Kidney damage in COVID-19 patients

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Abstract

The results of the analysis of case histories of 100 deceased patients (55 women and 45 men), whose cause of death was the syndrome of multiple organ failure due to COVID-19, are presented. The case histories of patients who had no previous renal dysfunction were selected for the analysis. The average age of the patients was 76 years. At the terminal stage of the disease, microhematuria was detected in 27 patients, hypercreatininemia was noted in 17 patients, while the creatinine content in the blood did not exceed 437 μmol / L in any of 100 patients. Oliguria was observed in 9 patients, polyuria – in 43 patients. A possible cause of kidney damage is the damaging effect of SARS-CoV-2 on the proximal convoluted tubules of the nephron. At the same time, in no patient with a severe course of COVID-19, kidney damage did not determine the severity of the condition and was not the cause of death.

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About the authors

Aleksei V. Antonov

Academician I.P. Pavlov First St. Petersburg State Medical University; City Hospital of the Holy Great Martyr George

Author for correspondence.
Email: endour@mail.ru

Dr. Sci. (Med), Professor of the Department of Urology

Russian Federation, 6-8 Lva Tolstogo str., Saint Petersburg, 197022; Saint Petersburg

Anton S. Vorob'ev

City Hospital of the Holy Great Martyr George

Email: skorobej21@mail.ru

urologist

Russian Federation, Saint-Petersburg

References

  1. Kul’chavenja EV, Holtobin DP, Nejmark AI. The working of the urology department during the covid-19 epidemic. Urology Reports (St. Petersburg). 2020;10(4):301–307. doi: 10.17816/uroved52792
  2. World Health Organization. Coronavirus disease 2019 (COVID-19) Situation Report – 51 Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200311-sitrep-51-covid-19.pdf
  3. Iacobucci G. COVID-19: all non-urgent elective surgery is suspended for at least three months in England. BMJ. 2020;368: m1106. doi: 10.1136/bmj.m1106
  4. Naspro R, Da Pozzo LF. Urology in the time of corona. Nat Rev Urol. 2020;17:251–253. doi: 10.1038/s41585-020-0312-1
  5. Zumla A, Chan JF, Azhar EI, et al. Coronaviruses – drug discovery and therapeutic options. Nat Rev Drug Discov. 2016;15(5): 327–347. doi: 10.1038/nrd.2015.37
  6. He F, Deng Y, Li W. Coronavirus Disease 2019: what we know? J Med Virol. 2020;92(7):719–725. doi: 10.1002/jmv.25766
  7. Zumla A, Niederman MS. The explosive epidemic outbreak of novel coronavirus disease 2019 (COVID-19) and the persistent threat of respiratory tract infectious diseases to global health security. Curr Opin Pulm Med. 2020;26(3):193–196. doi: 10.1097/MCP.0000000000000676
  8. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11)1061–1069. doi: 10.1001/jama.2020.1585
  9. Kupferschmidt K, Cohen J. China’s COVID-19 strategy work elsewhere? Science. 2020;367(6482):1061–1062. doi: 10.1126/science.367.6482.1061
  10. Livingston E, Bucher K. Coronavirus disease 2019 (COVID-19) in Italy. JAMA. 2020;323(14):1335. doi: 10.1001/jama.2020.4344
  11. Lin L, Lu L, Cao W, Li T. Hypothesis for potential pathogenesis of SARS-CoV-2 infection – a review of immune changes in patients with viral pneumonia. Emerg Microbes Infect. 2020;9(1):727–732. doi: 10.1080/22221751.2020.1746199
  12. Zou X, Chen K, Zou J, et al. Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Front Med. 2020;14(2):185–192. doi: 10.1007/s11684-020-0754-0
  13. Chu KH, Tsang WK, Tang CS, et al. Acute renal impairment in coronavirus-associated severe acute respiratory syndrome. Kidney Int. 2005;67(2):698–705. doi: 10.1111/j.1523-1755.2005.67130.x
  14. Cheng Y, Luo R, Wang K, et al. Kidney impairment is associated with inhospital death of COVID-19 patients. Kidney Int. 2020;97(5):829–838. doi: 10.1016/j.kint.2020.03.005
  15. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054–1062. doi: 10.1016/S0140-6736(20)30566-3
  16. Rybakova MG, Karev VE, Kuznecova IA. Anatomical Pathology of Novel Coronavirus (COVID-19) Infection. First Impressions. Arkhiv Patologii. 2020;82(5):5–15. doi: 10.17116/patol2020820515

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