Тhe positive role of obesity

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Abstract

The well-established notion that obese patients are the leading factor in the development of a significant number of somatic diseases and related problems is well known. It is logical to expect a severe course of diseases and unfavourable general medical prognosis in obese people, but in recent years, sensational scientific publications have appeared that refute the established opinion of clinicians and pathophysiologists about the unambiguously unfavourable effect of obesity on human health. This strange fact has been called the “obesity paradox” and is considered an epidemiological discovery.

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About the authors

Lydia P. Khoroshinina

Federal State Budgetary Educational Institution of Higher Education «St. Petersburg State Pediatric Medical University» of the Ministry of Health of the Russian Federation

Author for correspondence.
Email: spb@gpmu.org
ORCID iD: 0000-0002-4930-1424

Doctor of Medical Sciences, Professor, Professor V.A. Waldman Department of Faculty Therapy

Russian Federation, St. Petersburg

Elena S. Ivanyuk

Physicians Military Medical Academy named after S.M. Kirov MO RF

Email: solt54@mail.ru
ORCID iD: 0000-0002-2785-6699

Candidate of Medical Sciences, doctor gastroenterologist, Associate Professor of the 2nd Department of Advanced Medical Training of Physicians

Russian Federation, St. Petersburg

References

  1. Flegal K.M., Kit B.K., Orpana H. et al. Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA. 2013; 309 (1): 71–82.
  2. Jackson R.S., Black 3rd J.H., Lum Y.W. et al. Class I obesity is paradoxically associated with decreased risk of postoperative stroke after carotid endarterectomy. J. Vasc. Surg. 2012; 55 (5): 1306–1312.
  3. Barry V.W., Baruth M., Beets M.W. et. al. Fitness vs. fatness on all-cause mortality: a meta-analysis. Prog Cardiovasc Dis Jan-Feb 2014; 56 (4): 382–390.
  4. Veronese N., Cereda E., Solmi M. et al. Inverse relationship between body mass index and mortality in older nursing home residents: a meta-analysis of 19,538 elderly subjects. Obes. Rev. 2015; 16 (11): 1001–1015.
  5. Lavie C.J., Schutter A., Archer E. et.al. Obesity and prognosis in chronic diseases--impact of cardiorespiratory fitness in the obesity paradox. Curr. Sports Med. Rep. Jul-Aug. Jul-Aug 2014; 13 (4): 240–245.
  6. McAuley P.A, Artero E.G., Sui X. et al. The obesity paradox, cardiorespiratory fitness, and coronary heart disease. The obesity paradox, cardiorespiratory fitness, and coronary heart disease. Mayo Clin. Proc. 2012; 87 (5): 443–451.
  7. Lavie C.J., Schutter A., Parto P. et. al. Obesity and Prevalence of Cardiovascular Diseases and Prognosis-The Obesity Paradox Updated. Prog Cardiovasc Dis Mar-Apr 2016; 58 (5): 537–547.
  8. Carbone S., Lavie C.J., Arena R. Obesity and Heart Failure: Focus on the Obesity Paradox. Mayo Clin Proc. 2017; 92 (2): 266–279.
  9. Lavie C.J., Sharma A., Alpert M.A. et al. Ventura Update on Obesity and Obesity Paradox in Heart Failure. Prog Cardiovasc.
  10. Shah R., Gayat E., Januzzi J.L. et al. GREAT (Global Research on Acute Conditions Team) Network Body mass index and mortality in acutely decompensated heart failure across the world: a global obesity paradox. J. Am. Coll. Cardiol. 2014; 63 (8): 778–785.
  11. Chase P.J., Davis P.G., Bensimhon D.R. The obesity paradox in chronic heart failure: what does it mean? Curr. Heart. Fail. Rep. 2014; 11 (1): 111–117.
  12. Lavie C.J., Alpert M.A., Arena R. et al. Impact of obesity and the obesity paradox on prevalence and prognosis in heart failure. JACC. Heart Fail. 2013; 1 (2): 93–102.
  13. Vest A.R., Wu Y., Hachamovitch R. et al. The Heart Failure Overweight/Obesity Survival Paradox: The Missing Sex Link. JACC Heart Fail. 2015; 3 (11): 917–926.
