Paraneoplastic neurological syndrome in onset of Hodgkin lymphoma

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Abstract

Hodgkin lymphoma is a malignant disease with clonal proliferation of B-cells and high-level reactive inflammatory microenvironment. The main clinical sings are lymphadenopathy and toxic symptoms. Neurological symptoms as usual can be a result of compression or tumor infiltration of nervous structures. The primary damage of CNS occurs from 0,2% to 0,5% of all cases HL.

Paraneoplastic neurological syndrome is a group of rare (an average 1 case on 10000 patients) neurological disorders against the background of oncological process. The pathophysiologic mechanism is due to production of antibody which is both to tumor cells and nerve cells. These antibodies are called onconeural autoantibodies. The hallmark which make diagnostics harder is the fact that onconeural autoantibodies rare take place in patients with lymphomas unless anti-Tr and anti-mGluR1 in patients with limbic encephalitis or paraneoplastic cerebellar degeneration.

There are two case reports about patients with PNS in onset of Hodgkin lymphoma in article.

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About the authors

Elena S. Pavlyuchenko

North-Western State Medical University named after I.I. Mechnikov

Author for correspondence.
Email: Elena.Pavlyuchenko@szgmu.ru
SPIN-code: 7123-1626
Russian Federation, 41 Kirochnaya str., Saint Petersburg, 191015

Alexander A. Mirsaitov

North-Western State Medical University named after I.I. Mechnikov

Email: aleksandr.mirsaitov@gmail.com
SPIN-code: 7708-5592
Russian Federation, 41 Kirochnaya str., Saint Petersburg, 191015

Mariya N. Diakonova

North-Western State Medical University named after I.I. Mechnikov

Email: dec.dmn@gmail.com
Russian Federation, 41 Kirochnaya str., Saint Petersburg, 191015

Egor A. Karev

North-Western State Medical University named after I.I. Mechnikov

Email: Egor.Karev@klinikum-lippe.de
Germany, 41 Kirochnaya str., Saint Petersburg, 191015

References

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Supplementary files

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1. Fig. 1. Magnetic resonance tomography — diffuse changes in brain substance with features of active pathological process: a — axial section, convexital surface; b — axial section, level of basal nuclei (diffuse changes in the structure of the cerebellar stalks); c — frontal section (focal areas of accumulation of contrast agent in the right frontal lobe); d — axial section, convexital surface (focal areas of accumulation of contrast material in the right frontal lobe)

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2. Fig. 2. Magnetic resonance tomography — diffuse changes in brain substance without features of active pathological process: a — axial section at the level of the lateral ventricles; b — axial section at the level of the anterior horns; c — axial section, the level of the posterior horns of the lateral ventricles; d — axial section, convexital surface

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Copyright (c) 2021 Pavlyuchenko E.S., Mirsaitov A.A., Diakonova M.N., Karev E.A.

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