Cutaneous manifestations of ANCA-associated vasculitis and immunosuppressive therapy: cause-effect relationships (a case report)

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Granulomatosis with polyangiitis, formerly known as Wegener’s granulomatosis, is an autoimmune ANCA-associated systemic vasculitis characterized by extensive damage to multiple organs and systems. Besides a typical clinical triad of ENT, lungs, and kidneys injury, various types of skin lesions can be found in 10–50% of cases. A severe course of the disease and low survival of patients often requires using aggressive treatment in a form of combined immunosuppressive therapy. On the one hand, it generally improves the prognosis, and on the other is itself associated with numerous complications. One of them is a secondary infection. Skin is the second most common localization of infection after the respiratory system. Preceding skin lesions caused by vasculitis may increase the risk of infection. Thus, patients with ANCA-associated vasculitis should be carefully observed for cutaneous manifestation, both before and during the immunosuppressive therapy.

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About the authors

Madina A. Kitova

Municipal Out-Patient Department No 93


Russian Federation, Saint Petersburg

rheumatologist, Municipal out-patient department №93

Maksim V. Maksimov

Pavlov University


Russian Federation, Saint Petersburg

PhD (Medicine), associate professor, Hospital Therapy Department


Valeriy N. Marchenko

Pavlov University

ORCID iD: 0000-0002-2440-7222
SPIN-code: 1711-4150
Scopus Author ID: 57206419660

Russian Federation, Saint Petersburg

PhD (Medicine), Professor, Hospital Therapy Department

Elena A. Bruchkus

Pavlov University


Russian Federation, Saint Petersburg

Head of the Second Cardiology Department, Scientific Research Institute of Rheumatology and Allergology of the Scientific and Clinical Research Center

Denis A. Davydov

Pavlov University

Author for correspondence.
ORCID iD: 0000-0002-5524-1616
SPIN-code: 1132-5294
Scopus Author ID: 57217159189

Russian Federation, Saint Petersburg

resident, Hospital Therapy Department


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Supplementary files

Supplementary Files Action
Fig. 1. Crusted ulcerative defects of the left shin

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Fig. 2. Weeping ulcer in the left inframammary fold

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Fig. 3. Fibrin-covered ulcer in the sacral region

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Fig. 4. Ulcer with detritus behind the left ear

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Copyright (c) 2020 Kitova M.A., Maksimov M.V., Marchenko V.N., Bruchkus E.A., Davydov D.A.

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