Differential diagnosis of thrombocytosis: a case study

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The article presents a clinical case of an unclassifiable myeloproliferative neoplasm in a 65-year old patient. Platelet count is not a criteria for differential diagnosis of reactive and tumor processes. A typical course of the disease is associated with the persistence of symptoms of microcirculation disorder against the background of previous asymptomic thrombocytosis for several years. The diagnosis of an unclassifiable myeloproliferative neoplasm is established by a combination of clinical, laboratory, instrumental, molecular genetic and morphological methods of research.

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作者简介

Aleg Budai

North-Western State Medical University named after I.I. Mechnikov

编辑信件的主要联系方式.
Email: aleg.buday@mail.ru

MD, Cand. Sci. (Med.), Assistant Professor

俄罗斯联邦, 41 Kirochnaya St., Saint Petersburg, 191015

Sergei Ermolov

North-Western State Medical University named after I.I. Mechnikov

Email: s.j.ermolov@mail.ru
ORCID iD: 0000-0002-7053-1478

MD, Dr. Sci. (Med.), Professor

俄罗斯联邦, Saint Petersburg

Valerii Dobritca

North-Western State Medical University named after I.I. Mechnikov

Email: valeriy-pav-dobritsa@yandex.ru
ORCID iD: 0000-0003-2767-936X
SPIN 代码: 7386-3984

MD, Dr. Sci. (Med.), Professor

俄罗斯联邦, Saint Petersburg

Inna Ilyashevich

North-Western State Medical University named after I.I. Mechnikov

Email: Inna.Ilyashevich@szgmu.ru
ORCID iD: 0000-0002-5784-2634
SPIN 代码: 3212-7518

MD, Cand. Sci. (Med.), Assistant Professor

俄罗斯联邦, Saint Petersburg

Anna Apresyan

North-Western State Medical University named after I.I. Mechnikov

Email: anna.apresyan@szgmu.ru
ORCID iD: 0000-0003-0637-9384
SPIN 代码: 8654-7705

MD, Cand. Sci. (Med.), Assistant Professor

俄罗斯联邦, Saint Petersburg

参考

  1. Melikyan AL, Kovrigina AM, Subortseva IN, et al. National clinical guidelines for the diagnosis and treatment of Ph-negative myeloproliferative diseases (polycythemia vera, essential thrombocythemia, primary myelofibrosis) (Edition 2020). Clinical oncohematology. 2021;14(2):264–298. (In Russ.)
  2. Abdulkadyrov KM, Shuvaev VA, Martynkevich IS, et al. Modern concept of diagnosis and management of essential thrombocytemia. Bulletin of Hematology. 2014;10(1):4–33. (In Russ.)
  3. Bogdanov AN, Tyrenko VV, Noskov YA, Semelev VN. Differentsial’naya diagnostika trombotsitozov v klinicheskoi praktike. Bulletin of the Russian Military Medical Academy. 2014;46(2):44–50. (In Russ.)
  4. Sokolova NA. Differentsial’naya diagnostika trombotsitozov. In: Gematologicheskie issledovaniya i laboratornoe obespechenie transfuziologii (prakticheskoe posobie). 2015. P. 2–15.
  5. Mikhailova ZD, Cherepanova VV. Thrombocytoses in the practice of nephrology as the cause of thrombohemorrhagic complications. Clinical nephrology. 2021;3:61–65. (In Russ.) doi: 10.18565/nephrology.2021.3.61-65
  6. Bagrova IV, Kukharchik GA, Serebryakova VI, et al. Modern approaches to the diagnosis of pulmonary embolism. Phlebology. 2012;6(4):35–42. (In Russ.)
  7. Skoda RC. Thrombocytosis. ASH Education program book. 2009:(1):159–167.
  8. Vannucchi AM, Barbui T. Thombocytosis and thrombosis. ASH Education program book. 2007;1:363–370.

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