CLINICAL SIGNIFICANCE OF MICRORNA-21 ExPRESSION IN MONITORINGOF TUMOR PROGRESSION WITH CEREBRAL GLIOMAS



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Abstract

The early verifying of cerebral ’s gliomas progression is an actual problem. It was found that the level of mircroRNA-21 expression is a highly specific in a tumor’s evolutional process. That the aim of the study was the assessment with level of mircroRNA-21 expression in blood and saliva of patients with cerebral glioma progression and patients without it which were verified by PET using [ 11C] methionine. It was found that in majority of cases, the negative dynamics of cerebral neoplastic lesions coincided with an increase in metabolic changes in the residual glioma and highly correlated with the level of mircroRNA-21 expression. This allows us to consider a highly significant the level of mircroRNA-21 expression as a screening technique in monitoring the evolution of the tumor process and the effectiveness of the treatment.

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About the authors

R Yu Seliverstov

N.P. Bekhtereva Institute of the Human Brain of the Russian Academy of Sciences; North-Western State Medical University named after I.I. Mechnikov

M I Zarayskiy

First Pavlov State Medical University of St. Peterburg

A A Sazanov

First Pavlov State Medical University of St. Peterburg

E E Zueva

First Pavlov State Medical University of St. Peterburg

S V Lobzyn

North-Western State Medical University named after I.I. Mechnikov

A F Gurchin

N.P. Bekhtereva Institute of the Human Brain of the Russian Academy of Sciences

N V Sterlikova

N.P. Bekhtereva Institute of the Human Brain of the Russian Academy of Sciences

K P Gaidaenko

N.P. Bekhtereva Institute of the Human Brain of the Russian Academy of Sciences

M B Volov

N.P. Bekhtereva Institute of the Human Brain of the Russian Academy of Sciences

O I Tymonina

North-Western State Medical University named after I.I. Mechnikov

N V Tolstyh

N.P. Bekhtereva Institute of the Human Brain of the Russian Academy of Sciences

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Copyright (c) 2015 Seliverstov R.Y., Zarayskiy M.I., Sazanov A.A., Zueva E.E., Lobzyn S.V., Gurchin A.F., Sterlikova N.V., Gaidaenko K.P., Volov M.B., Tymonina O.I., Tolstyh N.V.

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