CAPABILITIES AND PERSPECTIVES OF THE PRENATAL NEUROSURGERY(FETAL NEUROSURGERY)



Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Capabilities and perspectives of the prenatal neurosurgery in hydrocephalus and myelomeningocele are presented, which were based on experimental and clinical studies. Reasons of the decreasing of interest for surgical treatment of hydrocephalus and «revolution» in the field of surgical treatment of fetus myelomeningocele are analyzed. Requirements to medical centers that are planing the introduction of technologies of surgical treatment of myelomeningocele are presented. Prospects of introducing of the technology in fetal neurosurgery in St. Petersburg are analyzed.

Full Text

Restricted Access

About the authors

A S Iova

North-Western State Medical university named after I.I. Mechnikov

Y A Garmachov

North-Western State Medical university named after I.I. Mechnikov

E Y Crukov

North-Western State Medical university named after I.I. Mechnikov

D A Iova

North-Western State Medical university named after I.I. Mechnikov

References

  1. Harrison, M.R. Fetal surgery for congenital hydronephrosis / M.R. Harrison [et al.] // N Engl J Med. - 1982. - Vol. 306. - P. 591-593.
  2. Adzick, N. S. A randomized trial of prenatal versus postnatal repair of myelomeningocele / N. S. Adzick [et al.] // N Engl J Med. - 2011. - Vol. 364. - P. 993-1004.
  3. Hedrick, H. L. Sacrococcygeal teratoma: prenatal assessment, fetal intervention, and outcome / H. L. Hedrick [et al.] // J Pediatr Surg. - 2004. - Vol. 39. - P. 430-438.
  4. Hirose, S. Fetal surgery for sacrococcygeal teratoma / S. Hirose [et al.] // Clin Perinatol. - 2003. - Vol. 30. - P. 493-506.
  5. Jani, J. C. Severe diaphragmatic hernia treated by fetal endoscopic tracheal occlusion / J. C. Jani [et al.] // Ultrasound Obstet Gynecol. - 2009. - Vol. 34. - P. 304-310.
  6. Kitano, Y. Open fetal surgery for life-threatening fetal malformations / Kitano Y. [et al.] // Semin Perinatol. - 1999. - Vol. 23. - P. 448-461.
  7. Vrecenak, J. D. Fetal surgical intervention: progress and perspectives / J. D. Vrecenak, A. W. Flake // Pediatr Surg Int. - 2013. - Vol. 29. - P. 407-417.
  8. Levene, M.I. Fetal and neonatal neurology and neurosurgery / Ed. by M.I. Levene - Edinburg etc.: Churchill Livingston, 2009. - 960 p.
  9. Иова, А.С. Высокотехнологичная медицинская помощь при нейрохирургической патологии у плодов и новорожденных (перспективы перинатальной и неонатальной нейрохирургии) / А.С. Иова, Ю.А. Гармашов, Е.Ю. Крюков, Щугарева Л.М. // Тезисы Всерос. научн-практ. конф. Поленовские чтения, 2009. - С. 326-327.
  10. Трофимова, Т.Н. Лучевые исследования головного мозга плода и новорожденного / Т.Н. Трофимова, Д.В. Воронин, А.Д. Халиков, А.С. Иова и др. - СПб, 2011. - 195 с.
  11. Крюков, Е.Ю. Оптимизация медицинской помощи при нейрохирургической патологии, выявленной у плодов и новорожденных: Автореф. докт. дисс. - СПб., 2012. - 35 с.
  12. Michejda, M. In utero diagnosis and treatment of non-human primate fetal skeletal anomalies / M. Michejda, G. D. Hodgen // 1. Hydrocephalus. JAMA. - 1981. - Vol. 246. - P. 1093- 1097.
  13. Glick, P. L. Correction of congenital hydrocephalus in utero. Ii. Efficacy of in utero shunting // P. L. Glick [et al.] // J Pediatr Surg. - 1984. - Vol. 19. - P. 870- 881.
  14. Birnholz, J. C. Antenatal treatment of hydrocephalus / J. C. Birnholz, F. D. Frigoletto // N Engl J Med. - 1981. - Vol. 303. - P. 1021- 1023.
  15. Cromblehome, T. M. Invasive fetal therapy: Current status and future directions // Semin. Perinatol. - 1994. - Vol. 18. - P. 385-397.
  16. Milhorat T. H. Pediatric neurosurgery / Philadelphia, PA:FADavis, 1978. - P. 112- 121.
