Modern condition and prospects of improvement of the specialized medical aid of acute marrow failure of radiant etiology



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Abstract

It is shown, that tactics of treatment of acute marrow failure of radiant etiology is based, first of all, on measures of supporting, replaceable and stimulating therapy. The modern means, used for prophylactic and treatment of infectious complications, are resulted. Opportunities and restrictions of transfusion of donor thrombocytes and granulocytes, erythrocytes and chilled plasma are described. Therapeutic efficiency of transplantation of a bone marrow,cells of embryonic liver and stem cells of peripheral or umbilical cord blood is analyzed. It is shown, that the greatest prospects in perfection of the specialized medical aid at acute radiation syndrome are connected to complex application of interleukin-1в·, interleukin-3, granulocyte or granulocyte/macrophage colony stimulated factor, thrombopoietin and others cytokines.

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  1. Аветисов Г.М., Владимиров В.Г., Гончаров С.Ф. и др. Синдромы острой лучевой болезни: клинические проявления, профилактика и лечение. — М.: ВЦМК «Защита», 2003. — 244 с.
  2. Аклеев А.В. Модификация радиационных иммунных ответов // Радиац. биол. Радиоэкол. - 2009. - Т. 49, № 5. - С. 517-527.
  3. Баранов А.Е., Рождественский Л.М. Аналитический обзор схем лечения острой лучевой болезни, используемых в эксперименте и клинике // Радиац. биол. Радиоэкол. - 2008. - Т. 8, № 3. - С. 287-302.
  4. Бутомо Н.В., Гребенюк А.Н., Легеза В.И. и др.; Основы медицинской радиобиологии / Под ред. И.Б.Ушакова. - СПб: Фолиант, 2004. - 384 с.
  5. Гребенюк А.Н., Смирнов Н.А., Севрук Ю.А., Тимошевский А.А. Перспективные направления фармакологической коррекции пострадиационных нарушений иммунитета // Воен.-мед. журн. - 2006. - Т. 327, № 8. - С. 49-53.
  6. Кетлинский С.А., Симбирцев А.С. Цитокины. - СПб: Фолиант, 2008. - 552 с.
  7. Легеза В.И., Попов А.В., Салухов В.В., Турлаков Ю.С. Гранулоцитарный колониестимулирующий фактор лейкостим - средство патогенетической терапии постлучевого костномозгового синдрома // Вестн. рос. воен.-мед. акад. - 2010. - № 2 (30). - С. 135-139.
  8. Радиационная медицина: Руководство для врачей-исследователей и организаторов здравоохранения. T. II. Радиационные поражения человека // Под ред. Л.А.Ильина. -М.: ИздАТ, 2001. - 432 с.
  9. Рождественский Л.М. Интерлейкин-1 - центральный провоспалительный цитокин плейотропного действия в эксперименте и клинике // Мед. радиол. и радиац. безопасность. - 2001. - Т. 6, № 4. - С. 5-11.
  10. Селидовкин Г.Д. Современные методы лечения больных острой лучевой болезнью в специализированном стационаре (аналитический обзор) // Медицина катастроф. - 1995. - № 1-2 (9-10). - С. 135-149.
  11. Симбирцев А.С. Интерлейкин-1: Физиология. Патология. Клиника. - СПб: Фолиант, 2011. - 480 с.
  12. Халимов Ю.Ш., Гребенюк А.Н., Карамуллин М.А. и др. Современные возможности оказания терапевтической помощи при возникновении массовых санитарных потерь радиационного профиля // Воен.-мед. журн. - 2012. - Т. 333, № 2. - С. 24-32.
  13. Asai T., Inaba S, Ohto H. et al. Guidelines for irradiation of blood and blood components to prevent post-transfusion graft-vs.-host disease in Japan // Transfus. Med. - 2000. - Vol. 10, N 4. - P. 315-320.
  14. Baranov A., Gale R.P., Guskova A. et al. Bone marrow transplantation after the Chernobyl nuclear accident // N. Engl. J. Med. - 1989. -Vol. 321. - P. 205-212.
  15. Dainiak N. Rationale and recommendations for treatment of radiation injury with cytokines // Health Phys. - 2010. - Vol. 98, N 6. -P. 838-842.
  16. Dainiak N., Ricks R.C. The evolving role of haematopoietic cell transplantation in radiation injury: potentials and limitations // Br. J. Radiol. - 2005. - Vol. 27, suppl. - P. 169-174.
