Features of the development of antibacterial immune response and chemokines
- Authors: Moskalev A.V1, Gumilevskii B.Y.1, Andreev V.A1
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Affiliations:
- The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation
- Issue: Vol 341, No 12 (2020)
- Pages: 40-46
- Section: Articles
- URL: https://journals.eco-vector.com/0026-9050/article/view/82391
- DOI: https://doi.org/10.17816/RMMJ82391
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Abstract
The article discusses the main features of the development of an antibacterial immune response with chemokines’ participation. The evolutionary changes in the mutual influence of cells carrying out bacterial phagocytosis are reflected. It has been established that one of the critical links of phagocytosis is the interaction of cells of the monocytic - phagocytic system (neutrophils, monocytes, macrophages) with endothelial cells, which is carried out through the production of cytokines - chemokines and ensures the development of the phase of strong adhesion of neutrophils and overcoming the transendothelial barrier. Many bacteria prevent the development of phagocytosis by disrupting the chemokine system’s work due to the production of proteases. Bacterial proteases also act on intracellular signaling pathways, which inactivates the activity of cells of the monocytic - phagocytic system. The listed intimate mechanisms ultimately contribute to the development of incomplete phagocytosis and the accelerated apoptotic death of phagocytes.
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About the authors
A. V Moskalev
The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation
Email: alexmav195223@yandex.ru
St. Petersburg, Russia
B. Yu Gumilevskii
The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian FederationSt. Petersburg, Russia
V. A Andreev
The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian FederationSt. Petersburg, Russia
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).