Email this article 
Prevalence and predictors of incidence of urolithiasis in a representative region
- Authors: Streltsova O.S.1, Krupin V.N.1, Lazukin V.F.1, Pochtin D.P.2, Khalili V.D.1, Manakova E.A.3
-
Affiliations:
- Privolzhskii Research Medical University
- N.A. Semashko Nizhny Novgorod Regional Clinical Hospital
- LLC “Centralized Laboratory AVK-Med”
- Issue: Vol 12, No 2 (2022)
- Pages: 105-116
- Section: Original articles
- URL: https://journals.eco-vector.com/uroved/article/view/105423
- DOI: https://doi.org/10.17816/uroved105423
- ID: 105423
Cite item
Open Access
Access granted
Abstract
BACKGROUND: Domestic and foreign studies have shown the presence of correlations between the prevalence of urolithiasis, anthropogenic factors, and composition of the water consumed by the population. In the Nizhny Novgorod Region, there is a high incidence of urolithiasis; thus, the identification of its causes appears to be an urgent task.
AIM: To assess the prevalence and identify predictors of the incidence of urolithiasis in the rural population of the Nizhny Novgorod Region.
MATERIALS AND METHODS: The study was conducted in the Nizhny Novgorod Region. Annual reports of patients seeking medical care for urolithiasis for 3 years in 49 central district hospitals and two large regional hospitals were analyzed. The incidence rate of urolithiasis was calculated according to the treatment of patients with urolithiasis also for 3 years in relation to the population of each district. Information about drinking sources was obtained by questioning 800 patients with urolithiasis who were treated at the Nizhny Novgorod Regional Clinical Hospital. The chemical composition of drinking water was assessed in accordance with the requirements for drinking water SanPiN 2.1.4.1074-01. The mineralogical composition of 1000 urinary stones of patients from rural areas of the Nizhny Novgorod Rregion was retrospectively analyzed using a Nicolet iS5 IR-Fourier spectrometer.
RESULTS: In this study, 38 (77.5%) districts of the Nizhny Novgorod Region have unfavorable conditions for urolithiasis. Moreover, 59.5% of the rural population are using water from underground sources (wells). Significant correlations were found between the incidence of urolithiasis and the chemical composition of the water consumed, particularly water hardness. The analysis of the mineralogical composition of urinary stones showed their polycomponent composition in 89.5% of the cases. Differences in the chemical composition of stones are associated with the environmental factors of the region, one of which is drinking water.
CONCLUSIONS: Most of the rural population of the Nizhny Novgorod Region is at risk for urolithiasis. Significant differences in the incidence of urolithiasis were dependent on the degree of hardness of the groundwater used for drinking. Increased water hardness is a significant risk factor for the development of urolithiasis.
Full Text
About the authors
Olga S. Streltsova
Privolzhskii Research Medical University
Author for correspondence.
Email: strelzova_uro@mail.ru
ORCID iD: 0000-0002-9097-0267
SPIN-code: 9674-0382
Dr. Sci. (Med.), Professor of the E.V. Shakhov Department of Urology
Russian Federation, Nizhny NovgorodValentin N. Krupin
Privolzhskii Research Medical University
Email: vn.krupin@mail.ru
ORCID iD: 0000-0002-4887-4888
SPIN-code: 8892-7661
Scopus Author ID: 7003284228
Dr. Sci. (Med.), Professor, Head of the E.V. Shakhov Department of Urology
Russian Federation, Nizhny NovgorodValery F. Lazukin
Privolzhskii Research Medical University
Email: valery-laz@yandex.ru
ORCID iD: 0000-0003-0916-0468
SPIN-code: 3400-9905
Cand. Sci. (Biol.), Associate Professor of the Department of Medical Physics and Informatics
Russian Federation, Nizhny NovgorodDmitry P. Pochtin
N.A. Semashko Nizhny Novgorod Regional Clinical Hospital
Email: dpochtin@mail.ru
Urologist
Russian Federation, Nizhny NovgorodVasif D. Khalili
Privolzhskii Research Medical University
Email: khalili.vasif@yandex.ru
ORCID iD: 0000-0002-2793-4407
Clinical Resident of the E.V. Shakhov Department of Urology
Russian Federation, Nizhny NovgorodElvira A. Manakova
LLC “Centralized Laboratory AVK-Med”
Email: e.manakova@gemohelp.ru
Director for Medicine, LLC “Centralized Laboratory AVK-Med”
Russian Federation, Nizhny NovgorodReferences
- Turney BW, Reynard JM, Noble JG, Keoghane SR. Trends in urological stone disease. BJU Int. 2012;109(7):1082–1087. doi: 10.1111/j.1464-410X.2011.10495.x
- Apolihin OI, Sivkov AV, Komarova VA, et al. Urolithiasis in the Russian Federation (2005–2016). Experimental and clinical urology. 2018;(4):4–14. (In Russ.)
- Skolarikos A, Neisius A, Petřík A, et al. EAU Guidelines on Urolithiasis. European Association of Urology, 2021. 114 p. URL: https://uroweb.org/guidelines/urolithiasis
- Aleksandrov GA, Polikarpov AV, Golubev NA, et al editors. Zabolevaemost’ vsego naseleniya Rossii v 2016. Statisticheskie materialy. Chast’ I [Internet]. Moscow, 2017. 140 p [cited 2022 Jan 01]. Available from: https://www.rosminzdrav.ru/ministry/61/22/stranitsa-979/statisticheskie-i-informatsionnye-materialy/statisticheskiy-sbornik-2016-god (In Russ.)
