Histological and immunohistochemical changes in the skin of the face, developing as a result of the effects of combined laser radiation

In order to assess pathological changes in the skin after exposure to the combined Er:YAG and Nd:YAG laser, 15 patients (3 men and 12 women) aged 38 to 66 years were examined with signs of aging of the skin of the face and neck (Fitzpatrick phototype I-III). Two procedures of combined (erbium and neodymium) laser irradiation were carried out on the Fotona SP Dynamis apparatus according to the Fotona 4D technique with an interval of 1 month. Skin biopsy was performed on all patients at the screening and 2 months after the start of the study. Histological examination after laser exposure showed an increase in the thickness of the epidermis, an increase in the number of capillaries in the dermis. Immunohistochemical methods revealed increased expression of the CD34 antigen in the zones of newly formed vessels, as well as an increase in the number and density of collagen fibers. Combined laser radiation showed a high efficiency of remodeling of the skin of the face and neck.

age-related skin changes, laser therapy, erbium and neodymium lasers, Er:YAG and Nd:YAG, skin biopsy, histological and immunohistochemical changes of the skin