When is calcium a friend and when is it a foe?

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In the article is described the role of calcium in the human body. Possible consequences of uncontrolled intake of mineral supplements are considered. Possible reasons for their low efficiency in the therapy of bone pathologies are analyzed. The results of a large-scale study are given to answer the question: do calcium-containing drugs reduce the probability of osteoporosis and the risk of fracture? The innovative personalized approach in the therapy of musculoskeletal system diseases, which implies the use of osteoprotectors “Osteomed”, “Osteomed Forte” and “Osteo-Vit D3”, is described.

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作者简介

Villory Strukov

Penza Institute for Advanced Medical Education - a branch of the Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of the Russian Federation

编辑信件的主要联系方式.
Email: villor3737@yandex.ru
ORCID iD: 0000-0003-0959-3933

Doctor of Medical Sciences, Professor, Professor of the Department “Pediatrics”

俄罗斯联邦, 440060, Penza, Stasova str, 8A

Marina Sergeeva-Kondrachenko

Penza Institute for Advanced Medical Education - a branch of the Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of the Russian Federation

Email: marserkon@mail.ru

Doctor of Medical Sciences, Head of the Department “Therapy, General Medical Practice, Endocrinology, Gastroenterology and Nephrology”

俄罗斯联邦, 440060, Penza, Stasova str., 8A

Olga Vinogradova

Penza Institute for Advanced Medical Education - a branch of the Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of the Russian Federation

Email: o_vinogradova69@mail.ru
ORCID iD: 0000-0002-9094-8772

Doctor of Medical Sciences, Head of the Department “Obstetrics and Gynecology”

俄罗斯联邦, 440060, Penza, Stasova str., 8A

Denis Vikhrev

Penza Institute for Advanced Medical Education - a branch of the Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of the Russian Federation

Email: villor3737@yandex.ru

Candidate of Medical Sciences, Director

俄罗斯联邦, 440060, Penza, Stasova str., 8A

Alla Denisova

Penza Institute for Advanced Medical Education - a branch of the Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of the Russian Federation

Email: denisovaag@piuv.ru
ORCID iD: 0000-0002-7453-8335

Doctor of Medical Sciences, Deputy Director for Science and Development, Professor of the Department of Therapy, Cardiology, Functional Diagnostics and Rheumatology

俄罗斯联邦, 440060, Penza, Stasova str., 8A

Elena Panina

Penza State University

Email: panina.es@mail.ru
ORCID iD: 0000-0002-0682-5586

Associate Professor, Department of General and Clinical Pharmacology

俄罗斯联邦, 440026, Penza, Krasnaya St., 40

Inessa Moiseeva

Penza State University

Email: moiseeva_pharm@mail.ru
ORCID iD: 0000-0003-1168-2871

Doctor of Medical Sciences, Professor, Head of the Department of General and Clinical Pharmacology

俄罗斯联邦, 440026, Penza, Krasnaya St., 40

Elena Petrova

Penza State University

Email: petrovaelena2010@yandex.ru
ORCID iD: 0000-0002-5941-8300

Candidate of Medical Sciences, associate professor, head of department “Neurology, neurosurgery and psychiatry”

俄罗斯联邦, 440026, Penza, Krasnaya St., 40

Pavel Poluboyarinov

Penza State University

Email: poluboyarinovpavel@yandex.ru
ORCID iD: 0000-0001-9870-0272

Candidate of Agricultural Sciences, Associate Professor, Associate Professor of General and Clinical Pharmacology Department

俄罗斯联邦, 440026, Penza, Krasnaya St., 40

Alexander Fedorov

Penza State Agrarian University

Email: villor3737@yandex.ru

agronomist

俄罗斯联邦, 440014, Penza, Botanicheskaya St., 30

Gor Brudyan

Voskresensk Dental Polyclinic

Email: dr-brudyan@mail.ru
ORCID iD: 0009-0009-9434-8537

surgeon

俄罗斯联邦, 140209, Moscow Region, Voskresensk, ul. Zapadnaya, 14

参考

  1. Gromova O. A., Kudrin A. V. Neurochemistry of macro- and microelements. New approaches to pharmacotherapy. M.: Alev-V, 2001. 272 с.
  2. Studenikin V. M., Kurbaitaeva E.M. Calciopenic conditions and their correction. Treating Physician. 2010; 10: 54–56.
  3. Parekh A. B., Putney J. W. Store-Operated Calcium Channels. Physiol Rew. 2005; 85: 757–810.
  4. Strukov V. I. Hypervitaminosis D and hypercalcemic states. When is calcium dangerous? monograph. Penza: State Budgetary Educational Institution of Higher Professional Education of the Ministry of Health of Russia, 2014. 194 с.
  5. Li K., Kaaks R., Linseisen J. et.al. Associations of dietary calcium intake and calcium supplementation with myocardial infarction and stroke risk and overall cardiovascular mortality in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition study (EPIC-Heidelberg). Heart. 2012; 98: 920–925.
  6. Bolland M. J., Avenell A., Baron J. A. et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: a meta-analysis. BMJ. 2010; 341: c3691.
  7. Patel A. M., Goldfarb S. Got calcium? Welcome to the calcium-alkali syndrome. J. Am. Soc. Nephrol. 2010; 21(9): 1440–1443.
  8. Gao X., LaValley M. P., Tucker K. L. Prospective studies of dairy products and calcium intakes and prostate cancer risk: a meta-analysis. J. Natl. Cancer. Inst. 2005; 97(23): 1768–1777.
  9. Tai V., Leung W., Grey A. et al. Calcium intake and bone mineral density: systematic review and meta-analysis. BMJ. 2015; 351: h4183.
  10. Bolland M. J., Leung W., Tai V. et al. Calcium intake and risk of fracture: a systematic review. BMJ. 2015; 351: h4580.
  11. Strukov V. I., Kislov A. I., Eremina N. V. et.al. The use of bone tissue non-steroid anabolizators in treatment of osteoporosis. Research Journal of Pharmacy and Technology. 2019; 12(5): 2195–2199.
  12. Strukov V.I., Elistratov D.G., Vikhrev D.V., et al. Personalized approach to diagnosis and therapy of comorbid osteoporosis in clinical practice. Vrach. 2022; 33(6): 20–25.

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2. Pic. 1. The process of bone mineralization

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3. Pic. 2. Changes in testosterone synthesis with age

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4. Pic. 3. Degenerative changes in the joints

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