Regenerative activity of a skin burn wound under the influence of vilon and collagen dissolution products
- 作者: Isakova T.P.1, Obydenko V.I.2, Bayaskhalanova T.B.2, Zagalaev B.T.1, Obydenko Y.N.1
-
隶属关系:
- 321st Military Clinical Hospital of the Ministry of Defense of the Russian Federation
- Chita State Medical Academy of the Ministry of Health of the Russian Federation
- 期: 卷 344, 编号 9 (2023)
- 页面: 72-74
- 栏目: Brief articles
- URL: https://journals.eco-vector.com/0026-9050/article/view/630195
- DOI: https://doi.org/10.52424/00269050_2023_344_9_72
- ID: 630195
如何引用文章
开放存取
##reader.subscriptionAccessGranted##
详细
Objective: to evaluate the effect of a local drug on the reparative regeneration of a burn wound in rats – a collagen dissolution product based on a fermented milk complex and Vilon dipeptide immunomodulator.
After modeling the burn wound, the animals were divided into 3 groups: the 1st group received applications of the collagen dissolution product for 7 days, the 2nd group was administered Vilon at a dose of 0.1 mg/kg of body weight daily during this period, the 3rd group was the control group. Observation of the dynamics of the wound surface, morphological study of the wound surface was carried out on the 1st, 14th, and 21st days. The stimulating effect of both drugs on the reparative regeneration of the burn wound was established. This, compared with the control, was manifested by earlier terms of scab rejection and a reduction in the wound, a more active transition from the inflammatory phase to the proliferative one, and the formation of a full-fledged regenerate with skin derivatives. Differences in the cellular component were revealed: the use of the collagen dissolution product stimulated the mast cell component and had a stimulating effect on repair through the regulation of local homeostasis; under the Vilon influence of, lymphocytes predominated in regeneration, which may indicate the involvement of immune mechanisms.
全文:
作者简介
T. Isakova
321st Military Clinical Hospital of the Ministry of Defense of the Russian Federation
编辑信件的主要联系方式.
Email: isakovatanysha@mail.ru
俄罗斯联邦, Chita
V. Obydenko
Chita State Medical Academy of the Ministry of Health of the Russian Federation
Email: isakovatanysha@mail.ru
俄罗斯联邦, Chita
Ts. Bayaskhalanova
Chita State Medical Academy of the Ministry of Health of the Russian Federation
Email: isakovatanysha@mail.ru
俄罗斯联邦, Chita
B. Zagalaev
321st Military Clinical Hospital of the Ministry of Defense of the Russian Federation
Email: isakovatanysha@mail.ru
俄罗斯联邦, Chita
Yu. Obydenko
321st Military Clinical Hospital of the Ministry of Defense of the Russian Federation
Email: isakovatanysha@mail.ru
俄罗斯联邦, Chita
参考
- Денисов А.В., Бадалов В.И., Крайнюков П.Е., Гончаров А.В., Маркевич В.Ю. и др. Структура и характер современной боевой хирургической травмы // Воен.-мед. журн. – 2021. – Т. 342, № 9. – С. 12–20.
- Зиновьев Е.В., Крайнюков П.Е., Асадулаев М.С. и др. Экспериментальная оценка эффективности применения адипогенных мезенхимальных стволовых клеток для лечения ожогов кожи III степени // Вестн. Рос. воен.-мед. акад. – 2017. – № 1. – С. 137–141
- Костяков Д.В., Зиновьев Е.В., Арцимович И.В. и др. Результаты экспериментального исследования эффективности применения биомедицинских клеточных продуктов на основе аллогенных фибробластов при лечении ожогов кожи // Журн. Неотложная Хирургия им. И.И.Джанелидзе. – 2021. – № S1. – С. 36–37.
- Крайнюков П.Е., Арцимович И.В., Зиновьев Е.В. и др. Применение клеточных технологий в лечении ран различной этиологии // Вестн. Национ. мед.-хир. центра им. Н.И.Пирогова. – 2021. – Т. 16, № 2. – С. 132–137.
- Хавинсон В.Х. Лекарственные пептидные препараты: прошлое, настоящее, будущее // Клин. медиц. – 2020. – Т. 98, № 3. – С. 165–177.
- Шалбуев Д.В., Тумурова Т.Б. Патент № 2715639 C1 РФ. Способ получения биоактивного коллагенового продукта: заявл. 04.07.2019; опубл. 02.03.2020. – 8 с.
- Шруб П.М. Статистика ожоговых травм в военных конфликтах / Проблемы и перспективы развития современной медицины: Сб. науч. ст. IX Респ. науч.-практ. конф. с междунар. участ., Гомель, 28.04.2017. – Гомель: ГомГМУ, 2017. – C. 842–844.
补充文件
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).