роль Streptococcus pneumoniae, Мycoplasma рneumoniae и Сhlamydia pneumoniae при внебольничной пневмонии у детей // Пульмонология. – 2005. – № 3. – С. 43–46. [Vishnyakova LA, Nikitina MA, Petrova SI, et al. Rol’ Streptococcus pneumoniae, Mycoplasma pneumoniae i Shlamydia pneumoniae pri vnebol’nichnoy pnevmonii u detey. Pul’monologiya. 2005;3:43-46. (In Russ).]
- Козлов Р.С. Пневмококки: прошлое, настоящее и будущее. –Смоленск: Смоленск. гос. мед. акад., 2005. [Kozlov RS. Pnevmokokki: Proshloe, nastoyashchee i budushchee. Smolensk: Smolensk. Gos. Med. Akad.; 2005. (In Russ).]
- Лобзин Ю.В., Сидоренко С.В., Харит С.М., и др. Серотипы Streptococcus pneumoniae, вызывающих ведущие нозологические формы пневмококковых инфекций // Журнал инфектологии. – 2013. – Т. 5. – № 4. – С. 35–41. [Lobzin YV, Sidorenko SV, Kharit SM, et al. Serotypes of Streptococcus pneumoniae causing leading nosological forms of pneumococcal infections. Zhurnal Infektologii. 2013;5(4):35-41. (In Russ).]
- Никитина М.А., Петрова С.И., Вишнякова Л.А. Особенности клинического течения внебольничной пневмонии у детей на фоне хламидийной инфекции // Рос. вестник перинатологии и педиатрии. – 2004. – Т. 49. – № 4. – С. 47–50. [Nikitina MA, Petrova SI, Vishnyakova LA. Osobennosti klinicheskogo techeniya vnebol’nichnoy pnevmonii u detey na fone khlamidiynoy infektsii. Ros. vestnik perinatologii i pediatrii. 2004;49(4):47-50. (In Russ).]
- Сидоренко С.В., Лобзин Ю.В., Харит С.М., и др. Пневмококковая инфекция и современные возможности ее профилактики — эпидемиологический обзор ситуации в мире и в России // Вопросы современной терапии. – 2010. – Т. 9. – № 1. – С. 54–61. [Sidorenko SV, Lobzin YV, Kharit SM, et al. Pnevmokokkovaya infektsiya i sovremennye vozmozhnosti ee profilaktiki – epidemiologicheskiy obzor situatsii v mire i v Rossii. Voprosy sovremennoy terapii. 2010;9(1):54-61. (In Russ).]
- Чучалин А.Г., ред. Внебольничная пневмония у детей: распространенность, диагностика, лечение и профилактика: Научно-практическая программа. – М.: Оригинал-макет, 2011. [Chuchalin AG, red. Vnebol’nichnaya pnevmoniya u detey: rasprostranennost’, diagnostika, lechenie i profilaktika: Nauchno-prakticheskaya programma. Moscow: Original-maket; 2011 Tatochenko V. K. Klinicheskie rekomendatsii. Pediatriya (Pnevmoniya u detey). Ed by A.A. Baranova. Moscow: GEOTAR-Media; 2005. (In Russ).]
- Таточенко В. К. Клинические рекомендации. Педиатрия (Пневмония у детей) / под ред. А.А. Баранова. – М.: ГЭОТАР-Медиа, 2005. [Tatochenko VK. Klinicheskie rekomendacii. Pediatrija (Pnevmonija u detej). Ed by A.A. Baranova. Moscow: GJeOTAR-Media; 2005. (In Russ).]
- Alonsodevelasco Afmv EJ, Verhoef, Snippe H. Streptococcus pneumoniae: Virulence factors, pathogenesis, and vaccines. Microbiological Reviews. 1995:591-603.
- BTS Guidelines for the Management of Community Acquired Pneumonia in Childhood. Thorax. 2002;57:1-24. doi: 10.1136/thorax.57.1.1.
- Direct and indirect effects of routine vaccination of children with 7-valent pneumococcal conjugate vaccine on incidence of invasive pneumococcal disease – United States, 1998-2003; Centers for Disease C, Prevention. 2005. MMWR Morb Mortal Wkly Rep. 54:893-7.
- Cevey-Macherel M, Galetto-Lacour A, Gervaix A, et al. Etiology of community-acquired pneumonia in hospitalized children based on WHO clinical guidelines. Eur J Pediatr. 2009;168:1429-36. doi: 10.1007/s00431-009-0943-y.
- Esposito S, Marches, A, Tozzi A. Bacteremic pneumococcal community-acquired pneumonia in children less than 5 years of age in Italy. Pediatric Infectious Disease J. 2012;7:705-710. doi: 10.1097/INF.0b013e31825384ae.
- Jain S, Williams DJ, Arnold SR, et al. Community-acquired pneumonia requiring hospitalization among U.S. children. N Engl J Med. 2015;372:835-454. doi: 10.1056/NEJMoa1405870.
- Jefferson T, Ferroni E, Curtale F, et al. Streptococcus pneumoniae in western Europe: serotype distribution and incidence in children less than 2 years old. The Lancet Infectious Diseases. 2006;6:405-10. doi: 10.1016/S1473-3099(06)70520-5.
- Jodar L, Butler J, Carlone G, et al. Vaccine. 2003;21(23): 3265-3272. doi: 10.1016/S0264-410X(03)00230-5.
- Mayanskiy N, Alyabieva N, Ponomarenko O, et al. Serotypes and antibiotic resistance of non-invasive Streptococcus pneumoniae circulating in pediatric hospitals in Moscow, Russia. Int J Infect Dis. 2014;20:58-62. doi: 10.1016/j.ijid.2013.11.005.
- Patria MF, Longhi B, Lelii M, et al. Association between radiological findings and severity of community-acquired pneumonia in children. Ital J Pediatr. 2013;39(1):56. doi: 10.1186/1824-7288-39-56.
- Pneumonia hospitalizations among young children before and after introduction of pneumococcal conjugate vaccine — United States, 1997-2006. MMWR. 2009;58(1):1-4.
- Resti M, Moriondo M, Cortimiglia M, et al. Community-acquired bacteremic pneumococcal pneumonia in children: diagnosis and serotyping by real-time polymerase chain reaction using blood samples. Clin Infect Dis. 2010;51:1042-1049. doi: 10.1086/656579.
- Sazawal S, Black RE. Effect of pneumonia case management on mortality in neonates, infants, and preschool children: a meta-analysis of community-based trials. The Lancet Infectious Diseases. 2003;3: 547-56. doi: 10.1016/S1473-3099(03)00737-0.
- Scott JA, Wonodi C, Moisi JC, et al. The definition of pneumonia, the assessment of severity, and clinical standardization in the Pneumonia Etiology Research for Child Health study. Clin Infect Dis. 2012;54(2): 109-116. doi: 10.1093/cid/cir1065.
- van Hoek AJ, Andrews N, Waight PA, et al. Effect of serotype on focus and mortality of invasive pneumococcal disease: coverage of different vaccines and insight into non-vaccine serotypes. PLoS One. 2012;7:39150. doi: 10.1371/journal.pone.0039150.
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