  17. Clewell, W. H. A surgical approach to the treatment of hydrocephalus / W. H. Clewell [et al.] // N Engl J Med. - 1982. - Vol. 306. - P. 1320-325.
  18. Duncan, C. C. Fetal hydrocephalus: An approach to management / C. C. Duncan [et al.] // Presented at the 32nd Annual Meeting of the Congress of Neurological Surgeons, Toronto, 1982. - P. 3-8.
  19. Frigoletto, F. D. Antenetal treatment of hydrocephalus by ventriculoamniotic shunting / F. D. Frigoletto, J. C. Birnholz, M. F. Greene // N Engl J Med. - 1982. - Vol.248. - P. 2496- 2497.
  20. Depp, R. Fetal surgery for hydrocephalus: successphul in utero ventriculoamniotic shunt for Dandy-Walker syndrome / Depp R. [et al.] // Obstet Gynecol. - 1983. - Vol.61. - P. 710-714.
  21. Adzick, N. S. Fetal surgical therapy / N. S. Adzick, M. R.Harrison // Lancet. - 1994. - Vol. 343. - P. 897 - 902.
  22. Bruner, J. P. Fetal surgery for myelomeningocele and the incidence оf shunt-dependent hydrocephalus / J. P. Bruner [et al.] // JAMA. - 1999. - Vol. 282. - P. 1819-1825.
  23. Cavalheiro, S. Fetal hydrocephalus / S. Cavalheiro [et al.] //Child's Nervous System. 2011. - Vol. 27. - P.1575-583.
  24. Patten, B. M. Embryological stages in the establishing of myeloschisis with spina bifida // Am J Anat. - 1953. - Vol. 93. P. 365-395.
  25. Cameron, A. H. The spinal cord lesion in spina bifida cystica // Lancet (1956) - Vol.271. - P. 171-174.
  26. Hutchins, G. M. Spinal dysraphia: not a neural tube defect? // G. M. Hutchins, K. D. McGowan, K. J. Blakemore // Am J Hum Genet. - 1992. - Vol. 51. - A319.
  27. Hutchins, G. M. Acquired spinal cord injury in human fetuses with myelomeningocele / G. M. Hutchins [et al.] // Pediatr Pathol Lab Med. - 1996. - Vol. 16. - P. 701-712.
  28. Heffez, D. S. The paralysis associated with myelomeningocele: clinical and experimental data implicating a preventable spinal cord injury / D. S. Heffez [et al.] //Neurosurgery. - 1990. - Vol. 26. - P. 987-992.
  29. Heffez, D. S. Intrauterine repair of experimental surgically created dysraphism / D. S. Heffez [et al.] // Neurosurgery. - 1993. - Vol. 32. - P. 1005-1010.
  30. Jordan, M. A. The relationships of the spinal cord and meninges in meningocele, meningomyelocele and iniencephaly / M. A. Jordan, D. S. Heffez, G. M. Hutchins. - Teratology - 1991. - Vol. 43. - P. 472.
  31. Meuli, M. The spinal cord lesion in human fetuses with myelomeningocele: implications for fetal surgery / M. Meuli [et al.] // J Pediatr Surg. - 1997. - Vol. 32. - P. 448-452.
  32. Michejda, M. Intrauterine treatment of spina bifida: primate model // Z Kinderchir. - 1984. - Vol. 39. - P. 259-261.
  33. Housley, H. T. Creation of myelomeningocele in the fetal rabbit / H. T. Housley [et al.] // Fetal Diagn Ther. - 2000. - Vol. 15. - P. 275-279.
  34. Meuli, M. In utero surgery rescues neurological function at birth in sheep with spina bifida / M. Meuli [et al.] // Nat Med. - 1995. - Vol. 1. - P. 342-347.
  35. Meuli, M. Creation of myelomeningocele in utero: a model of functional damage from spinal cord exposure in fetal sheep / M. Meuli [et al.] // J Pediatr Surg. - 1995. - Vol. 30. - P. 1028-1032.
  36. Meuli, M. In utero repair of experimental myelomeningocele saves neurological function at birth / M. Meuli [et al.] // J Pediatr Surg. - 1996. - Vol. 31. - P. 397-402.
  37. Stiefel, D. Fetal spina bifida in a mouse model: loss of neural function in utero / D. Stiefel, A. J. Copp, M. Meuli // J Neurosurg. - 2007. - Vol. 106. - P. 213-221.
  38. Meuli-Simmen, C. Fetal reconstructive surgery: experimental use of the latissimusdorsi flap to correct myelomeningocele in utero / C. Meuli-Simmen [et al.] // Plast Reconstr Surg. - 1995. - Vol. 96. - P. 1007-1011.
