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Influence of transforming growth factor-β on endothelial dysfunction in children with arterial hypertension
- Authors: Revenko N.A.1, Kaladze N.N.1, Aleshina O.K.1, Revenko O.A.1, Polonevich T.V.1
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Affiliations:
- S.I. Georgievsky the Order of the Red Banner of Labor Medical Institute, V.I. Vernadsky Crimean Federal University
- Issue: Vol 15, No 2 (2024)
- Pages: 31-42
- Section: Original studies
- URL: https://journals.eco-vector.com/pediatr/article/view/636238
- DOI: https://doi.org/10.17816/PED15231-42
- ID: 636238
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Abstract
BACKGROUND: Chronic non-communicable cardiovascular diseases, including hypertension, started in childhood and adolescence. The presence and severity of early arterial changes is associated with the presence and severity of standard risk factors. Structural and functional disorders of the vascular bed in hypertension are represented by dysfunction of the compensatory dilating ability of the endothelium, a violation of the thickness of the intima-media complex of the common carotid arteries and a violation of the humoral, metabolic and myogenic regulation of vascular tone.
AIM: To assess the severity of endothelial dysfunction and determine the significance of transforming growth factor-β (TGF-β) and endothelin-1 (ET-1) in its development in children with hypertension and metabolic syndrome.
Materials and methods: 122 children with hypertension were examined. Along with a complete clinical, laboratory and instrumental examination, the concentration of TGF-β and ET-1 in the blood serum was determined.
RESULTS: It was found that endothelial dysfunction was detected in children with hypertension, most pronounced in children with hypertension and metabolic disorders, the level of which increases with stabilization of the disease. Assessment is given as to possible development and progression of the disease and its favorable course depending on the dynamics of TGF-β profiles. Positive statistically significant correlations were obtained between the level of ET-1 and body mass index, waist circumference, blood pressure, and disease duration.
CONCLUSIONS: The revealed results suggest that endothelial dysfunction in children with hypertension is involved in the formation and progression of hypertension and metabolic syndrome against the background of chronic inflammation processes.
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About the authors
Natalya A. Revenko
S.I. Georgievsky the Order of the Red Banner of Labor Medical Institute, V.I. Vernadsky Crimean Federal University
Author for correspondence.
Email: shagal-75@mail.ru
ORCID iD: 0000-0003-3218-3123
SPIN-code: 8958-0529
MD, PhD, Cand. Sci. (Medicine), Associate Professor, Department of Pediatrics with a childhood infectious diseases course
Russian Federation, Lenin Blvd., 5/7, 295051, Simferopol, Republic of CrimeaNikolai N. Kaladze
S.I. Georgievsky the Order of the Red Banner of Labor Medical Institute, V.I. Vernadsky Crimean Federal University
Email: evpediatr@rambler.ru
ORCID iD: 0000-0002-4234-8801
SPIN-code: 5133-3829
MD, PhD, Dr. Sci. (Medicine), Professor, Head, Pediatrics Department of Pediatrics, Physiotherapy and Health Resorts Faculty of Postgraduate Education
Russian Federation, Lenin Blvd., 5/7, 295051, Simferopol, Republic of CrimeaOlga K. Aleshina
S.I. Georgievsky the Order of the Red Banner of Labor Medical Institute, V.I. Vernadsky Crimean Federal University
Email: laguna_15@mail.ru
ORCID iD: 0000-0002-3966-8310
SPIN-code: 8268-8809
MD, PhD, Cand. Sci. (Medicine), Associate Professor, Department of Pediatrics Propedeutics
Russian Federation, Lenin Blvd., 5/7, 295051, Simferopol, Republic of Crimea
Olga A. Revenko
S.I. Georgievsky the Order of the Red Banner of Labor Medical Institute, V.I. Vernadsky Crimean Federal University
Email: olgarevenko258@gmail.com
ORCID iD: 0000-0002-3960-2995
6th year student of the II Medical (Pediatric) Faculty, S.I. Georgievsky Order of the Red Banner of Labor Medical Institute
Russian Federation, Lenin Blvd., 5/7, 295051, Simferopol, Republic of CrimeaTatiana V. Polonevich
S.I. Georgievsky the Order of the Red Banner of Labor Medical Institute, V.I. Vernadsky Crimean Federal University
Email: tanyusha_polonevich@mail.ru
ORCID iD: 0009-0004-3634-438X
6th year student of the II Medical (Pediatric) Faculty
Russian Federation, Lenin Blvd., 5/7, 295051, Simferopol, Republic of CrimeaReferences
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