Electrophysiological methods for the diagnosis of disorders of neuromuscular transmission in acute poisoning with organophosphorus compounds


如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅存取

详细

The article presents the results of an experimental study of neuromuscular transmission disorders caused by acute poisoning with a model organophosphorus compound dimethoate. In order to diagnose synaptic transmission disorders, methods of single and rhythmic stimulation electromyography were applied. It was found that the most characteristic and early EMG signs of acute poisoning with organophosphorus compounds are repeated M - responses and the phenomenon of decrement - increment during rhythmic stimulation with a frequency of 10-30 Hz. The diagnostic sensitivity of high - frequency rhythmic stimulation is higher than the routine technique used at a stimulation frequency of 3 Hz. Organophosphorus - induced synaptic transmission disorders are due to cholinergic hyperreactivity and prolonged activation of H - cholinergic receptors. The results of this study can be used both in the diagnosis of poisoning by unknown poisons, and to establish the fact of violation of neuromuscular transmission and assess its severity during intoxication with organophosphorus compounds.

全文:

受限制的访问

作者简介

M. Tyunin

State Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation

Email: gniiivm_7@mil.ru
St. Petersburg, Russia

N. Ilinskii

State Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation

St. Petersburg, Russia

A. Gogolevskii

State Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation

St. Petersburg, Russia

E. Kruchinin

State Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation

St. Petersburg, Russia

V. Gladkikh

«Farmzaschita» of the Federal Medical and Biological Agency of the Russian Federation

Moscow, Russia

V. Matseichik

The 27th Scientific Center of the Ministry of Defense of the Russian Federation

Moscow, Russia

M. Matrosova

State Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation

St. Petersburg, Russia

参考

  1. Бурцева Н.И., Тюнин М.А., Гоголевский А.С. и др. Оценка риска формирования промежуточного синдрома при отравлениях фосфорорганическими соединениями с использованием молекулярного докинга // Биомедицина. - 2017. - № 3. - С. 40-59.
  2. Луис Д., Ричард Ф. К., Тимоти Б. и др. Секреты токсикологии / Пер. с англ. - М.; СПб.: БИНОМ, 2006. - 376 с.
  3. Николаев С.Г. Электромиография: клинический практикум. - Иваново: ПресСто, 2013. - 394 с.
  4. De Cauwer H., Somville F.J., Joillet M. et al. Neurological aspects of chemical and biological terrorism: guidelines for neurologists // Acta Neurologica Belgica. - 2017. - Vol. 117, N 3 - P. 603-611.
  5. Dongren Y., Tao L., Fengsheng H. Electroneurophysiological studies in rats of acute dimethoate poisoning // Toxicology letters. - 1999. - Vol. 107, N 1-3. - P. 249-254.
  6. Good J.L., Khurana R.K., Mayer R.F. et al. Pathophysiological studies of neuromuscular function in subacute organophosphate poisoning induced by phosmet // Journal of Neurology, Neurosurgery & Psychiatry. - 1993. - Vol. 56, N 3. - P. 290-294.
  7. Handbook of toxicology of chemical warfare agents / Ed. by R. Gupta. - San Diego: Elsevier, 2015. - 1184 p.
  8. Jayawardane P., Dawson A. H., Weerasinghe V. et al. The spectrum of intermediate syndrome following acute organophosphate poisoning: a prospective cohort study from Sri Lanka // PLoS medicine. - 2008. - Vol. 5, N 7. - P. 1143-1153.
  9. Juel V. C. Evaluation of neuromuscular junction disorders in the electromyography laboratory // Neurologic clinics. - 2012. - Vol. 30, N 2. - P. 621-639.
  10. Karami-Mohajeri S., Nikfar S., Abdollahi M. A systematic review on the nerve-muscle electrophysiology in human organophosphorus pesticide exposure // Human & experimental toxicology. - 2014. - Vol. 33, N 1. - P. 92-102.
  11. Maselli R., Jacobsen J. H., Spire J. P. Edrophonium: an aid in the diagnosis of acute organophosphate poisoning // Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society. - 1986. - Vol. 19, N 5. - P. 508-510.
  12. Singh G., Avasthi G., Khurana D. et al. Neurophysiological monitoring of pharmacological manipulation in acute organophosphate (OP) poisoning. The effects of pralidoxime, magnesium sulphate and pancuronium // Electroencephalography and clinical neurophysiology. - 1998. - Vol. 107, N 2. - P. 140-148.

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Tyunin M.A., Ilinskii N.S., Gogolevskii A.S., Kruchinin E.G., Gladkikh V.D., Matseichik V.A., Matrosova M.O., 2020


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: № 01975 от 30.12.1992.
##common.cookie##