- Kaprin AD, Apolihin OI, Sivkov AV, et al. The analysis of uronephrologic morbidity and mortality in Russian Federation during the period of 2002–2014 according to the official statistics. Experimental and clinical urology. 2016;(3):4–13. (In Russ.)
- Heers H, Turney BW. Trends in urological stone disease: A 5-year update of hospital episode statistics. BJU International. 2016;118(5):785–789. doi: 10.1111/bju.13520
- Malhasyan VA, Ivanov VYu, Hodyreva LA, et al. Analysis of specialized medical care to patients with renal colic in Moscow urological hospitals. Experimental and clinical urology. 2016;(4):18–25. (In Russ.)
- Aleksandrova GA, Golubev NA, Tyurina EM, et al. Zabolevaemost’ vsego naseleniya Rossii v 2019 godu s diagnozom, ustanovlennym vpervye v zhizni: statisticheskie materialy. Moscow: Departament monitoringa, analiza, i strategicheskogo razvitiya zdravookhraneniya Minzdrav Rossii, FGBU “TSNIIOIZ” Minzdrava Rossii, 2020. 140 p. (In Russ.)
- Guo Z-L, Wang J-Y, Gong L-L, et al. Association between cadmium exposure and urolithiasis risk: A systematic review and meta-analysis. Medicine. 2018;97(1):e9460. doi: 10.1097/MD.0000000000009460
- Medvedev EV. Relationship between microelements content of drinkable water and nephro-lithiasis formation in Moscow region residents. Russian Journal of Occupational Health and Industrial Ecology. 2007;(2):14–17. (In Russ.)
- Sulaiman SK, Enakshee J, Traxer O, Somani BK. Which Type of Water Is Recommended for Patients with Stone Disease (Hard or Soft Water, Tap or Bottled Water): Evidence from a Systematic Review over the Last 3 Decades. Curr Urol Rep. 2020;21:6. doi: 10.1007/s11934-020-0968-3
- Territorial’nyi organ Federal’noi sluzhby gosudarstvennoi statistiki po Nizhegorodskoi oblasti [Internet]. Ofitsial’naya statistika PFO [cited 2022 Jan 30]. Available from: https://nizhstat.gks.ru/ folder/38723 (In Russ.)
- Federal’naya sluzhba gosudarstvennoi statistiki [Internet]. Chislennost’ postoyannogo naseleniya Rossii na 1 yanvarya [cited 2022 Jan 30]. Available from: https://rosstat.gov.ru (In Russ.)
- Okladnikova SM, Aleksandrova OA, Bugakova NS, et al editors. Regiony Rossii. Sotsial’no-ehkonomicheskie pokazateli. 2020: R32 Stat. sb. Moscow: Rosstat, 2020. 1242 p. (In Russ.)
- Kratkaya informatsiya o sostoyanii podzemnykh vod v raione g. Nizhnego Novgoroda [Internet]. [cited 2022 Jan 30]. Available from: http://geomonitoring.ru/download/spravki/pfo/Справка%20Нижегородская%20область.pdf (In Russ.)
- Federal’naya sluzhba po nadzoru v sfere zashchity prav potrebitelei i blagopoluchiya cheloveka. O sostoyanii sanitarno-ehpidemiologicheskogo blagopoluchiya naseleniya v Rossiiskoi Federatsii v 2019 godu: Gosudarstvennyi doklad. Moscow: Federal’naya sluzhba po nadzoru v sfere zashchity prav potrebitelei i blagopoluchiya cheloveka, 2020. 299 p. (In Russ.)
- Kustov AV, Strel’nikov AI, Smirnov PR, et al. Quantitative mineralogical analysis and structure of urinary stones in patients living in Ivanovo region. Urologiia. 2016;(3):19–25. (In Russ.)
- Strohmaier WL, Seilnacht J, Schubert G. Clinical significance of uric acid dihydrate in urinary stones. Urol Res. 2011;39:357–360. doi: 10.1007/s00240-010-0356-4
- Schubert G. Urinary stone analysis. In: Rao PN, Preminger GN, Kavanagh JP, editors. Urinary tract stone disease. London: Springer-Verlag, 2011. P. 341–353. doi: 10.1007/978-1-84800-362-0_29
- Spravochnik MSD. Professional’naya versiya [Internet]. [cited 2021 Dec 28]. Available from: https://www.msdmanuals.com/ru/профессиональный/патология-мочеполовой-системы/мочевые-конкременты/мочевые-конкременты. (In Russ.)
- Curham G. Epidemiology. In: Rao PN, Preminger GN, Kavanagh JP, editors. Urinary tract stone disease. London: Springer-Verlag, 2011. P. 3–9. doi: 10.1007/978-1-84800-362-0_1
- Rodgers A, Trinchieri A, Ather MH, et al. Vision for the future on urolithiasis: research, management, education and training-some personal views. Urolithiasis. 2019;47:401–413. doi: 10.1007/s00240-018-1086-2
Supplementary files
