Ejaculate parameters and the results of in vitro fertilization treatment in infertile couples with overweight and obese men

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Abstract

BACKGROUND: Infertility and obesity are actual and at the same time occurring problems of many couples. Conflicting data have been obtained on ejaculate parameters and the results of infertility treatment using in vitro fertilization treatment (IVF) in overweight and obese men.

AIM: To evaluate the results of examination and treatment using ART, depending on the body mass index (BMI) of men in infertile couples.

MATERIALS AND METHODS: A retrospective analysis of the results of treatment at the International Center for Reproductive Medicine in 368 infertile couples was carried out. The mean age of men and women was 36.4 ± 6.2 and 33.9 ± 5 years, respectively. Previous treatment for varicocele, sexually transmitted infections, prostatitis and cryptorchidism was performed in 58 (15.7%), 43 (11.7%), 42 (11.4%) and 11 (2.9%) men, respectively. Height and weight were measured for all patients, and BMI was calculated. The ejaculate was processed using a gradient medium (SupraSperm, Origio), IVF or ICSI were used in 110 (29.9%) and 258 (70.1%) couples, respectively, signs of good embryo quality were determined according to recommendations of professional societies for reproductive medicine. The onset of pregnancy was confirmed by the results of ultrasound sonography of the uterus. The results were subjected to statistical analysis.

RESULTS: The BMI mean was 27.4 ± 4.4 kg/m2, overweight and obesity of the 1st and 2nd degrees were observed in 161 (43%), 58 (15.8%) and 23 (7%) men respectively. Higher BMI values of men corresponded to higher BMI values of women (p < 0.001), BMI values did not depend on ejaculate volume, concentration, total number and number of motile spermatozoa, proportion of high-quality embryos, and pregnancy rate. The highest pregnancy rate was noted after treatment of couples with younger women and higher values of the total number, concentration and number of progressively motile spermatozoa and ejaculate volume (p = 0.037, p = 0.028, p < 0.001, p = 0.003, p < 0.0001, respectively).

CONCLUSIONS: Overweight and obese men prevail in infertile couples seeking IVF treatment. IVF treatment can overcome infertility in couples with overweight and obese men.

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About the authors

Igor A. Korneyev

Pavlov First Saint Petersburg State Medical University; International Centre for Reproductive Medicine

Author for correspondence.
Email: iakorneyev@yandex.ru
ORCID iD: 0000-0001-7347-1901
SPIN-code: 4780-2266
Scopus Author ID: 6506000592
ResearcherId: R-3046-2017
https://professiya-vrach.ru/heroes/sankt-peterburg/korneev-igor-alekseevich/

Dr. Sci. (Med.), Professor of the Department of Urology

Russian Federation, 6-8, L’va Tolstogo st., Saint Petersburg, 197022; Saint Petersburg

