Prospects for the use of biomarkers for the diagnosis of acute respiratory distress syndrome (literature review)


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Abstract

The results of the analysis of literature data on the problem of diagnosis and prediction of the course of acute respiratory distress syndrome of various etiologies are presented. The relevance of research in this area is determined by the high prevalence of severe respiratory distress syndrome development as a non - specific complication of many diseases and injuries in peacetime and wartime. Considering etiological factors, the most informative biomarkers of lung tissue damage were significant for early diagnosis and prediction of the syndrome’s course. As a promising direction, the development of a diagnostic multi - marker panel is substantiated, which allows assisting at the stages of medical evacuation to study critical levels of interleukin-6, interleukin-8, angiopoietin-2, vascular endothelial growth factor, the soluble form of the receptor for the final glycosylation products, and surfactant protein D, as well as markers of endothelial glycocalyx destruction and hemostatic system dysfunction. The variety of etiological factors causing acute respiratory distress syndrome indicates the need to continue the search for biomarkers with the highest diagnostic and prognostic significance.

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About the authors

V. A Pugach

The State Scientific Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation

St. Petersburg, Russia

M. A Tyunin

The State Scientific Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation

St. Petersburg, Russia

N. S Ilinskii

The State Scientific Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation

St. Petersburg, Russia

A. S Gogolevskii

The State Scientific Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation

Email: gniiivm_7@mil.ru
St. Petersburg, Russia

K. I Taborskaya

The State Scientific Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation

St. Petersburg, Russia

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Copyright (c) 2020 Pugach V.A., Tyunin M.A., Ilinskii N.S., Gogolevskii A.S., Taborskaya K.I.


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