Modern biomarkers in the diagnosis of acute respiratory infections of the upper respiratory tract and determining the strategy of antibiotic therapy (review of foreign literature)


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In the treatment of bacterial infections of the upper respiratory tract, the leading role is played by antibiotic therapy, and determining the indications for its purpose, volume, and duration is a predictor of the success of the treatment. The effectiveness and adequacy of antibiotic therapy are determined by the timeliness and accuracy of differential diagnosis between viral and bacterial etiology of infection. The absence of a «gold standard» for differential diagnosis determines an increased interest in finding biomarkers that can solve this diagnostic problem, as well as formulating strategies for using antibacterial drugs based on the results of a quantitative assessment of serum biomarkers (biomarker-mediated antibacterial therapy). The article presents data from foreign literature on the results of studies and meta-analyses of the diagnostic value of C-reactive protein, procalcitonin, neopterin, and defensins to optimize biomarker-mediated antibacterial therapy for acute respiratory infections of the upper respiratory tract.

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