电邮这篇文章 急性淋巴细胞白血病儿童化疗所致多发性神经病变的临床和神经肌电图征象的研究
- 作者: Koryakina O.V.1, Kovtun O.P.1, Sabitov A.U.1, Pediatric L.G.2, Mikhailovskya S.I.2, Repakova A.V.1
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隶属关系:
- Ural State Medical University
- Regional Children Clinical Hospital
- 期: 卷 12, 编号 3 (2021)
- 页面: 15-23
- 栏目: Original studies
- URL: https://journals.eco-vector.com/pediatr/article/view/83048
- DOI: https://doi.org/10.17816/PED12315-23
- ID: 83048
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详细
绪论在血液学中，迫切需要解决的问题之一是成血细胞增多。现代治疗方法已明显改善了成血细胞增多症的预后。然而，化疗的使用伴随着高频率的药物并发症，包括那些与神经毒性有关的。在疾病的主要临床症状之外加上神经系统症状会显著加重患者病情的严重程度，影响预后和生活质量。本文介绍急性淋巴细胞白血病患儿化疗引起的多神经病变的神经生理学特点。
本研究的目的是比较急性淋巴细胞白血病患儿化疗引起的多神经病变的临床表现和神经生理征象。
材料与方法。以The Regional Children's Clinical Hospital of Yekaterinburg在2019–2020年为基础， 对21例年龄为3至17岁儿童的临床图像进行分析并评价神经电图（ENMG）研究。
结果。在儿童研究组中，根据神经生理学研究，几乎所有患者（95.2%）在诱导化疗阶段就确定了周围性多神经病变的体征。腓骨神经运动轴突神经病的优势被揭示。同时，25%的患者记录了临床表现。在4个月的动态随访中，所有有周围神经损伤神经生理体征的儿童都出现了相应的神经症状。根据ENMG的研究结果，出现了消极的趋势。混合型多神经病变患者增加了1.7倍。在每三分之一的儿童中，M波的振幅和冲动传导速度的速率都有所下降。
结论。所获得的数据决定了需要尽早采用神经生理学方法进行研究，以确定急性淋巴细胞白血病患儿接受化疗时神经毒性并发症形成的高危人群，并及时预约一套复杂的治疗措施。
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作者简介
Oksana Koryakina
Ural State Medical University
编辑信件的主要联系方式.
Email: koryakina09@mail.ru
MD, PhD, Associate Professor, Department of Nervous Diseases, Neurosurgery and Medical Genetics
俄罗斯联邦, EkaterinburgOlga Kovtun
Ural State Medical University
Email: usma@usma.ru
MD, PhD, Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences,Rector, Department of Polyclinic Pediatrics and Pediatrics, Faculty of Advanced Studies and Professional Retraining
俄罗斯联邦, EkaterinburgAlebai Sabitov
Ural State Medical University
Email: postdiplom@usma.ru
MD, PhD, Dr. Sci. (Med.), Professor, Head of the Department of Infectious Diseases and Clinical Immunology, Prorector. Department of Infectious Diseases and Clinical Immunology
俄罗斯联邦, EkaterinburgLarisa Pediatric
Regional Children Clinical Hospital
Email: fechinalg@mis66.ru
MD, PhD, Deputy Chief Physician forOncology and Hematology. Center for Pediatric Oncology and Hematology
俄罗斯联邦, EkaterinburgSvetlana Mikhailovskya
Regional Children Clinical Hospital
Email: tuss166@yandex.ru
Head of the Department of Functional Diagnostics
俄罗斯联邦, EkaterinburgAnna Repakova
Ural State Medical University
Email: koryakina09@mail.ru
functional diagnostics doctor, Department of Functional Diagnostics
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