References

  1. Agarwal A, Mulgund A, Hamada A, Chyatte MR. A unique view on male infertility around the globe. Reprod Biol Endocrinol. 2015;13:37. doi: 10.1186/s12958-015-0032-1
  2. Levine H, Jorgensen N, Martino-Andrade A, et al. Temporal trends in sperm count: a systematic review and meta-regression analysis. Hum Reprod Update. 2017;1;23(6):646–659. doi: 10.1093/humupd/dmx022
  3. Ng M, Fleming T, Robinson M, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384(9945):766–781. doi: 10.1016/S0140-6736(14)60460-8
  4. Ramlau-Hansen CH, Thulstrup AM, Nohr EA, et al. Subfecundity in overweight and obese couples. Hum Reprod. 2007;22(6): 1634–1637. doi: 10.1093/humrep/dem035
  5. Pinborg A, Gaarslev C, Hougaard CO, et al. Influence of female bodyweight on IVF outcome: a longitudinal multicentre cohort study of 487 infertile couples. Reprod Biomed Online. 2011;23(4):490–499. doi: 10.1016/j.rbmo.2011.06.010
  6. Epanchintseva EA, Selyatitskaya VG, Sviridova MA. Lutov YuV. Sociomedical risk factors for male infecundity. Andrology and genital surgery. 2016;17(3):47–53. (In Russ.) doi: 10.17650/2070-9781-2016-17-3-47-53
  7. Sundaram R, Mumford SL, Buck Louis GM. Couple’s body composition and time-to-pregnancy. Hum Reprod. 2017;32(3):662–668. doi: 10.1093/humrep/dex001
  8. Kolotkin RL, Binks M, Crosby RD, et al. Obesity and sexual quality of life. Obesity (Silver Spring). 2006;14(3):472–479. doi: 10.1038/oby.2006.62
  9. Burn H, Gunn S, Chowdhry S, et al. Comprehensive Review and Case Study on the Management of Buried Penis Syndrome and Related Panniculectomy. Eplasty. 2018;18: e5.
  10. Nimbi FM, Virginia C, Cinzia DM, et al. The relation between sexuality and obesity: the role of psychological factors in a sample of obese men undergoing bariatric surgery. Int J Impot Res. 2020; doi: 10.1038/s41443-020-00388-2
  11. Durairajanayagam D, Agarwal A. Causes, effects and molecular mechanisms of testicular heat stress. Reprod Biomed Online. 2015;30(1):14–27. doi: 10.1016/j.rbmo.2014.09.018
  12. Sepidarkish M, Maleki-Hajiagha A, Maroufizadeh S, et al. The effect of body mass index on sperm DNA fragmentation: a systematic review and meta-analysis. Int J Obes. 2020; 44(3):549–558. doi: 10.1038/s41366-020-0524-8
  13. Agarwal A, Parekh N, Panner Selvam MK, et al. Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility. World J Mens Health. 2019;37(3):296–312. doi: 10.5534/wjmh.190055
  14. Saez Lancellotti TE, Boarelli PV, Monclus MA, et al. Hypercholesterolemia impaired sperm functionality in rabbits. PLoS One. 2010;5(10): e13457. doi: 10.1371/journal.pone.0013457
  15. Best D, Avenell A, Bhattacharya S. How effective are weight-loss interventions for improving fertility in women and men who are overweight and obese? A systematic review and meta-analysis of the evidence. Hum Reprod Update. 2017;23(6):681–705. doi: 10.1093/humupd/dmx027
  16. Eniarsson S, Bergh C, Friberg B, et al. Weight reduction intervention for obese infertile women prior to IVF: a randomized control trial. Hum Reprod. 2017;32(8):1621–1630. doi: 10.1093/humrep/dex235
  17. Snoek KM, Steegers-Theunissen RPM, et al. The effects of bariatric surgery on periconception maternal health: a systemic review and meta-analysis. Hum Reprod Update. 2021;27(6):1030–1055. doi: 10.1093/humupd/dmab022
  18. Wood GJA, Tiseo DC, Paluello DV, et al. Bariatric surgery impact on reproductive hormones, semen analysis, and sperm DNA fragmentation in men with severe obesity: prospective study. Obes Surg. 2020;30:4840–4851. doi: 10.1007/s11695-020-04851-3
  19. Ribas-Maynou J, Yeste M, Becerra-Tomás N, et al. Clinical implications of sperm DNA damage in IVF and ICSI: updated systematic review and meta-analysis. Biol Rev Camb Philos Soc. 2021;96(4):1284–1300. doi: 10.1111/brv.12700
  20. Campbell JM, Lane M, Owens JA, Bakos HW. Paternal obesity negatively affects male fertility and assisted reproduction outcomes: a systematic review and meta-analysis. Reprod Biomed Online. 2015;31(5):593–604. doi: 10.1016/j.rbmo.2015.07.012
  21. Mushtaq R, Pundir J, Achilli C, et al. Effect of male body mass index on assisted reproduction treatment outcome: an updatedsystematic review and meta-analysis. Reprod Biomed Online. 2018;36(4):459–471. doi: 10.1016/j.rbmo.2018.01.002
  22. Silventoinen K, Kaprio J, Lahelma E, et al. Assortive mating by body height and BMI. Finnish twins and their spouses. Am J Hum Biol. 2003;15(5):620–627. doi: 10.1002/ajhb.10183
  23. World Health Organization. WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction, 5th ed. Cambridge: Cambridge University Press; 2010. 77 p. Available from: https://apps.who.int/iris/handle/10665/44261
  24. A guide to assisted reproductive technology for doctors and embryologists. Korsak VS, ed. Moscow. SIMK; 2015. 232 p. (In Russ.)
  25. Gardner DK, Schoolcraft WB. Culture and transfer of human blastocysts. Curr Opin Obstet Gynecol. 1999;11(3):307–311. doi: 10.1097/00001703-199906000-00013
  26. Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology. The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum Reprod. 2011;26(6):1270–1283. doi: 10.1093/humrep/der037
  27. Ng M, Fleming T, Robinson M, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384(9945):766–781. doi: 10.1016/S0140-6736(14)60460-8
  28. Muromtseva GA, Kontsevaya AV, Konstantinov VV, et al. The prevalence of non-infectious diseases risk factors in Russian population in 2012–2013 years. The results of ECVD-RF. Cardiovascular Therapy and Prevention. 2014;13(6):4–11. (In Russ.) doi: 10.15829/1728-8800-2014-6-4-11
  29. Balanova YuA, Shalnova SA, Deev AD, et al. Obesity in Russian population — prevalence and association with non-communicable diseases risk factors. Russ J Cardiol. 2018;23(6):123–130. (In Russ.) doi: 10.15829/1560-4071-2018-6-123-130
  30. MacDonald AA, Herbison GP, Showell M, Farquhar CM. The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis. Hum Reprod Update. 2010;16(3):293–311. doi: 10.1093/humupd/dmp047

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