Assessment of the status of small subpopulations of T-lymphocytes in various immunemediated diseases


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Abstract

The chronic immuno - inflammatory syndrome causes many pathological conditions, including chronic persistent viral diseases and sepsis. An objective assessment of the cellular component of immunity is necessary for adequate management of patients and evaluation of the effectiveness of treatment. To assess the change in the cellular immunity link for various immune - mediated diseases, the immunogram indices of 3 groups of patients were studied: 1st - with chronic herpetic infection, 2nd - with a combination of chronic herpetic infection and Epstein - Barr virus infection, 3rd - with sepsis. As a result, in the 1st group, an imbalance in the ratio of Th1 and Th2 towards the prevalence of Th1 was registered; in the 2nd and 3rd groups of patients, a pronounced predominance of Th2 subpopulation of T - lymphocytes was revealed. A distinctive feature of the immunograms of patients in the 2nd group was an increased content of Treg cells, and in the 3rd group, there was an obvious deficiency of B - lymphocytes (p<0.05).

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About the authors

E. V Markelova

Pacific State Medical University of the Ministry of Health of the Russian Federation

Email: markev2010@mail.ru
Vladivostok, Russia

S. V Knysh

Pacific State Medical University of the Ministry of Health of the Russian Federation

Vladivostok, Russia

V. A Malkov

Pacific State Medical University of the Ministry of Health of the Russian Federation

Vladivostok, Russia

V. A Lazanovich

Pacific State Medical University of the Ministry of Health of the Russian Federation

Vladivostok, Russia

V. B Shumatov

Pacific State Medical University of the Ministry of Health of the Russian Federation

Vladivostok, Russia

A. V Ershov

I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation; Federal Scientific and Clinical Center for Resuscitation and Rehabilitation

Moscow, Russia

S. A Karpitskaya

the A.A.Vishnevsky 3rd Central Military Clinical Hospital of the Ministry of Defense of the Russia Federation

Email: sfijakul@rambler.ru
Odintsovo, Moscow region, Russia

A. F Sukhoterin

the A.A.Vishnevsky 3rd Central Military Clinical Hospital of the Ministry of Defense of the Russia Federation

Odintsovo, Moscow region, Russia

R. I Il’ichev

the A.A.Vishnevsky 3rd Central Military Clinical Hospital of the Ministry of Defense of the Russia Federation

Odintsovo, Moscow region, Russia

A. V Gusev

the A.A.Vishnevsky 3rd Central Military Clinical Hospital of the Ministry of Defense of the Russia Federation

Odintsovo, Moscow region, Russia

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Copyright (c) 2020 Markelova E.V., Knysh S.V., Malkov V.A., Lazanovich V.A., Shumatov V.B., Ershov A.V., Karpitskaya S.A., Sukhoterin A.F., Il’ichev R.I., Gusev A.V.


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