Vol 11, No 4 (2013)

Nowadays a significant attention is currently given to the process of glycation which plays an important role in the pathogenesis of vascular complications of diabetes and different neurodegenerative diseases. As a result of inconvertible transformation of early glycation products, stable compounds with different structure are produced - advanced glycation end-products (AGE), which have special patterns leading to pathological development. There are specific receptors of AGE which include phagocyte receptor, RAGE-receptor for advanced glycation end products, and galectin-3. It is necessary to find methods for prevention of development negative processes induced by glycation. It can be administration of glycation inhibitors or the use of compounds, leading to reduction of the level of glycation products, as well as intensification of metabolic processes, which also promotes reduction of glycation. It can also be inhibition of interlocking with receptor and/or post-receptor signaling pathways, which can theoretically reduce the risk of negative phenomena, induced by glycation products. Polyprenols are biologically highly functional active compounds taking part in the process of polysaccharides, glycoproteins, peptidoglycanes and carbohydrate-containing biopolymers biosynthesis. Polyprenols are perspective drugs that can be applied in various fields of experimental and clinical medicine.

In clinical trials have studied one of the central effects of a selective agonist of V 2 vasopressin receptors, 1-dezamino-8-D-arginine-vasopressin (DDAVP), in patients with Parkinson's disease (PD) and parkinsonism. In patients with a tremor-rigid shape and akinetic-rigid form of the disease regressed major movement disorders: tremor, rigidity, bradykinesia and hypokinesia. These findings point to the new properties vasopressin, enhance understanding of its functional role in humans and its potential use in neurological patients. DDAVP may be used as monotherapy in the early stages of PD and parkinsonism of various origins.