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Structural and functional state of arteries in women with metabolic syndrome associated with autoimmune thyroiditis
- Authors: Kanavets N.S1, Levina L.I1, Vasilenko V.S1, Karpovskaya E.B1, Ribka T.G1, Ivanov S.N1
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Affiliations:
- St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
- Issue: Vol 7, No 4 (2016)
- Pages: 90-95
- Section: Articles
- URL: https://journals.eco-vector.com/pediatr/article/view/5972
- DOI: https://doi.org/10.17816/PED7490-95
- ID: 5972
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Abstract
The aim of the research was to study structural and functional state of arteries in women with metabolic syndrome (MS) associated to autoimmune thyroiditis (AIT), to improve the efficiency of therapeutic and preventive measures. The study sample included 108 women, 40 of them were with metabolic syndrome, autoimmune thyroiditis and euthyroidism (group I), the second group consisted of 31 women with metabolic syndrome, autoimmune thyroiditis and subclinical hypothyroidism (group II) and control group included 37 women with metabolic syndrome without thyroid disease. Laboratory examination included the study of lipid profile ( cholesterol, low-density lipoproteins, LDL Very Low Density Lipoprotein, VLDL, high-density lipoproteins, HDL, triglycerides, atherogenic index), thyroid hormone levels (ATPO and ATG, fТ4, T3) and thyroid stimulating hormone (TSH). Also, patients were instrumental examination with ultrasound of the brachial artery to assess endothelium dependent and endothelium independent relaxation, the definition of complex intima-media thickness. In addition, it performed ultrasound of the kidneys with renal artery duplex scanning with the assessment of renovascular hemodynamics. All patients of the research showed elevated arterial stiffness endothelial dysfunction and remodeling of the vascular wall. These changes are most pronounced in women with metabolic syndrome associated with autoimmune thyroiditis and subclinical hypothyroidism.
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About the authors
Natalia S Kanavets
St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Author for correspondence.
Email: natalia.kanavets@mail.ru
Assistant Professor, Department of Hospital Therapy with Military Therapy and Occupational Medicine Courses Russian Federation
Lilia I Levina
St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: natalia.kanavets@mail.ru
MD, PhD, Dr Med Sci, Professor, Department of Hospital Therapy with Military Therapy and Occupational Medicine Courses Russian Federation
Vladimir S Vasilenko
St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: vasilenkovladi@yandex.ru
MD, PhD, Dr Med Sci, Professor, Head, Department of Hospital Therapy with Military Therapy and Occupational Medicine Courses Russian Federation
Ekaterina B Karpovskaya
St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: karpovskaya@yandex.ru
MD, PhD, Associate Professor, Department of Hospital Therapy with Military Therapy and Occupational Medicine Courses Russian Federation
Tatiana G Ribka
St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: tgrspb@mail.ru
MD, PhD, Associate Professor, Department of Hospital Therapy with Military Therapy and Occupational Medicine Courses Russian Federation
Sergei N Ivanov
St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Email: serg9294723@yandex.ru
MD, PhD, Associate Professor, Department of Hospital Therapy with Military Therapy and Occupational Medicine Courses Russian Federation
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