  39. Danzer E. Structural and functional characterization of bladder smooth muscle in fetal rats with retinoic acid-induced myelomeningocele / E. Danzer, [et al.] //Am J Physiol Renal Physiol. - 2007. - Vol. 292. - P. 197-206.
  40. Danzer, E. Morphologic analysis of the neuromuscular development of the anorectal unit in fetal rats with retinoic acidi nduced myelomeningocele / E.Danzer [et al.] // Neurosci Lett. - 2008. - Vol.430. - P. 157-162.
  41. Danzer, E. Amniotic fluid levels of glial fibrillary acidic protein in fetal rats with retinoic acid induced myelomeningocele: a potential marker for spinal cord injury / E.Danzer [et al.] // Am J Obstet Gynecol. - 2011. - Vol. 204. - P. 178.
  42. Encinas, J. L. Maldevelopment of the cerebral cortex in the surgically induced model of myelomeningocele: implications for fetal neurosurgery / J. L. Encinas [et al.] // J Pediatr Surg. - 2011. - Vol. 46. - P. 713-722.
  43. Stiefel, D. Scanning electron microscopy of fetal murine myelomeningocele reveals growth and development of the spinal cord in early gestation and neural tissue destruction around birth / D. Stiefel, M. Meuli // J Pediatr Surg. - 2007. - Vol. 42. - P. 1561-1565.
  44. Shen, J. Morphology of nervous lesion in the spinal cord and bladder of fetal rats with myelomeningocele at different gestational age / J. Shen, G. Zhou, H. Chen // J Pediatr Surg. - 2013. - Vol. 48. - P. 2446-2452.
  45. Bouchard S. Correction of hindbrain herniation and anatomy of the vermis after in utero repair of myelomeningocele in sheep / S. Bouchard [et al.] //J Pediatr Surg. - 2003. - Vol. 38. - P. 451-458.
  46. Paek, B. W. Hindbrain herniation develops in surgically created myelomeningocele but is absent after repair in fetal lambs / B. W. Paek [et al.] //Am J Obstet Gynecol. - 2000. - Vol. 183. - P. 1119-1123.
  47. Bruner, J. P. Endoscopic coverage of fetal open myelomeningocele in utero / J. P. Bruner, N. E. Tulipan, W. O. Richards // Am J Obstet Gynecol. - 1997. - Vol. 176. - P. 256-257.
  48. Adzick, N. S. Successful fetal surgery for spina bifida / N. S. Adzick [et al.] // Lancet. - 1998. - Vol. 352. - P. 1675-1676.
  49. Bruner, J. P. Fetal surgery for myelomeningocele and the incidence of shunt-dependent hydrocephalus / J. P. Bruner [et al.] // JAMA. - 1999. - Vol. 282. - P. 1819-1825.
  50. Sutton, L. N. Improvement in hindbrain herniation demonstrated by serial fetal magnetic resonance imaging following fetal surgery for myelomeningocele / L. N. Sutton [et al.] // JAMA. - 1999. - Vol. 282. - P. 1826-1831.
  51. Johnson, M. P. Fetal myelomeningocele repair: short-term clinical outcomes / M.P. Johnson [et al.] //Am J Obstet Gynecol. - 2003. - Vol. 189. - P. 482-487.
  52. Rintoul, N. E. A new look at myelomeningoceles: functional level, vertebral level, shunting, and the implications for fetal intervention / N. E. Rintoul [et al.] // Pediatrics. - 2002. - Vol. 109. - P. 409-413.
  53. Danzer, E. Fetal head biometry assessed by fetal magnetic resonance imaging following in utero myelomeningocele repair / E. Danzer [et al.] // Fetal Diagn Ther. - 2007. - Vol. 22. - P. 1-6.
  54. Danzer, E. Reversal of hindbrain herniation after maternal-fetal surgery for myelomeningocele subsequently impacts on brain stem function / E. Danzer [et al.] // Neuropediatrics. - 2008. - Vol. 39. - P. 359-362.
  55. Danzer, E. Lower extremity neuromotor function and short-term ambulatory potential following in utero myelomeningocele surgery / E. Danzer [et al.] // Fetal Diagn Ther. - 2009 - Vol. 25. - P. 47-53.
  56. Danzer, E. Preschool neurodevelopmental outcome of children following fetal myelomeningocele closure / E. Danzer [et al.] // Am J Obstet Gynecol. - 2010. - Vol. 202. - P. 450-459.
