Email this article 
The effect of peptide bioregulators on the resistance of rats to cold-stress factor
- Authors: Ganapolsky V.P.1, Agafonov P.V.1, Matytsyn V.O.1,2
-
Affiliations:
- Kirov Military Medical Academy
- Academisian I.P. Pavlov First St. Petersburg State Medical University
- Issue: Vol 13, No 6 (2022)
- Pages: 85-96
- Section: Reviews
- URL: https://journals.eco-vector.com/pediatr/article/view/277318
- DOI: https://doi.org/10.17816/PED13685-96
- ID: 277318
Cite item
Open Access
Access granted
Abstract
BACKGROUND: Biologically active regulatory peptides are the drugs of new type that act selectively on targets, with having no significant side effects.
AIM: The aim of the study was to study the potential effect of peptide preparations Cortexin® and Semax® on the resistance of the rat organism to the cold stress factor in the model of cold stress maladaptation.
MATERIALS AND METHODS: White outbred male rats were injected intraperitoneally twice daily with placebo (n = 30), Cortexin® 5 mg/kg (n = 30) or Semax® 0.3 mg/kg (n = 30). Three days after the start of the injection course, the cold-stress effect was simulated in the climate chamber (Feutron, Germany) by cooling the air to 5°C at a relative humidity of 75–80%.
RESULTS: The use of RP significantly increased the duration of the rectal temperature plateau-period within 35°C (moderate hypothermia): in animals of the Cortexin® group from 10 days to 12 days, and in animals of the Semax® group, from 10 to 14 days. Cortexin® demonstrated moderate immunomodulatory properties, and Semax® had a more pronounced immunomodulatory effect. Both preparations showed a stress-protective effect. The use of regulatory peptides provided to delay the decrease in the rat general motor activity and exploratory behavior which develops under the influence of a simulated cold-stress factor. A slower rate of decrease in the swimming time of rats under the influence of regulatory peptides was registrated.
CONCLUSIONS: The meteoadaptogenic, stress-protective and nootropic effects of the regulatory peptides Cortexin® and Semax® were confirmed in rats on the model of cold-stress maladaptation.
Full Text
About the authors
Vyacheslav P. Ganapolsky
Kirov Military Medical Academy
Email: ganvp@mail.ru
MD, PhD, Dr. Sci. (Med.), Head of the Research Department of the Habitability, Research Center
Russian Federation, Saint PetersburgPavel V. Agafonov
Kirov Military Medical Academy
Author for correspondence.
Email: agafonov23@yandex.ru
MD, PhD, Cand. Sci. (Med.), Senior Lecturer at the Department of Military Field Therapy
Russian Federation, Saint PetersburgVyacheslav O. Matytsyn
Kirov Military Medical Academy; Academisian I.P. Pavlov First St. Petersburg State Medical University
Email: matitsin@list.ru
MD, PhD, Cand. Sci. (Med.), Senior Research Associate, Research Department of the Habitability, Research Center; Assistant Professor, Department of Normal Physiology
Russian Federation, Saint Petersburg; Saint PetersburgReferences
- Ashmarin IP, Eshchenko ND, Karazeeva EP. Neirokhimiya v tablitsakh i skhemakh. Moscow: Ekzamen; 2007. 143 p. (In Russ.)
- Ganapolskii VP, Agafonov PV, Matycin VO. Modeling of cold-stress disadaptation in rats to develop methods for its pharmacological correction. Russian Biomedical Research. 2022;7(1):3–15. (In Russ.) doi: 10.56871/2489.2022.64.64.001
- Karkishchenko NN, Karkishchenko VN, Shustov EB, et al. Biomeditsinskoe (doklinicheskoe) izuchenie lekarstvennykh sredstv, vliyayushchikh na fizicheskuyu rabotosposobnost’: Metodicheskie rekomendatsii. Moscow: FMBA Russia; 2017. 134 p. (In Russ.)
- Karkishchenko NN, Uiba VV, Karkishchenko VN, Shustov EB. Ocherki sportivnoi farmakologii. Vol 1. Vektory ekstrapolyatsii. N.N. Karkishchenko, V.V. Uiba, eds. Saint Petersburg: Aising; 2013. 288 p. (In Russ.)
- Kim AE, Shustov EB, Lemeshhenko AV, Cygan VN. Pathophysiological bases of maladjustment formation in high mountains and polar zones. Bulletin of the Russian Military Medical Academy. 2021;23(3): 215–222. (In Russ.) doi: 10.17816/brmma71182
- Novikov VS, Soroko SI, Shustov EB. Dezadaptatsionnye sostoyaniya cheloveka pri ekstremalnykh vozdeistviyakh i ikh korrektsiya. Saint Petersburg: Politekhnika-print; 2018. 548 p. (In Russ.)
- Osnovy gosudarstvennoi politiki Rossiiskoi Federatsii v Arktike na period do 2020 goda i dalneishuyu perspektivu. Rossiiskaya gazeta. Stolichnyi vypusk. 2009 March 27:4877(42). (In Russ.)
- Fisun AYa, Khalimov YuSh, Agafonov PV, et al. Features of the organization of therapeutic assistance to military personnel in the Arctic region. Military Medical Journal. 2019;341(3):73–75. (In Russ.)
- Chernikov OG, Kulnev SV, Kupriyanov SA, et al. Features of the organization of medical support for troops (forces) in the arctic zone. Military Medical Journal. 2020;341(4):4–12. (In Russ.)
- Shustov EB, Gasanov MT, Kapanadze GD, et al. Peptide bioregulation of resistance to extreme influences. Journal Biomed. 2018;(2):4–14. (In Russ.)
- Shustov EB, Kapanadze GD, Fokin JuV, Matveenko EL. Methodical features of biomedical research of the influence of pharmacological agents on the resistance of the organism to acute general hypothermia. Journal Biomed. 2017;(3):4–15. (In Russ.)
- Darenskaya NG, Ushakov IB, Ivanov IV, et al. Ekstrapolyatsiya eksperimentalnykh dannykh na cheloveka: printsipy, podkhody, obosnovanie metodov i ikh ispolzovanie v fiziologii i radiobiologii (Rukovodstvo). Moscow; Voronezh: Istoki; 2004. 232 p. (In Russ.)
Supplementary files
