Multiple sclerosis vaccine: possibilities of the use of dendritic cells immunomodulatory potential


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For the first time we carried out a clinical assessment of the safety, tolerability and clinical efficacy course of repeated administration of experimental modified autologous vaccine interlеykin (IL-10) dendritic cells in two patients with secondary-progressive multiple sclerosis patient and one with relapsing-remitting multiple sclerosis. In the course of treatment, we carried out clinical and immunological monitoring. It was found out that intradermal dose of 3 ґ 106 cells applied to spinal area 6-12 times did not cause any serious side effects. After the treatment with dendritic cells the following results were observed: 1) a significant positive clinical effect in patients with secondary-progressive multiple sclerosis exacerbations; 2) moderate positive clinical effect in patients with relapsing-remitting multiple sclerosis, in a state of remission; 3) a complete absence of any clinical results in patients with secondary-progressive multiple sclerosis without exacerbations. The immune response was characterized by a significant absolute and relative increase of serum T-regulatory cells. Discovered distinct anti-inflammatory properties of dendritic cell therapy allow us to consider it as a promising area of personalized treatment based on an individual vaccination against multiple sclerosis.

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版权所有 © Odinak M.M., Bisaga G.N., Chirskii V.S., Pashchenkov M.V., Baldueva I.A., Moiseenko V.M., Nekhaeva T.L., Kalinina N.M., Davydova N.I., Bychkova N.V., Pozdnyakov A.V., 2016


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