  57. Johnson, M. P. Maternal-fetal surgery for myelomeningocele: neurodevelopmental outcomes at 2 years of age / M. P. Johnson [et al.] // Am J Obstet Gynecol. - 2006. - Vol. 194. - P. 1145-1150.
  58. Danzer, E. Intradural inclusion cysts following in utero closure of myelomeningocele: clinical implications and follow-up findings / E. Danzer [et al.] // J Neurosurg Pediatr. - 2008. - Vol. 2. - P. 406-413.
  59. Clayton, D. B. Long-term urological impact of fetal myelomeningocele closure / D. B. Clayton [et al.] // J Urol. - 2011. - Vol. 186. - P. 1581-1585.
  60. Shapiro, E. Altered smooth muscle development and innervation in the lower genitourinary and gastrointestinal tract of the male human fetus with myelomeningocele / E. Shapiro [et al.] // J Urol. - 1998. - Vol. 160. - P. 1047-1053.
  61. Tubbs, R. S. Late gestational intrauterine myelomeningocele repair does not improve lower extremity function / R. S. Tubbs [et al.] // Pediatr Neurosurg. - 2003. - Vol. 38. - P. 128-132.
  62. Wilson, R. D. Reproductive outcomes after pregnancy complicated by maternal-fetal surgery / R. D. Wilson [et al.] // Am J Obstet Gynecol. - 2004. - Vol. 191. - P. 1430-1436.
  63. Wilson, R. D. Reproductive outcomes in subsequent pregnancies after a pregnancy complicated by open maternal-fetal surgery (1996-2007) / R. D. Wilson [et al.] // Am J Obstet Gynecol. - 2010. - Vol. 203. - P. 209.
  64. Roberts, D. Interventions for the treatment of twin-twin transfusion syndrome / D. Roberts [et al.] // Cochrane Database Syst Rev 1. - 2014. - CD002073.
  65. Cannie, M. M. Evidence and patterns in lung response after fetal tracheal occlusion: clinical controlled study / M. M. Cannie [et al.] // - Radiology. - 2009. - Vol. 252. - P. 526-533.
  66. Bruner, J. P. Endoscopic coverage of fetal myelomeningocele in utero / J.P. Bruner, W.O. Richards, N.B. Tulipan, T.L. Arney // Am J Obstet Gynecol. - 1999. - Vol. 180. - P. 153-158.
  67. Bruner, J. P. In utero repair of myelomeningocele: a comparison of endoscopy and hysterotomy / J.P. Bruner [et al.] // Fetal Diagn Ther. - 2000. - Vol. 15. - P. 83-88.
  68. Farmer, D. L. In utero repair of myelomeningocele: experimental pathophysiology, initial clinical experience, and outcomes / D.L. Farmer [et al.] // Arch Surg. - 2003. - Vol. 138. - P. 872-878.
  69. Degenhardt J. Percutaneous minimally-invasive fetoscopic surgery for spina bifida aperta. Part II Maternal management and outcome / J. Degenhardt [et al.] // Ultrasound Obstet Gynecol. - 2014. - Vol. 44 (5). 525-531.
  70. Kohl, T. Current status and prospects of fetoscopic surgery for spina bifida in human fetuses. Response to Fichter et al.: Fetal spina bifida repair-current trends and prospects of intrauterine neurosurgery (Fetal Diagn Ther. - 2008. - Vol.23: P. 271-286.) / T. Kohl, U.Gembruch // Fetal Diagn Ther. - 2008. - Vol. 24. - P. 318-320.
  71. Kohl, T. Partial amniotic carbondioxide insufflation (PACI) during minimally invasive fetoscopic surgery: early clinical experience in humans / T. Kohl [et al.] // Surg Endosc. - 2010. - Vol. 24. - P. 432-444.
  72. Kohl, T. Percutaneous fetoscopic patch closure of human spina bifida aperta: advances in fetal surgical techniques may obviate the need for early postnatal neurosurgical intervention / T. Kohl [et al.] // Surg Endosc. - 2009. - Vol. 23. - P. 890-895.
  73. Verbeek, R. J. Fetal endoscopic myelomeningocele closure preserves segmental neurological function / R. J. Verbeek [et al.] // Dev Med Child Neurol. - 2012. - Vol. 54. - P. 15-22.
