Effectiveness of pelvic lymphadenectomy in the treatment of prostate cancer



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Abstract

The results of extended pelvic lymphadenectomy for radical prostatectomy performed in 157 patients with localized and locally advanced prostate cancer from 2012 to 2017 are analyzed. In addition to the treatment-and-prophylactic effect, lymphadenectomy and prostate cancer determine the need for adjuvant treatment. The frequency of metastases and their localization were assessed, the risk of complications when performing advanced pelvic lymphadenectomy was analyzed. Lymph node metastases were diagnosed in 22 (14%) patients, a total of 42 affected nodes were removed. According to N + localization, 14 (33.3%) were detected along the external iliac vessels, 19 (45.3%) in the internal iliac vessels, and 9 (21.4%) in the locking fossa of the lymph nodes. Thus, metastasis of prostate cancer was most often (45.3%) diagnosed in the internal ileal lymph nodes.

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About the authors

S. P Shershnev

PKU "Central military clinical hospital named after P. V. Mandryka" MO RF

Email: info@2cvkg.ru
Moscow

O. L Reinyuk

PKU "Central military clinical hospital named after P. V. Mandryka" MO RF

Moscow

A. V Savilov

PKU "Central military clinical hospital named after P. V. Mandryka" MO RF

Moscow

A. N Levkovskii

PKU "Central military clinical hospital named after P. V. Mandryka" MO RF

Moscow

P. E Krainyukov

PKU "Central military clinical hospital named after P. V. Mandryka" MO RF

Moscow

V. I Babskii

PKU "Central military clinical hospital named after P. V. Mandryka" MO RF

Moscow

M. A Makanin

PKU "Central military clinical hospital named after P. V. Mandryka" MO RF

Moscow

References

  1. Алексеев Б.Я., Нюшко К.М., Воробьев Н.В. Частота и локализация метастазов в лимфатических узлах при выполнении радикальной простатэктомии и расширенной тазовой лимфаденэктомии у больных раком предстательной железы // Онкоурология. - 2012. - № 1. - С. 77-81.
  2. Коган М.И., Лоран О.Б., Петров С.Б. Радикальная хирургия рака предстательной железы. - М. ГЭОТАР-Медиа, 2006. - 351 с.
  3. Петров С.Б. Хирургия предстательной железы. - СПб: Изд-во Сергея Ходова, 2004. - 270 с.
  4. Пушкарь Д.Ю., Раснер П.И. Диагностика и лечение локализованного рака предстательной железы. - М.: МЕДпресс-информ, 2008. - 311 с.
  5. Allaf M.E., Palapattu G.S., Trock B.J. et al. Anatomical extent of lymph node dissection: impact on men with clinically localized prostate cancer // J. Urol. - 2004. - Vol. 172. - P. 1840-1844.
  6. Bader P., Burkhard F.C., Markwalder R. et al. Disease progression and survival of patients with positive lymph nodes after radical prostatectomy. Is there a chance of cure? // J. Urol. - 2003. - Vol. 169. - P. 849-854.
  7. Bray F., Lortet-Tieulent J., Ferlay J. et al. Prostate cancer incidence and mortality trends in 37 European countries: an overview // Eur. J. Cancer. - 2010. - Vol. 46. - P. 3040-3052.
  8. Brendler C., Cleeve L., Anderson E. et al. Staging pelvic lymphadenectomy for carcininoma of the prostate: risk versus benefit // Urology. - 1980. - Vol. 124. - P. 849-850.
  9. Briganti A., Blute M.L., Eastham J.H. et al. Pelvic lymph node dissection in prostate cancer // Eur. Urol. - 2009. - Vol. 55. - P. 1251-1265.
  10. Campell S.C., Klein E.A., Levin H.S. et al. Open pelvic lymph node dissection for prostate cancer: a reassessment // Urology. - 1995. - Vol. 46. - P. 352-361.
  11. Catalona W.J., Miller D.R., Kavoussi L.R. Intermediate-term survival results in clinically understaged prostate cancer patients following radical prostatectomy // Urology. - 1988. - Vol. 140. - P. 540-543.
  12. Сheng C.W., Bergstralh E.J., Zincke H. Stage D1 prostate cancer. A nonrandomized comparison of conservative treatment options versus radical prostatectomy // Cancer. - 1993. - Vol. 71. - P. 996-1008.
  13. Cheng L., Zincke H., Blute M.L. et al. Risk of prostate carcinoma death in patients with lymph node metastasis // Cancer. - 2001. - Vol. 91. - Р. 66-73.
  14. D’Amico A.V., Whittington R., Malkowicz S.B. et al. Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer // JAMA. - 1998. - Vol. 280. - P. 969-974.
  15. Danella J.F., deKernion J.B., Smith R.B. et al. The contemporary incidence of lymph node metastases in prostate cancer: implications for laparoscopic lymph node dissection // Urol. - 1993. - Vol. 149. - P. 1488-1503.
