Microchimerism in children with perinatal pathology

Natalia A Treskina; Трескина Наталья Альбертовна; Anastasia P Polyakova; Полякова Анастасия Павловна; Olga Ya Volkova; Волкова Ольга Ярославовна; Vladimir E Vasiliev; Васильев Владимир Егорович; Yuriy V Petrenko; Петренко Юрий Валентинович; Dmitriy O Ivanov; Иванов Дмитрий Олегович

doi:10.17816/PED7398-103

Microchimerism in children with perinatal pathology

Authors: Treskina N.A¹, Polyakova A.P¹, Volkova O.Y.¹, Vasiliev V.E¹, Petrenko Y.V², Ivanov D.O²
Affiliations:
1. Federal Almazov North-West Medical Reserch Centre
2. St Petersburg State Pediatric Medical University
Issue: Vol 7, No 3 (2016)
Pages: 98-103
Section: Articles
URL: https://journals.eco-vector.com/pediatr/article/view/5730
DOI: https://doi.org/10.17816/PED7398-103
ID: 5730

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Abstract

The article presents the opportunity to identify the phenomenon of microchimerism in the genes of HLA loci A, B, C, DRB1, DQB1 by PCR-SSP. The sample group consists of the mothers and newborns with intrauterine growth retardation (IUGR) (20 pairs), hemolytic disease of the newborn (HDN) (21 pairs), after external rotation of the fetus (11 pairs), from women with malignancy (1 pair), autoimmune thrombocytopenia (1 pair), tuberous sclerosis (1 pair), bradyarrhythmias (1 pair). The control group consists of 13 pairs. Of the 138 studied blood samples microchimerism was detected in 33.9 % of patients and in 19.2 % of control group. Maternal microchimerism was found only in patients with perinatal pathology and was not met in the control group. Fetal microchimerism was distributed in all studied groups, but among patients with perinatal pathology, it was met three times more frequent than in the control group (23.9 % and 7.7 %, respectively). Significantly more frequent microchimerism was found in the group of patients with HDN than in the control (p = 0.04). In the other groups the occurrence of the chimeric gene from the control group was not statistically significant

Keywords

microchimerism, typing of HLA system by PCR SSP

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References

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Microchimerism in children with perinatal pathology

Full Text

Abstract

Keywords

Full Text

About the authors

Natalia A Treskina

Anastasia P Polyakova

Olga Ya Volkova

Vladimir E Vasiliev

Yuriy V Petrenko

Dmitriy O Ivanov

References

Supplementary files