IgE-hypersensitivity to allergens of the fungi Rhizopus Nigricans and Cladosporium Herbarum in childrenwith respiratory allergies

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Abstract


A survey of 111 children diagnosed with respiratory allergies (allergic rhinitis, allergic bronchitis, obstructive bronchitis, recurrent bronchitis, bronchial asthma) aged 1 year to 17 years, of which 58 children have a diagnosis of atopic bronchial asthma of different severity. All children are at risk for the development of fungal sensitization, having a household contact with these allergens. Allergological diagnostics was performed by ELISA using a panel of pediatric and fungal (Rhizopus nigricans and Cladosporium herbarum) biotinylated allergens. As a result of the study revealed that allergens mold Rhizopus nigricans and Cladosporium herbarum are the causal significant factor in the development of respiratory allergies, including asthma, in children at risk. Most often a high level of hypersensivity to Rhizopus nigricans is seen in children aged 2-5 years, Cladosporium herbarum - aged 6-9 years, concomitant to both fungal allergens at the age of 10-17 years. The correlation between the severity of atopic process and degree of sensitization to fungal allergens was not detected. All children with atopic asthma have polyvalent sensitization. Allergens mold Rhizopus nigricans and Cladosporium herbarum must be taken into account in the preparation of a diagnostic panel for children with respiratory allergies at risk. It is necessary to support drug therapy of respiratory allergy in children the activities aimed at elimination of cause significant fungal sensitization everyday surroundings.

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About the authors

Olga P Gurina

St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: ol.gurina@yandex.ru

Russian Federation MD, PhD, Senior Researcher, Research Center

Elena A Dementeva

St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation

Email: zorra2@yandex.ru

Russian Federation Junior researcher, Research Center

Aleksandr E Blinov

St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation

Email: aleks.blinov@mail.ru

Russian Federation Senior Researcher, Research Center

Olga N Varlamova

St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation

Email: ol.varlamova@bk.ru

Russian Federation Senior Researcher, Research Center

Vera I Timokhina

St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation

Email: vera-timokhina@bk.ru

Russian Federation MD, PhD, Senior Researcher, Research Center

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Copyright (c) 2016 Gurina O.P., Dementeva E.A., Blinov A.E., Varlamova O.N., Timokhina V.I.

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