Effectiveness of melatonin use in treatment of premature ejaculation combined with erectile dysfunction

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Abstract

The article presents the results of the treatment of 60 patients with premature ejaculation in combination with erectile dysfunction. Patients were divided into three groups, in which patients were prescribed non-drug treatment, or sildenafil 50 mg on demand, or sildenafil 50 mg on demand in combination with melatonin 3 mg at night. Duration of treatment was 6 months. The psychoemotional status, quality of life, quality and duration of intercourse, erectile function and chrono-rhythms of patients were assessed. The results of the study showed that treatment with sildenafil in combination with melatonin was the most clinically effective, which manifested in prolongation of sexual intercourse, improvement of the quality of erection and normalization of the chronobiological status of patients.

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About the authors

Andrey V. Kuzmenko

N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: kuzmenkoav09@yandex.ru
http://vrngmu.ru/academy/personnel/978/

Doctor of Medical Science, Professor, Head of the Department

Russian Federation, Voronezh

Timur A. Gyaurgiev

N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of the Russian Federation

Email: tima001100@mail.ru

Candidate of Medical Science, Associate Professor of the Urology Department

Russian Federation, Voronezh

Artem A. Vishnyakov

N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of the Russian Federation

Email: bars0505@mail.ru

Consultant

Russian Federation, Voronezh

Daler V. Tizyo

N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of the Russian Federation

Email: tyzo.daler@mail.ru

Student

Russian Federation, Voronezh

References

  1. Althof SE, McMahon CG, Waldinger MD, et al. An Update of the International Society of Sexual Medicine’s Guidelines for the Diagnosis and Treatment of Premature Ejaculation (PE). Sex Med. 2014;2(2):60-90. https://doi.org/10.1002/sm2.28.
  2. Ахвледиани Н.Д. Лечение вторичного преждевременного семяизвержения, связанного с эректильной дисфункцией // Медицинский совет. – 2016. – № 5. – С. 94–97. [Akhvlediani ND. Lechenie vtorichnogo prezhdevremennogo semyaizverzheniya, svyazannogo s erektil’noy disfunktsiey. Meditsinskiy sovet. 2016;(5):94-97. (In Russ.)]
  3. Chen X, Wang FX, Hu C, et al. Penile sensory thresholds in subtypes of premature ejaculation: implications of comorbid erectile dysfunction. Asian J Androl. 2018;20(4):330-335. https://doi.org/10.4103/aja.aja_62_17.
  4. Yang X, Gao M, Zhang L, et al. Central Neural Correlates During Inhibitory Control in Lifelong Premature Ejaculation Patients. Front Hum Neurosci. 2018;12:206. https://doi.org/10.3389/fnhum.2018.00206.
  5. Яровой C.К., Хромов Р.А., Джалилов О.В. Современные тенденции в лечении преждевременной эякуляции // Эффективная фармакотерапия. – 2018. – № 29. – С. 26–33. [Yarovoy CK, Khromov RA, Dzhalilov OV. Current trends in premature ejaculation treatment. Effektivnaya farmakoterapiya. 2018;(29):26-33. (In Russ.)]
  6. Donatucci CF. Etiology of ejaculation and pathophysiology of premature ejaculation. J Sex Med. 2006;3 Suppl 4:303-308. https://doi.org/10.1111/j.1743-6109.2006.00305.x.
  7. Ахвледиани Н.Д., Матюхов И.П. Доказательность эффективности и безопасности дапоксетина при лечении преждевременного семяизвержения // Урология. – 2017. – № 5. – С. 106–110. [Akhvlediani ND, Matyukhov IP. The evidence for the efficiency and safety of dapoxetine in treating premature ejaculation. Urologiia. 2017;(5):106-110. (In Russ.)]. https://doi.org/10.18565/urology.2017.5.106-110.
  8. Демидко Ю.Л., Григорян В.А., Крупинов Г.Е., и др. Методы лечения преждевременной эякуляции // РМЖ. Медицинское обозрение. – 2018. – Т. 2. – № 2–1. – С. 23–25. [Demidko YuL, Grigoryan VA, Krupinov GE, et al. Metody lecheniya prezhdevremennoy eyakulyatsii. RMZh. Meditsinskoe obozrenie. 2018; (22-1):23-25. (In Russ.)]
  9. Screponi E, Carosa E, Di Stasi SM, et al. Prevalence of chronic prostatitis in men with premature ejaculation. Urology. 2001;58(2): 198-202. https://doi.org/10.1016/s0090-4295(01)01151-7.
  10. Гамидов С.И., Щербаков Д.В., Тажетдинов О.Х., и др. Эффективность применения тадалафила у больных с преждевременной эякуляцией в сочетании с эректильной дисфункцией // Вестник РГМУ. – 2010. – № 6. – С. 54–58. [Gamidov SI, Shcherbakov DV, Tazhetdinov OKh, et al. Efficacy of tadalafil in patients with premature ejaculation, combined with erectile dysfunction. Bulletin of RSMU. 2010;(6):54-58. (In Russ.)]