  16. Donohue R.E., Mani J.H., Whitesel J.A. et al. Intraoperative and erly complications of staging pelvic lymph node dissection in prostatic adenocarcinoma // Urology. - 1990. - Vol. 35. - P. 223-230.
  17. Grossfeld G.D., Chang J.J., Broering J.M. et al. Under staging and under grading in a contemporary series of patients undergoing radical prostatectomy: results from the cancer of the prostate strategic urologic research endeavor database // Urology. - 2001. - Vol. 165. - P. 851-856.
  18. Han M., Partin A.W., Pound C.R. et al. Long-term biochemical disease-free and cancer-specific survival following anatomic radical retropubic prostatectomy. The 15-year Johns Hopkins experience // Urol. Clin. N. Am. - 2001. - Vol. 28. - P. 555-565.
  19. Heidenreich A., Bellmunt J., Bolla M. et al. EAU guidelines on prostate cancer, I: screening, diagnosis, and treatment of clinically localised disease // Eur. Urol. - 2011. - Vol. 59. - P. 61-71.
  20. Heidenreich A., Ohlmann C.H., Polyakov S. Anatomical extent of pelvic lymphadenectomy in patients undergoing radical prostatectomy // Eur. Urol. - 2007. - Vol. 52. - P. 29-37.
  21. Ji J., Yuan H., Wang L., Hou J. Is the impact of the extent of lymphadenectomy in radical prostatectomy related to the disease risk? A single center prospective study // J. Surg. Res. - 2012. - Vol. 178. - P. 779-784.
  22. Joslyn S.A., Konety B.R. Impact of extent of lymphadenectomy on survival after radical prostatectomy for prostate cancer // Urology. - 2006. - Vol. 68. - P. 121-125.
  23. Kattan M.W., Eastham J.A., Stapleton A.M. et al. A preoperative nomogram for disease recurrence following radical prostatectomy for prostate cancer // J. Natl. Cancer Inst. - 1998. - Vol. 90. - P. 766-771.
  24. Liedberg F., Kjolhede H., Sundqvist P. Laparoscopic extended pelvic lymphadenectomy for staging can be performed with limited morbidity and short hospital stay in patients with prostate cancer // Scand. J. Urol. Nephrol. - 2012. - Vol. 46. - P. 332-336.
  25. Parra R.O., Isorna S., Perez M.G. et al. Radical perineal prostatectomy without pelvic lymphadenectomy: selection criteria and early results // Urology. - 1996. - Vol. 155. - P. 612-625.
  26. Partin A.W., Yoo J., Carter H.B. et al. The use of prostate specific antigen, clinical stage and Gleason score to predict pathological stage in men with localized prostate cancer // Urology. - 1993. - Vol. 150. - P. 110-114.
  27. Partin A.W., Kattan M.W., Subong E.N. et al. Combination of prostate-specific antigen, clinical stage, and Gleason score to predict pathological stage of localized prostate cancer. A multi-institutional update // JAMA. - 1997. - Vol. 277. - P. 1445-1451.
  28. Partin A.W., Mangold L.A., Lamm D.M. et al. Contemporary update of prostate cancer staging nomograms (Partin Tables) for the new millennium // Urology. - 2001. - Vol. 58. - P. 843-848.
  29. Schroder F.H., Hugosson J. Prostate cancer mortality at 11 years of follow up. ERSPC Investigators // N. Engl. J. Med. - 2012. - Vol. 366. - P. 981-987.
  30. Schumacher M.C., Burkhard F.C., Thalmann G.N. et al. Is pelvic lymph node dissection necessary in patients with a serum PSAo10 ng/ml undergoing radical prostatectomy for prostate cancer? // Eur. Urol. - 2006. - Vol. 50. - P. 272-279.
  31. Schwerfeld-Bohr J., Kaemper M., Krege S., Heidenreich A. Prospective randomized multicenter study comparing limited vs extended pelvic lymphadenectomy in intermediate and high risk prostate cancer-first descriptive results (SEAL, AUO AP 55/09) // Eur. Urol. Suppl. - 2014. - Vol. 13. - P. 747.
  32. Siegel R., Ma J., Zou Z. et al. Cancer statistics, 2014. CA // Cancer J. Clin. - 2014. - Vol. 64, N 1. - P. 9-29.
  33. Sivalingam S., Oxley J., Probert J.L. et al. Role of pelvic lymphadenectomy in prostate cancer management // Urology. - 2007. - Vol. 69. - P. 203-209.
  34. Suardi N., Larchera A., Haese A. et al. Indication for and Extension of Pelvic Lymph Node Dissection During Robot-assisted Radical Prostatectomy: An Analysis of Five European Institutions // Eur. Urol. - 2014. - Vol. 66, Iss. 1. - P. 635-643.
  35. Weingartner K., Ramaswamy A., Bittinger A. et al. Anatomical basis for pelvic lymphadenectomy in prostate cancer: results of an autopsy study and implications for the clinic // J. Urol. - 1996. - Vol. 156. - P. 1969-1971.

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