Email this article 
IgE-hypersensitivity to allergens of the fungi Rhizopus Nigricans and Cladosporium Herbarum in childrenwith respiratory allergies
- Authors: Gurina O.P1, Dementeva E.A1, Blinov A.E1, Varlamova O.N1, Timokhina V.I1
-
Affiliations:
- St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
- Issue: Vol 7, No 4 (2016)
- Pages: 61-66
- Section: Articles
- URL: https://journals.eco-vector.com/pediatr/article/view/5969
- DOI: https://doi.org/10.17816/PED7461-66
- ID: 5969
Cite item
Open Access
Access granted
Abstract
A survey of 111 children diagnosed with respiratory allergies (allergic rhinitis, allergic bronchitis, obstructive bronchitis, recurrent bronchitis, bronchial asthma) aged 1 year to 17 years, of which 58 children have a diagnosis of atopic bronchial asthma of different severity. All children are at risk for the development of fungal sensitization, having a household contact with these allergens. Allergological diagnostics was performed by ELISA using a panel of pediatric and fungal (Rhizopus nigricans and Cladosporium herbarum) biotinylated allergens. As a result of the study revealed that allergens mold Rhizopus nigricans and Cladosporium herbarum are the causal significant factor in the development of respiratory allergies, including asthma, in children at risk. Most often a high level of hypersensivity to Rhizopus nigricans is seen in children aged 2-5 years, Cladosporium herbarum - aged 6-9 years, concomitant to both fungal allergens at the age of 10-17 years. The correlation between the severity of atopic process and degree of sensitization to fungal allergens was not detected. All children with atopic asthma have polyvalent sensitization. Allergens mold Rhizopus nigricans and Cladosporium herbarum must be taken into account in the preparation of a diagnostic panel for children with respiratory allergies at risk. It is necessary to support drug therapy of respiratory allergy in children the activities aimed at elimination of cause significant fungal sensitization everyday surroundings.
Full Text
About the authors
Olga P Gurina
St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Author for correspondence.
Email: ol.gurina@yandex.ru
MD, PhD, Senior Researcher, Research Center Russian Federation
Elena A Dementeva
St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: zorra2@yandex.ru
Junior researcher, Research Center Russian Federation
Aleksandr E Blinov
St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: aleks.blinov@mail.ru
Senior Researcher, Research Center Russian Federation
Olga N Varlamova
St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: ol.varlamova@bk.ru
Senior Researcher, Research Center Russian Federation
Vera I Timokhina
St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: vera-timokhina@bk.ru
MD, PhD, Senior Researcher, Research Center Russian Federation
References
- Бержец В.М., Коренева Е.А., Хлгатян С.В., и др. Выявление грибковой сенсибилизации у детей с атопическими заболеваниями // Медицинская иммунология. – 2011. – Т. 13. – № (4–5). – С. 349. [Berzhets VM, Koreneva EA, Khlgatyan SV, et al. Identification of fungal sensitization in children with atopic diseases. Meditsinskaya immunologiya. 2011;13(4-5):349. (In Russ.)]
- Бержец В.М., Хлгатян С.В., Коренева Е.А., и др. Изучение распространенности сенсибилизации к плесневым грибам у жителей Москвы и Московской области // Иммунопатология, аллергология, инфектология. – 2012. – Т. 3. – С. 18–22. [Berzhets VM, Khlgatyan SV, Koreneva EA, et al. The study of the prevalence of sensitization to mold fungi from residents of Moscow and Moscow region. Immunopatologiya, allergologiya, infektologiya. 2012;3:18-22. (In Russ.)]
- Гурина О.П., Дементьева Е.А., Блинов А.Е., и др. Особенности иммунного реагирования при атопии у детей // Педиатр. – 2014. – Т. 5. – № 4. – С. 95–104. [Gurina OP, Dement’eva EA, Blinov AE, et al. The peculiarities of immune response in atopy in children. Pediatr. 2014;5(4):95-104. (In Russ.)]