  14. Apurva O., Badheka, Rathod A., Mohammad A. et al. Influence of obesity on outcomes in atrial fibrillation: yet another obesity paradox. Am J Med, 2010; 123 (7): 646–651.
  15. Лебедев П.А., Вербовой А.Ф., Матееску К.А. и др. Парадокс ожирения и постинфарктное ремоделирование у пациентов с Q-инфарктом миокарда. Кардиология: новости, мнения, обучение, 2018: 18 (3): 74–82. [Lebedev P.A., Verbovoy A.F., Mateescu C.A. et al. The obesity paradox and postinfarction remodelling in patients with myocardial Q-infarction. Cardiology: news, views, learning, 2018: 18 (3): 74–82.]
  16. Sakr Y., Elia C., Mascia L. et al. Being overweight or obese is associated with decreased mortality in critically ill patients: a retrospective analysis of a large regional Italian multicenter cohort. J. Crit. Care. 2012; 27 (6): 714–721.
  17. Baumgartner R. et.al. Obesity Paradox and Stroke. Praxis (Bern 1994). 2016; 105 (14): 835–841.
  18. France Anne Victoire Pirson H Hinsenveld, Julie Staals et al. Effect of Body Mass Index on Outcome after Endovascular Treatment in Acute Ischemic Stroke Patients: A Post Hoc Analysis of the MR CLEAN Trial. Cerebrovasc Dis. 2019; 48 (3–6): 200–206.
  19. Jackson R.S., Black J.H. 3rd, Lum Y.W. et al. Class I obesity is paradoxically associated with decreased risk of postoperative stroke after carotid endarterectomy. J. Vasc. Surg. 2012; 55 (5): 1306–1312.
  20. Mullen J.T., Moorman D.W., Davenport D.L. The obesity paradox: body mass index and outcomes in patients undergoing nonbariatric general surgery. Ann Surg. 2009; 250 (1): 166–172.
  21. Ludhwani D., Wu J. Obesity Paradox in Peripheral Arterial Disease: Results of a Propensity Match Analysis from the National Inpatient Sample. Cureus. 2019; 11 (5): e4704.
  22. Batsis J.A., Huddleston J.M., Melton L.J. et al. Body mass index (BMI) and risk of noncardiac postoperative medical complications in elderly hip fracture patients: a population-based study. J. Hosp. Med. 2009; 4 (8): E1–9.
  23. Zhang J.C., Matelski J., Gandhi R. et al. Patient Selection Explain the Obesity Paradox in Orthopaedic Hip Surgery? An Analysis of the ACS-NSQIP Registry. Clin. Orthop. Relat Res. 2018; 476 (5): 964–973.
  24. Shaparin N., Widyn J., Nair S. et al. Does the obesity paradox apply to early postoperative complications after hip surgery? A retrospective chart review J. Clin. Anesth. 2016; (32): 84–89.
  25. Gaulton T.G., MacNabb C.M. et al. A retrospective cohort study examining the association between body mass index and mortality in severe sepsis. Intern. Emerg. Med. 2015; 10 (4): 471–479.
  26. Guo L., Li N., Wang G. et al. Body mass index and cancer incidence:a prospective cohort study in northern China Zhonghua Liu Xing Bing Xue Za Zhi. 2014; 35 (3): 231–236.
  27. Gupta A., Majumder K., Arora N. et al. Premorbid body mass index and mortality in patients with lung cancer: A systematic review and meta-analysis. Lung. Cancer. 2016; (102): 49–59.
  28. Xie S.H. et al. Association between body mass index and risk of lung cancer in non-smoking males: a prospective cohort study. Article in Chinese. 2016; 37 (9): 1213–1219.
  29. Zamora E., Diez-Lоpez C., Lupin J. et al. Weight Loss in Obese Patients with Heart Failure. J. Am. Heart. Assoc. 2016; 5 (3): e002468.
  30. Niedziela J.T., Hudzik B., Strojek K. et al. Weight loss in heart failure is associated with increased mortality only in non-obese patients without diabetes. J. Cachexia Sarcopenia Muscle. 2019; 10 (6): 1307–1315.
  31. Vecchi A., Dallegri F., Carbone F. et аl. Obesity phenotypes and their paradoxical association with cardiovascular diseases. Eur J Intern Med. 2018; (48): 6–17.
  32. Elagizi A., Kachur S., Lavie C.J. et al. An Overview and Update on Obesity and the Obesity Paradox in Cardiovascular Diseases. Prog Cardiovasc Dis Jul-Aug 2018; 61 (2): 142–150.

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