  74. Verbeek, R. J. Does fetal endoscopic closure of the myelomeningocele prevent loss of neurologic function in spina bifida aperta? / R. J. Verbeek, A. Heep, N. M. Maurits // Cereb Fluid Res. - 2010. - Vol. 7. - P. 1-2.
  75. Shurtleff, D. Fetal endoscopic myelomeningocele repair // Dev Med Child Neurol. - 2012. - Vol. 54. - P. 4-5.
  76. Cohen A. R. Position statement on fetal myelomeningocele repair / A.R. Cohen [et al.] // Am J Obstet Gynecol. - 2014. - Vol. 210. - P. 107-111.
  77. Kahn, L. Fetal surgery: the ochsner experience with in utero spina bifida repair / L. Kahn [et al.] // Ochsner. J. - 2014. - Vol.14. - P. 112-118.
  78. Hisaba, W. J. Intrauterine myelomeningocele repair postnatal results and follow-up at 3.5 years of age-initial experience from a single reference service in Brazil / W. J. Hisaba [et al.] // Childs Nerv Syst. - 2012. - Vol. 28. - P. 461-467.
  79. Macedo, A. Jr. Urological evaluation of patients that had undergone in utero myelomeningocele closure: a prospective assessment at first presentation and early follow-up. Do their bladder benefit from it? / A. Jr. Macedo [et al.] // Neurourol Urodyn. - 2014. [Epub ahead of print].
  80. Faria, T. C. Improvement of motor function and decreased need for postnatal shunting in children who had undergone intrauterine myelomeningocele repair / T. C. Faria [et al.] // Arq Neuropsiquiatr. - 2013. - Vol. 71. - P. 604-608.
  81. Zamlyniski, J. Perinatal results of intrauterine open fetal surgery of fetuses diagnosed with myelomeningocele - the clinical report of ten cases / J. Zamlyniski [et al.] // Ginekol Pol. - 2007. - Vol. 78. - P. 647-651.
  82. Meuli, M. Fetal surgery in Zurich: key features of our first open in utero repair of myelomeningocele / M. Meuli [et al.] // Eur J Pediatr Surg. - 2012. - Vol. 23(6). - P. 494-498.
  83. Meuli, M. Premiere use of Integra artificial skin to close an extensive fetal skin defect during open in utero repair of myelomeningocele / M. Meuli [et al.] // Pediatr Surg Int. - 2013. - Vol. 29(12). - P.1321-1326.
  84. Osinga R. Assessment of long-term donor site morbidity after harvesting the latissimusdorsi flap for neonatal myelomeningocele repair / R. J Osinga [et al.] // Plast Reconstruct Aesth Surg. - 2014 (in press).
  85. Watanabe, M. A tissue engineering approach for prenatal closure of myelomeningocele with gelatin sponges incorporating basic fibroblast growth factor / M. Watanabe [et al.] //Tissue Eng. - 2010. - Part A Vol. 16. - P. 1645-1655.
  86. Watanabe, M. A tissue engineering approach for prenatal closure of myelomeningocele: comparison of gelatin sponge and microsphere scaffolds and bioactive protein coatings / M. Watanabe [et al.] / Tissue Eng. - 2011. - Part A Vol.17. - P. 1099-1110.
  87. Meuli, М. Fetal surgery for myelomeningocele is effective: a critical look at the whys / М. Meuli, U. Moehrlen // Pediatr Surg Int. - 2014. - Vol. 30 (7) - P. 689- 697.
  88. Mikhailov, A. Ultrasound directed intrauterine invasive procedures for diagnosis and treatment purposes / A. Mikhailov, T. Pigina, V. Lebedev // 5 Int. Cong. Erly Fetal Diagn.- Prague, 1990. - P.182.
  89. Приказ Министерства здравоохранения РФ от 10 декабря 2013 г. № 916н «О перечне видов высокотехнологичной медицинской помощи».
  90. Mikhailov, A. Spinal neural tube defects: prenatal diagnosis, counseling, care and perspectives / A. Mikhailov, A. Iova, D. Voronin, D. Iova // 1st Open fetal surgery for myelomeningocele /Sils,Switzerland. - 2015 (http://www.ecfs.ch/home/login.html).

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2015 Iova A.S., Garmachov Y.A., Crukov E.Y., Iova D.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 71733 от 08.12.2017.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies