Contribution of N. P. Kravkov to development of the general, aged, evolutionary and clinical pharmacology (in memoriam to 150 years from the birth)

In the paper, the life and scientific achievements of Nikolai Pavlovich Kravkov (1865-1924), a founder of the Russian pharmacology, head of the Department of Pharmacology, Military Medical Academy, St. Petersburg, were described. N. P. Kravkov carried out significant investigations in pharmacology of gas metabolism, drug toxicology, aged and evolutionary pharmacology, clinical pharmacology (discovery of intravenous and combined narcosis). The main achievement of N. P. Kravkov became the cycle of investigations on isolated organs (ear, heart, lung, spleen, pancreatic gland, thyroid gland, adrenal gland, uterus of the mammalians, head and gills of pike, human fingers, heart and spleen). In these investigations, the rhythmic oscillation of the vascular tonus was proved, the theory of phasic action of pharmacological drugs on tissues, presentations on sensitiveness limits of living protoplasma, possibilities of animation of mummified tissues were postulated. N. P. Kravkov created a large scientific school (S. V. Anichkov, M. I. Gramenitskii, G. L. Shkavera, M. N. Nikolaev, A. I. Kuznetsov, B. S. Sentyurin, V. V. Zakusov, V. A. Valdman). For 25 years (1899-1924) N. P. Kravkov headed the Department of Pharmacology of Military Medical Academy. Commission for awarding the prize V. I. Lenin for scientific work which included the most prominent scientists of our country (O. J. Schmidt was Chairman), A. N. Bach, P. P. Lazarev, S. G. Navashin and M. N. Pokrovsky decided to award the prize to N. P. Kravkov for proceedings in 1926 year.

N. P. Kravkov, pharmacology, isolated organs, phasic action of drugs, intravenous narcosis