Selective serotonin reuptake inhibitor and fertility potential of the men. Psychiatry and Urology. At the junction of related disciplines

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  • 作者: Korshunov M.N.1,2, Korshunova E.S.3,4
  • 隶属关系:
    1. Central State Medical Academy
    2. Russian-German Centre of Reproduction and Clinical Embriology
    3. National Medical Research Radiological Center
    4. Research Institute of Health Organization and Health Management
  • 期: 卷 6, 编号 3 (2016)
  • 页面: 19-25
  • 栏目: Articles
  • ##submission.dateSubmitted##: 14.12.2016
  • ##submission.datePublished##: 15.09.2016
  • URL: https://journals.eco-vector.com/uroved/article/view/5861
  • DOI: https://doi.org/10.17816/uroved6319-25
  • ID: 5861
  • ##submission.retractionDate##: 19.06.2024
  • ##submission.retractionreason##:

    At the suggestion of Eco-Vector Publishing House and in accordance with the recommendations of the Association of Science Editors and Publishers (ASEP), the editorial board of the journal conducted a comparative analysis of two articles [“Selective serotonin reuptake inhibitor and fertility potential of the men. Psychiatry and Urology. At the junction of related disciplines” (authors, Korshunov MN, Korshunova ES) // Urologicheskie Vedomosti. 2016;6(3):19–25. EDN: XBHVED doi: 10.17816/uroved6319-25 (submitted 22.06.2016, approved 19.08.2016) and “Influence of the selective serotonin re-uptake inhibitors on spermatogenesis” (authors, Korshunov MN, Korshunova ES, Shtyrya YuA, Vinogradov IV) // Experimental and Clinical Urology. 2015;(4);67–70. EDN: VPNHLR], which showed almost complete coincidence of the texts of these publications. The sections “Materials and Methods”, “Results”, “Discussion”, “Conclusions”, and bibliography are completely identical; the “Introduction” sections differ by one paragraph. The article “Selective serotonin reuptake inhibitor and fertility potential of the men. Psychiatry and Urology. At the junction of related disciplines”, published in the journal Urologicheskie Vedomosti, is a semantic copy of the article “Influence of the selective serotonin re-uptake inhibitors on spermatogenesis”, published in the journal Experimental and Clinical Urology. It is noted that the date of receipt of the manuscript by the journal Urologicheskie Vedomosti is later than the date of receipt of an identical manuscript by the journal Experimental and Clinical Urology. Due to the identification of duplication of articles in two scientific journals, on June 19, 2024, the Editorial Board of the journal Urologicheskie Vedomosti decided to retract the article “Selective serotonin reuptake inhibitor and fertility potential of the men. Psychiatry and Urology. At the junction of related disciplines” (authors, Korshunov MN, Korshunova ES) // Urologicheskie Vedomosti. 2016;6(3):19–25. EDN: XBHVED doi: 10.17816/uroved6319-25 (submitted 22.06.2016, approved 19.08.2016).



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https://journals.eco-vector.com/uroved/article/view/634866


Introduction. Iinfertility leads to emotional stress, which is a precipitating factor of depression. Stress has also been recognized as one of possible reasons of pathospermia and infertility. The aim of pilot study: to evaluate SSRIs effects on spermatogenesis and fertility in the treatment of depression. 

Material and Methods. Study included 19 fertile men with depression of mild severity. None of them had any urological disorders. They were treated by fluoxetine 20 mg per day during 6 weeks. Semen analysis (WHO 5), level of DNA fragmentation were performed before, after the therapy and 3 months of drug discontinuation. 

Results. All the men had normal semen parameters and level of DNA fragmentation before the treatment. After 6 weeks of the treatment, we fixed the reduction of sperm´s parameters and increasing the level of DNA fragmentation. After 3 mounts of drug discontinuation the mean semen volume, sperm concentration, motility, percentage of normal morphology increased and reverted to the normal levels. Sperm DNA fragmentation index decreased and it had the values less then before the treatment that positive correlated with the reduction of depression’s symptoms. 

Conclusions. Using SSRIs may have a negative effect on spermatogenesis and male fertility within the therapy. The most changes of sperm quality (morphology and DNA integrity) were registered. 3 months of drug discontinuation the semen parameters reverted to the normal levels. The infuence of SSRIs in infertile men with depression are to be studied in more detail.

作者简介

Maksim Korshunov

Central State Medical Academy;
Russian-German Centre of Reproduction and Clinical Embriology

编辑信件的主要联系方式.
Email: m_korshunov@bk.ru
MD, PhD, associate professor, Department of Urology 俄罗斯联邦

Ekaterina Korshunova

National Medical Research Radiological Center;
Research Institute of Health Organization and Health Management

Email: e_korshunova@mail.ru
MD, PhD, senior research fellow 俄罗斯联邦

参考

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