Electrophysiological methods for the diagnosis of disorders of neuromuscular transmission in acute poisoning with organophosphorus compounds


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Abstract

The article presents the results of an experimental study of neuromuscular transmission disorders caused by acute poisoning with a model organophosphorus compound dimethoate. In order to diagnose synaptic transmission disorders, methods of single and rhythmic stimulation electromyography were applied. It was found that the most characteristic and early EMG signs of acute poisoning with organophosphorus compounds are repeated M - responses and the phenomenon of decrement - increment during rhythmic stimulation with a frequency of 10-30 Hz. The diagnostic sensitivity of high - frequency rhythmic stimulation is higher than the routine technique used at a stimulation frequency of 3 Hz. Organophosphorus - induced synaptic transmission disorders are due to cholinergic hyperreactivity and prolonged activation of H - cholinergic receptors. The results of this study can be used both in the diagnosis of poisoning by unknown poisons, and to establish the fact of violation of neuromuscular transmission and assess its severity during intoxication with organophosphorus compounds.

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About the authors

M. A Tyunin

State Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation

Email: gniiivm_7@mil.ru
St. Petersburg, Russia

N. S Ilinskii

State Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation

St. Petersburg, Russia

A. S Gogolevskii

State Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation

St. Petersburg, Russia

E. G Kruchinin

State Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation

St. Petersburg, Russia

V. D Gladkikh

«Farmzaschita» of the Federal Medical and Biological Agency of the Russian Federation

Moscow, Russia

V. A Matseichik

The 27th Scientific Center of the Ministry of Defense of the Russian Federation

Moscow, Russia

M. O Matrosova

State Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation

St. Petersburg, Russia

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Copyright (c) 2020 Tyunin M.A., Ilinskii N.S., Gogolevskii A.S., Kruchinin E.G., Gladkikh V.D., Matseichik V.A., Matrosova M.O.


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