利用他生的间充质干细胞和基于脂肪族共聚酰胺的伤口敷料在微自体皮肤成形中的可能性

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论证：创伤缺损患者的治疗是临床医学中急需解决的问题，以外科医生和创伤科医生为主的各专业医生都面临着这个问题。不管创伤的病因是什么，创伤过程总是服从基本的病理生理模式。尽管在伤口局部治疗（细胞技术、现代创面覆盖物等）方面取得了医学科学的成就，但手术方法仍然是主要
方法。修复再生优化技术的研究仍在继续，这表明目前还没有一种通用的修复再生算法。这在向有大量层错的受害者提供援助时特别重要，这些缺陷往往导致捐助资源短缺。

目的是通过使用异体间充质干细胞和基于脂肪族共聚物的伤口敷料来提高微自体真皮成形术
的效率。

材料与方法。本文介绍了一项涉及50只小实验动物（大鼠）的实验研究结果。根据局部治疗的方法将所有动物分成不同的组，实验创面按照其自身独创的技术建模。采用测面积法和组织学研究方法以及计算愈合指数来评估分析方法的有效性。

结果。治疗实验性创面最有效的方法是用基于脂肪族共聚酰胺和成脂间充质干细胞的创面敷料进行微真皮成形术。发现治疗后28天的微真皮成形术结合一个基于脂肪族共聚酰胺涂层和脂肪形成的间充质干细胞，缺陷区域与控制相比，降低了16倍和治疗指数最高的所有方法—12.5单位。高再生电位也被组织学检查的结果证实。最差的结果是只使用脂肪源性间充质干细胞进行微真皮成形术而不使用皮肤或创面敷料覆盖伤口的组。

结论。将所分析的方法在临床实践中介绍，将提高不同病因的创面缺损患者的治疗效果。

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作者简介

Vasily Gordienko

Saint Petersburg State Pediatric Medical University

Email: chet1337@gmail.com
ORCID iD: 0000-0003-0590-2137
SPIN 代码: 4069-2346

MD, assistant at the Laboratory of Experimental Surgery

俄罗斯联邦, 2, Litovskay street, Saint-Peterburg, 194100

Evgenii Zinoviev

Saint Petersburg State Pediatric Medical University; Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine

Email: evz@list.ru
ORCID iD: 0000-0002-2493-5498
SPIN 代码: 4069-2346

MD, PhD, D.Sc., Professor, Head of the Department of Thermal Injuries Unit; Head of the Laboratory of Experimental Surgery

俄罗斯联邦, 2, Litovskay street, Saint-Peterburg, 194100; 3, Budapeshtskaya street, Saint-Petersburg, 192242

Denis Kostyakov

Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine

编辑信件的主要联系方式.
Email: kosdv@list.ru
ORCID iD: 0000-0001-5687-7168
SPIN 代码: 9966-5821

MD, PhD, researcher of the Department of Thermal Injuries Unit

俄罗斯联邦, 3, Budapeshtskaya street, Saint-Petersburg, 192242

Marat Asadulaev

H. Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery

Email: marat.asadulaev@yandex.ru
ORCID iD: 0000-0002-1768-2402
SPIN 代码: 3336-8996
Scopus 作者 ID: 57191618743

MD, clinical resident, laboratory assistant in the Laboratory of Experimental Surgery

俄罗斯联邦, 64, Parkovaya str., Saint-Petersburg, Pushkin, 196603

Anton Shabunin

H. Turner National Medical Research Center for Сhildren’s Orthopedics and Trauma Surgery; Peter the Great Saint Petersburg Polytechnic University

Email: anton-shab@yandex.ru
ORCID iD: 0000-0002-8883-0580
SPIN 代码: 1260-5644
Scopus 作者 ID: 57191623923

laboratory assistant in the Laboratory of Experimental Surgery; PhD student

俄罗斯联邦, 64, Parkovaya str., Saint-Petersburg, Pushkin, 196603; 29, Polytechnitcheskaya street, St.-Petersburg, 195251

Vladimir Yudin

Peter the Great Saint Petersburg Polytechnic University

Email: yudin@hq.macro.ru
ORCID iD: 0000-0002-5517-4767
SPIN 代码: 4996-7540
Scopus 作者 ID: 7103377720

Dr. Phys.-Math. Sci., Professor, Director of Laboratory of Polymeric Materials for Tissue Engeneering and Transplantology

俄罗斯联邦, 29, Polytechnitcheskaya street, St.-Petersburg, 195251

Nataliya Smirnova

Peter the Great Saint Petersburg Polytechnic University; Institute of Macromolecular Compounds of the Russian Academy of Sciences

Email: nvsmirnoff@yandex.ru

PhD, Senior Researcher of Laboratory of Polymer Materials for Tissue Engineering and Transplantology; researcher in Laboratory of Mechanics of Polymers and Composite Materials

俄罗斯联邦, 29, Polytechnitcheskaya street, St.-Petersburg, 195251; 31, Bolshoy prospect, St-Petersburg 199004

Anna Radeeva

Saint Petersburg State Pediatric Medical University

Email: anyawinteranya@gmail.com
ORCID iD: 0000-0002-6152-4276

student

俄罗斯联邦, 2, Litovskay street, Saint-Peterburg, 194100

Moisei Paneiakh

Saint Petersburg State Pediatric Medical University

Email: moisey031190@gmail.com
ORCID iD: 0000-0002-2527-9058

Assistant Professor, Department of Pathological Anatomy at the Rate of Forensic Medicine

俄罗斯联邦, 2, Litovskay street, Saint-Peterburg, 194100

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版权所有 © Gordienko V., Zinoviev E., Kostyakov D., Asadulaev M., Shabunin A., Yudin V., Smirnova N., Radeeva A., Paneiakh M., 2020

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