Morphological and functional changes in the thyroid gland in patients with amiodarone-induced hypothyroidism
- Authors: Chernavsky S.V.1,2, Davydov D.V.1,3, Borisov A.G.1,2, Stremoukhov A.A.4, Dorokhina A.V.1, Artyushkevich O.V.1, Kudentsova L.A.1
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Affiliations:
- The N.N.Burdenko Main Military Clinical Hospital of the Ministry of Defense of the Russian Federation
- Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation
- Peoples’ Friendship University of Russia
- 2Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation
- Issue: Vol 343, No 7 (2022)
- Pages: 52-54
- Section: Brief articles
- URL: https://journals.eco-vector.com/0026-9050/article/view/629952
- DOI: https://doi.org/10.52424/00269050_2022_343_7_52
- ID: 629952
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Abstract
Amiodarone is the drug of choice to treat most types of arrhythmias. Taking the drug sometimes has a significant effect on the function of the thyroid gland, causing the development of amiodarone-induced thyroid disorders, including hypothyroidism. According to the study, amiodarone-induced hypothyroidism developed in 26.1% of all thyroid disorders within 14.2±1.5 months from the start of the drug. Most often, it was diagnosed with overweight individuals who received intravenous administration of the drug over 2 times a year, with a long history of thyroid disease.
About the authors
S. V. Chernavsky
The N.N.Burdenko Main Military Clinical Hospital of the Ministry of Defense of the Russian Federation; Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation
Author for correspondence.
Email: chernavskijsv@mail.ru
Russian Federation, Moscow; Moscow
D. V. Davydov
The N.N.Burdenko Main Military Clinical Hospital of the Ministry of Defense of the Russian Federation; Peoples’ Friendship University of Russia
Email: chernavskijsv@mail.ru
Russian Federation, Moscow; Moscow
A. G. Borisov
The N.N.Burdenko Main Military Clinical Hospital of the Ministry of Defense of the Russian Federation; Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation
Email: chernavskijsv@mail.ru
Russian Federation, Moscow; Moscow
A. A. Stremoukhov
2Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation
Email: chernavskijsv@mail.ru
Russian Federation, Moscow
A. V. Dorokhina
The N.N.Burdenko Main Military Clinical Hospital of the Ministry of Defense of the Russian Federation
Email: chernavskijsv@mail.ru
Russian Federation, Moscow
O. V. Artyushkevich
The N.N.Burdenko Main Military Clinical Hospital of the Ministry of Defense of the Russian Federation
Email: chernavskijsv@mail.ru
Russian Federation, Moscow
L. A. Kudentsova
The N.N.Burdenko Main Military Clinical Hospital of the Ministry of Defense of the Russian Federation
Email: chernavskijsv@mail.ru
Russian Federation, Moscow
References
- Адашева Т.В., Демичева О.Ю. Кордарон и тиреоидная патология. Мифы и реальность // Мед. вестн. – 2013. – № 17. – С. 12–13.
- Голицын С.П. Амиодарон десятилетия спустя // Тер. арх. – 2011. – Т. 83, № 8. – С. 25–33.
- Гринева Е.Н., Цой У.А., Каронова Т.Л. и др. Проект федеральных клинических рекомендаций по диагностике и лечению амиодарониндуцированной дисфункции щитовидной железы // Клин. и эксперимент. тиреоидология. – 2020. – Т. 16, № 20. – С. 12–24.
- Крюков Е.В., Потехин Н.П., Фурсов А.Н. и др. Алгоритм ведения пациентов, получающих амиодарон, в зависимости от функционального состояния щитовидной железы // Клин. медицина. – 2017. – Т. 95, № 10. – С. 901–904.
- Фадеев В.В. Современные концепции диагностики и лечения гипотиреоза у взрослых // Пробл. эндокринол. – 2004. – № 2. – С. 47–55.
- Igonin V.A., Proskurin M.V., Serebrennikov V.N. Amiodarone-associated thyrotoxicosis: the complexity of diagnosis and treatment // Klinicheskaya tireoidologiya. – 2004. – Vol. 2, N 4. – P. 53–55.
- Klein I., Ojamaa K. Thyroid hormone and the cardiovascular system // N. Engl. J. Med. – 2001. – Vol. 344, N 7. – P. 501–509.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).