Disorders of lipid metabolism in the liver in patients with chronic viral hepatitis

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Abstract

The review article is devoted to the problem of lipid metabolism disorders in the liver in patients with chronic hepatitis B and chronic hepatitis C. The results of modern biological, epidemiological and clinical studies aimed at studying the causes and mechanisms of the formation of liver steatosis and steatohepatitis, their prevalence and influence on the course of infectious pathology are presented. Particular attention is paid to the generalization and systematization of the currently available data on the mechanisms of lipid metabolism disorders in the liver, mediated by the molecular structures of hepatitis B and C viruses. In conclusion, the need for timely diagnosis and treatment of pathological conditions caused by the development of lipid metabolism disorders in the liver is substantiated in order to increase the quality of medical care for patients with chronic hepatitis B and C.

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About the authors

Valeriy V. Tsvetkov

Smorodintsev Research Institute of Influenza

Author for correspondence.
Email: suppcolor@gmail.com
ORCID iD: 0000-0001-5195-9316
SPIN-code: 6562-9851

MD, Cand. Sci. (Med.)

Russian Federation, 15/17 Professor Popova str., Saint-Petersburg, 197376

Ivan I. Tokin

Smorodintsev Research Institute of Influenza;North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russia

Email: ivan.tokin@influenza.spb.ru
ORCID iD: 0000-0002-9824-3945
SPIN-code: 2496-9920

MD, Cand. Sci. (Med.)

Russian Federation, 15/17 Professor Popova str., Saint-Petersburg, 197376; 41 Kirochnaya str., Saint Petersburg, 191015

Olesya E. Nikitina

Smorodintsev Research Institute of Influenza

Email: olesya.nikitina@influenza.spb.ru
ORCID iD: 0000-0001-5506-9919
SPIN-code: 2478-0403

MD, Cand. Sci. (Med.)

Russian Federation, 15/17 Professor Popova str., Saint-Petersburg, 197376

Dmitry A. Lioznov

Smorodintsev Research Institute of Influenza; Pavlov First Saint Petersburg State Medical University

Email: dlioznov@yandex.ru
ORCID iD: 0000-0003-3643-7354
SPIN-code: 3321-6532

MD, Dr. Sci. (Med.)

Russian Federation, 15/17 Professor Popova str., Saint-Petersburg, 197376; Saint-Petersburg

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2. Figure. Lipid metabolism in the hepatocyte: LD — lipid droplets; VLDL — very low density lipoproteins; ATGL / PNPLA-2 — patatin-like phospholipase domain-containing protein 2; ChREBP — carbohydrate response element binding protein; CIDE — cell death-inducing DNA fragmentation factor alpha-like effector; DGAT-2 — diacylglycerol O-acyltransferase 2; GPAT-4 — glycerol-3-phosphate acyltransferase 4; SREBP-1 — sterol regulatory element binding protein 1

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Copyright (c) 2021 Tsvetkov V.V., Tokin I.I., Nikitina O.E., Lioznov D.A.

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