  11. Шелковникова Т.В., Догадин С.А. Современные представления о взаимосвязи гормонов щитовидной железы и гонад у мужчин // Сибирское медицинское обозрение. – 2013. – № 1. – С. 9–14. [Shelkovnikova TV, Dogadin SA. Modern views on the relationship of thyroid hormones and gonads in men. Siberian medical review. 2013;(1):9-14. (In Russ.)]
  12. Porst H, Buvat J. Standard practice in sexual medicine. Oxford: Blackwell Publishing; 2006. 401 p.
  13. Laumann EO, Nicolosi A, Glasser DB, et al. Sexual problems among women and men aged 40-80 y: prevalence and correlates identified in the Global Study of Sexual Attitudes and Behaviors. Int J Impot Res. 2005;17(1):39-57. https://doi.org/10.1038/sj.ijir.3901250.
  14. Montorsi F, Adaikan G, Becher E, et al. Summary of the recommendations on sexual dysfunctions in men. J Sex Med. 2010;7(11):3572-3588. https://doi.org/10.1111/j.1743-6109. 2010.02062.x.
  15. Коршунов М.Н., Коршунова Е.С. Селективные ингибиторы обратного захвата серотонина и фертильный потенциал мужчины. Психиатрия и урология. На стыке смежных дисциплин // Урологические ведомости. – 2016. – Т. 6. – № 3. – C. 19–25. [Korshunov MN, Korshunova ES. Selective serotonin reuptake inhibitor and fertility potential of the men. psychiatry and urology. at the junction of related disciplines. Urologicheskie vedomosti. 2016;6(3):19-25. (In Russ.)]. https://doi.org/10.17816/uroved6319-25.
  16. Haduch A, Bromek E, Wojcikowski J, et al. Melatonin Supports CYP2D-Mediated Serotonin Synthesis in the Brain. Drug Metab Dispos. 2016;44(3):445-452. https://doi.org/10.1124/dmd.115.067413.
  17. Корнеев И.А. Терапия ИФДЭ5 при эректильной дисфункции и вопросы сердечно-сосудистой безопасности // Урологические ведомости. – 2015. – Т. 5. – № 2. – С. 28–30. [Korneev IA. Pde5 inhibitors in treatment of erectile dysfunction and cardiovascular safety. Urologicheskie vedomosti. 2015;5(2): 28-30. (In Russ.)]. https://doi.org/10.17816/uroved5228-30.
  18. Кузьмин И.В., Аюб А.Х., Слесаревская М.Н. Ингибиторы фосфодиэстеразы 5-го типа в лечении дисфункций нижних мочевых путей // Урологические ведомости. – 2020. – Т. 10. – № 1. – C. 67–74. [Kuz’min IV, Ayub AKh, Slesarevskaya MN. Phosphodiesterase type 5 inhibitors in treatment of lower urinary tract dysfunctions. Urology reports (St. - Petersburg). 2020;10(1): 67-74. (In Russ.)] https://doi.org/10.17816/uroved10167-74.
  19. Atan A, Basar MM, Tuncel A, et al. Comparison of efficacy of sildenafil-only, sildenafil plus topical EMLA cream, and topical EMLA-cream-only in treatment of premature ejaculation. Urology. 2006;67(2): 388-391. https://doi.org/10.1016/j.urology.2005.09.002.
  20. Ахвледиани Н.Д., Аляев Ю.Г. Результаты 50 % селективной пенильной денервации при лечении первичного преждевременного семяизвержения // Врач. – 2012. – № 6. – C. 37–40. [Akhvlediani ND, Alyaev YG. Results of 50 % selective penile denervation in the treatment of primary premature ejaculation. Vrach. 2012;(6):37-40 (In Russ.)]
  21. Yu AM, Idle JR, Byrd LG, et al. Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6. Pharmacogenetics. 2003;13(3):173-181. https://doi.org/10.1097/ 01.fpc.0000054066.98065.7b.
  22. Haduch A, Bromek E, Kot M, et al. The cytochrome P450 2D-mediated formation of serotonin from 5-methoxytryptamine in the brain in vivo: a microdialysis study. J Neurochem. 2015;133(1):83-92. https://doi.org/10.1111/jnc.13031.
  23. Кузьменко А.В., Кузьменко В.В., Гяургиев Т.А., Строева Д.Е. Хронобиологические аспекты применения Пролита супер септо у больных инфекционно-воспалительными заболеваниями органов мочевыделительной системы // Урология. – 2015. – № 4. – С. 19–23. [Kuz’menko AV, Kuz’menko VV, Gyaurgiev TA, Stroeva DE. Chronobiological aspects of the use of Prolit super septo in patients with infectious and inflammatory diseases of the urinary system. Urologiia. 2015;(4):19-23. (In Russ.)]
  24. Кузьменко А.В., Кузьменко В.В., Гяургиев Т.А. Хронобиологический подход к терапии хронического рецидивирующего бактериального цистита в стадии обострения // Урология. – 2017. – № 2. – С. 60–65. [Kuz’menko AV, Kuz’menko VV, Gyaurgiev TA. Chronobiological approach to managing an exacerbation of chronic recurrent bacterial cystite. Urologiia. 2017;(2):60-65. (In Russ.)] https://doi.org/10.18565/urol.2017.2.60-65.
  25. Кузьменко А.В., Кузьменко В.В., Гяургиев Т.А., Строева Д.Е. Хронобиологические аспекты применения комплекса «Нейродоз» у больных с эректильной дисфункцией // Урология. – 2014. – № 5. – С. 90–94. [Kuz’menko AV, Kuz’menko VV, Gyaurgiev TA, Stroeva DE. Chronobiological aspects of the use of complex “Neirodoz” in patients with erectile dysfunction. Urologiia. 2014;(4):90-94. (In Russ.)]

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Copyright (c) 2020 Kuzmenko A.V., Gyaurgiev T.A., Vishnyakov A.A., Tizyo D.V.

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