- Дьяков Ю.Т., ред. Ботаника: учебник. – М.: МГУ; 2007. [D’yakov YuT, ed. Botanika: uchebnik. Moscow: MGU; 2007. (In Russ.)]
- Козлова Я.И., Васильева Н.В., Чилина Г.А., и др. Микогенная аллергия у жителей помещений, пораженных микромицетами // Проблемы медицинской микологии. – 2008. – Т. 10. – № 2. – С. 17–21. [Kozlova YaI, Vasil’eva NV, Chilina GA, et al. Mycogenic allergy in inhabitants of areas affected by micromycetes. Problemy meditsinskoy mikologii. 2008;10(2):17-21. (In Russ.)]
- Козлова Я.И., Фролова Е.В., Филлипова Л.В., и др. Микогенная сенсибилизация у пациентов с бронхиальной астмой в Санкт-Петербурге // Медицинская иммунология. – 2015. – № 17. – С. 67. [Kozlova YaI, Frolova EV, Fillipova LV, et al. Mycogenic sensitization in patients with bronchial asthma in St Petersburg. Meditsinskaya immunologiya. 2015;(17):67. (In Russ.)]
- Митин Ю.А., Пастушенков В.Л., Углина О.А. Характеристика особенностей клинического течения, изменений иммунной системы у детей, больных острой дизентерией, имевших колонизацию кишечника грибами Aspergillus flavus // Медицинская иммунология. – 2015. – № 17. – С. 119–120. [Mitin YuA, Pastushenkov VL, Uglina OA. The characteristic features of clinical course, changes in immune system in children, patients with acute dysentery, which had colonization of gut fungi Aspergillus flavus. Meditsinskaya immunologiya. 2015;(17):119-120. (In Russ.)]
- Митрофанов В.С., Козлова Я.И. Плесени в доме (обзор) // Проблемы медицинской микологии. – 2004. – Т. 6. – № 2. – С. 10–18. [Mitrofanov VS, Kozlova YaI. Mold in the house (review). Problemy meditsinskoy mikologii. 2004;6(2):10-18. (In Russ.)]
- Мюллер Э., Лёффлер В. Микология: учебник. – М.: Мир, 1995. [Myuller E, Leffler V. Mikologiya: uchebnik. Moscow: Mir; 1995. (In Russ.)]
- Титова Н.Д. Комплексная диагностика различных вариантов микогенной аллергии при бронхиальной астме // Иммунопатология, аллергология, инфектология. – 2011. – № 3. – С. 101–108. [Titova ND. Complex diagnostic of different variants of mycogenic allergy in bronchial asthma. Immunopatologiya, allergologiya, infektologiya. 2011;(3):101-108. (In Russ.)]
- Титова Н.Д. Разнообразие механизмов микогенной аллергии при атопической бронхиальной астме // Астма. – 2011. – Т. 12. – № 1. – С. 5–10. [Titova ND. A variety of mechanisms mycogenic allergy in atopic bronchial asthma. Astma. 2011;12(1):5-10. (In Russ.)]
- Титова Н.Д., Новиков П.Д. Анализ микогенной сенсибилизации у больных бронхиальной астмой // Медицинская иммунология. – 2011. – Т. 13. – № 4–5. – С. 357. [Titova ND, Novikov PD. Analysis of mikogenic sensitization in patients with bronchial asthma. Meditsinskaya immunologiya. 2011;13(4-5):357. (In Russ.)]
- Fung F, Hunghson WG. Health effects of indoor fungal bioaerosol exposure. Appl Occup Environ Hyg. 2003;18 (7):535–544. doi: 10.1080/10473220301451.
- Mari A, Schneider P, Wally V. Sensitization to fungi: epidemiology, comparative skin tests, and IgE reactivity of fungal extracts. Clin Exp Allergy. 2003;33:
- -1438. doi: 10.1046/j.1365–2222.2003.
- x.
- Takatory K, Saito A, Yasueda H. The effect of house design and environment on fungal movement in homes of bronchial asthma patients. Mycopathologia. 2000;152:41–49. doi: 10.1023/A:1011933627275.
Supplementary files
