Vaccination of viral infections: history and current problems
- Authors: Moskalev A.V.1, Gumilevsky B.Y.1, Zhogolev K.D.1
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Affiliations:
- The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation
- Issue: Vol 345, No 5 (2024)
- Pages: 61-72
- Section: Epidemiology and infectious diseases
- URL: https://journals.eco-vector.com/0026-9050/article/view/631495
- DOI: https://doi.org/10.52424/00269050_2024_345_5_61
- ID: 631495
Cite item
Abstract
The article reflects the historical evolution of approaches to solving the problem of vaccinal prevention of viral infections. The effectiveness of modern vaccine prophylaxis is associated with advances in biotechnology, immunization with attenuated viruses, purified viral proteins, specific antibodies, and activated T-lymphocytes. The success of vaccination depends on the formation of collective immunity. Immunization should cause the same type of immune response as the infection. The effectiveness of vaccination is affected by options for the introduction of vaccines, violations of the «cold chain», the age and health of the vaccinated. Prospects for vaccination are associated with new options for obtaining subunit vaccines, vaccines based on nucleic acids. They are characterized by rapid development, low-cost and safe production, and effective activation of cellular and humoral immunity. Increasing the effectiveness of vaccine prevention of viral infections will also be associated with further study of the biology of viruses and the immunopathogenesis of viral infections, taking into account the individual immune response.
Keywords
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About the authors
A. V. Moskalev
The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation
Author for correspondence.
Email: vmeda_na@mail.ru
заслуженный работник высшей школы РФ, профессор, полковник медицинской службы в отставке
Russian Federation, St. PetersburgB. Yu. Gumilevsky
The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation
Email: vmeda_na@mail.ru
профессор
Russian Federation, St. PetersburgK. D. Zhogolev
The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation
Email: vmeda_na@mail.ru
доктор медицинских наук, доцент, полковник медицинской службы в отставке
Russian Federation, St. PetersburgReferences
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