  17. Drouet M., Delaunay C., Grenier N. et al. Cytokines in combination to treat radiation-induced myelosuppression: evaluation of SCF + glycosylated EPO + pegylated G-CSF as an emergency treatment in highly irradiated monkeys // Haematologica. - 2008. - Vol. 93. - P. 465466.
  18. Drouet M., Hrnodin F. Radiation victim management and the haematologist in the future: time to revisit therapeutic guidelines? // Int. J. Radiat. Biol. - 2010. - Vol. 86. - P. 636-648.
  19. Engelfriet C.P., Reesink H.W. Use of cord blood progenitor cells as an alternative for bone marrow transplantation // Vox Sang. - 1998. -Vol. 75. - P. 156-172.
  20. Fliedner T.M. Blood stem cell transplantation: from preclinical to clinical models // Stem Cells. - 1995. - Vol. 13. - P. 1-12.
  21. Fliedner T.M., Friesecke I., Beyrer K. et al. Medical management of radiation accidents: Manual on the acute radiation syndrome (METREPOL). - Oxford: The British Institute of Radiology, 2001. - 66 p.
  22. Fliedner T.M., Graessle D., Meineke V., Dorr H. Pathophysiological principles underlying the blood cell concentration responses used to assess the severity of effect after accidental whole-body radiation exposure: an essential basis for an evidence-based clinical triage // Exp. Hematol. - 2007. - Vol. 35, N 4. - suppl. 1. - P. 8-16.
  23. Herodin F., Bourin P., Mayol J.-F. et al. Short-term injection of antiapoptotic cytokine combinations soon after lethal г-irradiation promotes survival // Blood. - 2003. - Vol. 101, N 7. - P. 2609-2615.
  24. Hirama T., Tanosaki S., Kandatsu S. et al. Initial medical management of patients severely irradiated in the Tokai-mura criticality accident // Br. J. Radiol. - 2003. - Vol. 76. - P. 246-253.
  25. Koenig K.L., Goans R.E., Hatchett R.J. et al. Medical treatment of radiological casualties: current concepts // Ann. Emergency Med. - 2005. - Vol. 45. - P. 643-652.
  26. Korbling M., Huh Y.O., Durett A. et al. Allogeneic blood stem cell transplantation: peripheralization and yield of donor-derived primitive hematopoietic progenitor cells (CD34+ Thy-1 dim) and lymphoid subsets, and possible predictors of engraftment and graft-versus-host disease // Blood. - 1995. - Vol. 86. - P. 2842-2848.
  27. McVittie T.J., Fareze A.M., Smith W.G. et al. Myelopoietin, an engieneered chhimeric IL-3 and G-CSF receptor agonist, stimulates multilineage hematopoietic recovery in a nonhuman primate model of radiation-induced myelosuppression // Blood. - 2000. - Vol. 95, N 3. - P. 837-844.
  28. Neelis K.J., Dubbelman Y.D., Qingliang L. et al. Simultaneous administration of TPO and G-CSF after cytoreductive treatment of rhesus monkeys prevents thrombocytopenia, accelerates platelet and red cell reconstitution, alleviates neutropenia, and promotes the recovery of immature bone marrow cells // Exp. Hematol. -1997. - Vol. 25. - P. 1084-1093.
  29. Neelis K.J., Hartong S.C., Egeland T. et al. The efficacy of single dose administration of thrombopoietin with coadministration of either granulocyte/macrophage or granulocyte colony stimulated factor in myelosuppressed rhesus monkeys // Blood. - 1997. - Vol. 90, N 7. -P. 2565-2573.
  30. Smith T.J., Khatcheressian J., Lyman G.H. et al. 2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline // J. Clin. Oncol. - 2006. - Vol. 24, N 19. - P. 3187-3205.
  31. Triage, Monitoring and Treatment of people exposed to ionizing radiation following a malevolent act (TMT Handbook) / Eds. by C.Rojas-Palma, A.Liland, A.Nass Jerstad et al. -Lobo Media AS, Norway, 2009. - 560 p.
  32. Wagemaker G., Neelis K.J., Hartong S. et al. The efficacy of recombinant thrombopoietin in murine and nonhuman primate models for radiation-induced myelosuppression and stem-cell transplantation // Stem Cells. - 1998. - Vol. 16, suppl. 2. - P. 127-141.
  33. Waselenko J.K., McVittie T.J., Blakely W.F. еt al. Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group // Ann. Intern. Med. - 2004. - Vol. 140, N 12. -P. 1037-1051.

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