Pharmacological tolerance to medical therapy of organophosphate poisoning and ways of tolerance management


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

Authors consider causes of low efficiency of antidote therapy and ways of pharmacological tolerance management during medical treatment of organophosphate poisoning. One of the promising ways is a preventive antidote on the base of enzyme agents and allosteric modulators of a cholinesterase activity. Authors showed a expediency of a study of new acetylcholinesterase reactivators, its compositions and ways of drug delivery. Authors specified ways of searching for anticonvulsants from classes of quick-closing benzodiazines and NMDA-antagonists. Authors defined ways of improvement of methods of special antidotes delivery with targeted transport system. Authors made an assumption about the necessity of symptomatic treatment.

Full Text

Restricted Access

References

  1. Юдин М.А., Иванов И.М., Никифоров А.С. и др. Применение комплекса включения циклодекстрин-амбеноний для повышения эффективности терапии отравлений антихолинэстеразными соединениями // Бюл. эксперим. биологии и медицины. - 2013. - Т. 155, № 2. - С. 184-187.
  2. Юдин М.А., Субботина С.Н., Быков В.Н. и др. Перспективы применения бензодиазепинов в комплексной терапии отравлений антихолинэстеразными соединениями// Бюл. эксперим. биологии и медицины. - 2013. - Т. 155, № 2. - С. 331-336.
  3. Юдин М.А., Субботина С.Н., Кузьмин А.А. и др. К вопросу о применении NMDA-литических средств в схемах терапии органофосфатиндуцированного судорожного синдрома // Биомед. журн. Medline.ru. - 2012. - Т. 13. - С. 583-596.
  4. Юдин М.А., Чепур С.В., Быков В.Н. и др. Особенности противосудорожной активности мемантина при отравлении модельным органофосфатом // Эксперим. и клин. фармакология. - 2013. - Т. 76, № 2. - С. 3-5.
  5. Balali-Mood M.K., Hosseini Shirazi F. Recent advances in treatment of acute organophosphorous nerve agents poisoning // Iranian J. of pharmaceutical research. - 2006. - N 2. - P. 79-87.
  6. Demar J.C., Clarkson E.D., Ratcliffe R.H. et al. Pro-2-PAM therapy for central and peripheral cholinesterases // Chem. Biol. Interact. - 2010. - Vol. 187, N 1-3. - P. 191-198.
  7. Gilat E, Goldman M., Lahat E. et al. Nasal midazolam as a novel anticonvulsive treatment against organophosphate-induced seizure activity in the guinea pig // Arch. Toxicol. - 2003. - Vol. 77. - P. 167-172.
  8. Herkert N.M., Aurbek N, Eyer P. et al. Comparative study of oxime-induced reactivation of erythrocyte and muscle AChE from different animal species following inhibition by sarin or paraoxon // Toxicol. Lett. - 2010. - Vol. 194, N 3. - P. 94-101.
  9. Kassa J, Karasova J.Z, Pavlikova R. et al. The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of tabun poisoning in rats and mice // J. Appl. Toxicol. - 2010. - Vol. 30, N 2. - P. 120-124.
  10. Khan W.A., Dechkovskaia A.M., Herrick EA. et al. Acute sarin exposure causes differential regulation of choline acetyltransferase, acetylcholinesterase, and acetylcholine receptors in the central nervous system of the rat // Toxicol. Sci. - 2000. - Vol. 57, N 1. - P. 112-120.
  11. Kuca K., Musilek K., Jun D. et al. Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase // J. Enzyme Inhib. Med. Chem. - 2010. - Vol. 25, N 4. - P. 509-512.
  12. Luo C., Ashani Y., Bhupendra P. Acceleration of oxime-induced reactivation of organophosphate-inhibited fetal bovine serum acetylcholinesterase by monoquaternary and bisquaternary ligands // Mol. pharmacology. - 1998. - Vol. 53. - P. 718-726.
  13. Maxwell D.M., Saxena A., Gordon R.K. et al. Improvements in scavenger protection against organophosphorus agents by modification of cholinesterases // Chem. Biol. Interact, - 1999. - Vol. 14. - P. 419-428.
  14. Musilek K., Dolezal M., Gunn-Moore F. et al. Design, evaluation and structure-аctivity relationship studies of the AChE reactivators against organophosphorus pesticides // Med. Res. Rev. - 2009. - Vol. 17. - P. 76-79.
  15. Patent US 5939095.URL: www.google. ru/patents/US5939095 (дата обращения: 19.04.2014).
  16. Patent US 20060099200. URL: www. google.com/patents/US20060099200 (дата обращения: 19.04.2014).
  17. Patent US 20060216241. URL: www. google.com/patents/US20060216241 (дата обращения: 19.04.2014).
  18. Patent US 20070048229. URL: www. google.com/patents/US20070048229 (дата обращения: 19.04.2014).
  19. Patent US 20090176802. URL: www. google.com/patents/US20090176802 (дата обращения: 19.04.2014).
  20. Radi Z, Kalisiak J., Fokin V.V. et al. Interaction kinetics of oximes with native, phosphylated and aged human acetylcholinesterase // Chem. Biol. Interact. - 2010. - Vol. 187, N 1-3. - P. 163-166.
  21. Weissman B.A., Raveh L. Therapy against organophosphate poisoning: the importance of anticholinergic drugs with antiglutamatergic properties // Toxicol. appl. harmacol. - 2008. - Vol. 232, N 2. - P. 351-358.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2014 Yudin M.A., Bykov V.N., Chepur S.V., Sarana A.M., Tsygan V.N., Anokhin A.G.


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: № 01975 от 30.12.1992.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies