Clinical and pathomorphological characteristics of a meningococcal infection with a fatal outcome in young people


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Abstract

To increase the efficiency of medical care for patients with a generalized form of meningococcal infection, clinical manifestations, and pathomorphological changes in young people with a fatal outcome of the disease have been studied. The main clinical form was meningococcemia with fulminant development. The disease was characterized by a sudden onset, rapid progression of typical symptoms: chills, febrile fever, headache, and myalgia. Signs of the development of septic shock were severe hypotension, often vomiting and loose stools. Hemorrhagic exanthema was always detected on the first day of meningococcemia, in some patients - 4-6 hours after the early symptoms. The leading complications and critical conditions in almost all patients with meningococcemia were a septic shock, disseminated intravascular coagulation, and acute adrenal insufficiency. The immediate cause of death was a septic shock (97.1%), in one case, necrotic meningoencephalitis. The timeliness of identifying the first manifestations of a generalized form of meningococcal infection, the provision of emergency care at the prehospital stage, and the speedy hospitalization contribute to maintaining life and health in this category of patients.

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About the authors

K. V Zhdanov

The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

Email: zhdanovkv@rambler.ru
St. Petersburg, Russia

A. N Kovalenko

The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

St. Petersburg, Russia

V. S Chirskii

The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

St. Petersburg, Russia

S. M Zakharenko

The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

St. Petersburg, Russia

N. A Nalivkina

The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

St. Petersburg, Russia

V. V Sharabkhanov

The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

St. Petersburg, Russia

K. S Ivanov

The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

St. Petersburg, Russia

M. K Shishkin

The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

St. Petersburg, Russia

M. V Yaremenko

The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

St. Petersburg, Russia

R. A Khairutdinova

The S.M.Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

St. Petersburg, Russia

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Copyright (c) 2020 Zhdanov K.V., Kovalenko A.N., Chirskii V.S., Zakharenko S.M., Nalivkina N.A., Sharabkhanov V.V., Ivanov K.S., Shishkin M.K., Yaremenko M.V., Khairutdinova R.A.


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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