Complex characteristics of clinical, pathological and microbiological features of ulcerative colitis

The results of a comprehensive examination of 46 patients with ulcerative colitis are presented. In 25 patients, a histomorphologic and microbiological study of biopsy specimens of the colon wall was performed. Morphological signs of ulcerative colitis were present in 24 patients, in one case Crohn’s disease was diagnosed. The full range of diagnostic signs characteristic of ulcerative colitis was determined in 19 patients. In 50% of cases, a pronounced activity of the inflammatory process was observed, in 30% - moderate, in 20% - its minimum degree. In patients with moderate and severe inflammation in biopsy specimens, in 70.9% of cases, Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Aeromonas hydrophyes and mixed infection were detected. In patients with moderate and severe disease, the course of treatment, considering the results of tests on the microflora, was supplemented with antibacterial therapy. The above complex characteristic of ulcerative colitis shows the need for a microbiological study of biopsy specimens of the intestinal wall of patients, which makes it possible to choose antibacterial chemotherapeutic agents with proven efficacy against the identified microorganism.

inflammatory bowel diseases, ulcerative colitis, histomorphologic and microbiological features, complex therapy