Antimicrobial action of the peptide pentadefenine

The article discusses the problems associated with the acquired resistance of microorganisms that cause purulent - septic complications in patients treated in hospitals. The spectrum of causative agents of hospital infections in the clinics of the Military Medical Academy is shown. The advantages and directions of the application of antiseptics created based on nanotechnology are presented. The study of the antimicrobial activity of pentadefenine, a synthetic analog of the natural peptide indolicidine, against the most significant causative agents of pyoinflammatory infections was carried out. The determination was carried out by the method of serial dilution in a nutrient medium containing microorganisms. We used a standard technique with minor modifications developed, considering the specifics of the study of antimicrobial peptides. The drug’s property has been established to actively suppress multidrug - resistant hospital strains of microorganisms, which makes it promising for topical use in surgery.

causative agents of purulent-septic infections, nano-antiseptics, peptides, pentadefenine, use in surgery