Does desflurane have advantages in comparison with sevoflurane at the planned intracranial interventions

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The aim of the study was to compare the effect of sevoflurane and desflurane on the rate of patient awakening from anaesthesia, recovery of orientation, memory and concentration, and the incidence of side effects after elective surgery on the brain. The study included 42 patients, divided into two equal groups. In the first as the main anaesthetic used sevoflurane, in the second - desflurane. Wake-up time, and extubation of recovery of consciousness after desfluranom was less than when using sevoflurane as a anesthetic by 185, 301 and 296, respectively. Time needed for orientation, memory and concentration recovery varied in 15 and 30 minutes (in the desflurane group were faster) after waking up with full recovery in the preoperative level after 2 hours. Using desflurane was not accompanied by deterioration in the operations environment and does not lead to an increase in the number of adverse postoperative phenomena.

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  1. Близнов А.А., Заварзин А.Ю., Унту Ф.И., Стец В.В. Наш опыт клинического использования десфлурана // Воен.-мед. журн. - 2014. - Т. 335, № 12. - С. 29-32.
  2. Лихванцев В.В., Мироненко А.В., Габитов М.В., Скрипкин Ю.В., Гребенчиков О.А., Михайлов Д.А. Клиническая значимость различий в скорости посленаркозного восстановления после операций, выполненных в условиях современных вариантов общей анестезии // Вестн. анестезиол. реаниматол. - 2014. - Т. 11, № 3. - С. 3-9.
  3. Bruder N., Ravussin P. Recovery from anesthesia and postoperative extubation of neurosurgical patients: a review // J. Neurosurg. Anesthesiol. - 1999. - Vol. 11, N 4. - P. 282-293.
  4. Dinsmore J. Anaesthesia for elective neurosurgery // British J. of Anaesth. - 2007. - Vol. 99. - P. 68-74.
  5. Duffy C.M., Matta B.F. Sevoflurane and anesthesia for neurosurgery: A review // J. Neurosurg. Anesthesiol. - 2000. - Vol. 12, N 2. - P. 128-140.
  6. Eger E.I. II, Bowland T., Ionescu P., Laster M.J., Fang Z., Gong D. et al. Recovery and kinetic characteristics of desflurane and sevoflurane in volunteers after 8-h exposure, including kinetics of degradation products // Anesthesiol. - 1997. - Vol. 87. - P. 517-526.
  7. Eger E.I. II, Gong D., Koblin D.D., Bowland T., Ionescu P., Laster M.J. et al. Effect of anesthetic duration on kinetic and recovery characteristics of desflurane vs. sevoflurane (plus compound A) in volunteers // Anesth. Analg. - 1998. - Vol. 86. - P. 414-421.
  8. Fraga M., Rama-Maceiras P., Rodino S., Aymerich H., Pose P. The effects of isoflurane and desflurane on intracranial pressure, cerebral perfusion pressure and cerebral arteriovenous oxygen content difference in normocapnic patients with supratentorial brain tumors // Anesthesiol. - 2003. - Vol. 98. - P. 1085-1090.
  9. Holmstrom A., Akeson J. Desflurane increases intracranial pressure more and sevoflurane less than isoflurane in pigs subjected to intracranial hypertension // J. Neurosurg. Anesthesiol. - 2004. - Vol. 16. - P. 136-143.
  10. Magni G., La Rosa I., Gimignani S., Melillo G., Imperiale C., Rosa G. Early postoperative complications after intracranial surgery: comparison between total intravenous and balanced anesthesia // J. Neurosurg. Anesthesiol. - 2007. - Vol. 19, N 4. - P. 229-234.
  11. Manninen P.H., Raman S.K., Boyle K., el-Beheiry H. Early postoperative complications following neurosurgical procedures // Can. J. Anaesth. - 1999. - Vol. 46, N 1. - P. 7-14.
  12. Muzzi D.A., Losazzo T.J., Dietz N.M., Faust R.J., Cucchiara R.F., Milde L.N. The effect of desflurane and isoflurane on cerebrospinal fluid in humans with supratentorial mass lesions // Anesthesiol. -1992. - Vol. 76, N 720. - P. 4.
  13. Rhondali O., Genty C., Halle C., Gardellin M., Ollinet C., Oddoux M. et al.Do patients still require admission to an intensive care unit after elective craniotomy for brain surgery // J. Neurosurg. Anesthesiol. - 2011. - Vol. 23, N 2. - P. 118-123.
  14. Zuleta-Alarcуn A., Castellуn-Larios K., Niсo-de Mejнa M.C., Bergese S.D. Total intravenous anaesthesia versus inhaled anaesthetics in neurosurgery // Colombian J. of Anesthesiol. - 2015. - Vol. 43. - P. 9-14.

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