Regenerative activity of a skin burn wound under the influence of vilon and collagen dissolution products

Objective: to evaluate the effect of a local drug on the reparative regeneration of a burn wound in rats – a collagen dissolution product based on a fermented milk complex and Vilon dipeptide immunomodulator.

After modeling the burn wound, the animals were divided into 3 groups: the 1st group received applications of the collagen dissolution product for 7 days, the 2nd group was administered Vilon at a dose of 0.1 mg/kg of body weight daily during this period, the 3rd group was the control group. Observation of the dynamics of the wound surface, morphological study of the wound surface was carried out on the 1st, 14th, and 21st days. The stimulating effect of both drugs on the reparative regeneration of the burn wound was established. This, compared with the control, was manifested by earlier terms of scab rejection and a reduction in the wound, a more active transition from the inflammatory phase to the proliferative one, and the formation of a full-fledged regenerate with skin derivatives. Differences in the cellular component were revealed: the use of the collagen dissolution product stimulated the mast cell component and had a stimulating effect on repair through the regulation of local homeostasis; under the Vilon influence of, lymphocytes predominated in regeneration, which may indicate the involvement of immune mechanisms.