The importance of immunohistochemical examinations for patients with failed IVF-methods

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Abstract


The problem of infertility is one of the most acute in modern reproductive science. The theme of research is poorly conceptualized in modern medical literature and this fact is an additional confirmation of relevance and scientific significance of this theme of research. Due to the use of assisted reproductive technology (art), it became possible the occurrence of pregnancy in infertile marriage. In the article the authors pay significant attention to the role of the endometrium in the implantation process. To better assess the status of the endometrium they apply following studies: hysteroscopy, endometrial biopsy, morphological study of biopsy material, immunohistochemistry. In this article there are features of every method of research and treatment, competitive advantages or disadvantages of them. Having analyzed the results of the immunohistochemical studies, the presence of autoimmune chronic endometritis and chronic endometritis without an autoimmune component was revealed. The result of a comprehensive examination and treatment is an demonstration of statistic information, which shows pregnancy in ninety percent of cases in women with failed IVF attempts in anamnesis. At the same time in sixty percent of cases the pregnancy resulted in the childbirth in terms of 36-40 weeks. During such pregnancies there are only a few specific features: high risks of miscarriage, defects of fetus, extragenital pathology. So, reproductology is very interested in search of new methods, which are able to improve positive results of IVF-methods.


Viktorija N Abramova

Author for correspondence.
grantabramov@mail.ru
St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Russian Federation

gynecologist, Gynecology Department

Sergej N Gajdukov

gaiducovsn@rambler.ru
St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Russian Federation

MD, PhD, Dr Med Sci, Professor, Department of Obstetrics and Gynecology

Anna N Tajc

annataits1@rambler.ru
St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Russian Federation

MD, PhD, Assistant Professor, Department of Obstetrics and Gynecology

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