2020 Nobel Prize Laureates In Physiology or Medicine: Harvey J.Alter, Michael Houghton, and Charles M.Rice
- Autores: Ivanov A.V1
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Afiliações:
- Engelhardt Institute of Molecular Biology, RAS
- Edição: Nº 12 (2020)
- Páginas: 67-71
- Seção: Articles
- URL: https://journals.eco-vector.com/0032-874X/article/view/627942
- DOI: https://doi.org/10.7868/S0032874X2012008X
- ID: 627942
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Resumo
The Nobel Prize in Physiology or Medicine 2020 was awarded jointly to three scientists: Harvey J.Alter, Michael Houghton, and Charles M.Rice “for the discovery of Hepatitis C virus”. This decision highlighted the importance of the discovery and research of a dangerous and widespread human pathogen, which led to the creation of highly effective drugs.
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Sobre autores
A. Ivanov
Engelhardt Institute of Molecular Biology, RAS
Email: aivanov@eimb.ru
Moscow, Russia
Bibliografia
- Alter H.J., Holland P.V., Morrow A.G. et al. Clinical and serological analysis of transfusion-associated hepatitis. Lancet. 1975; 2(7940): 838–841. doi: 10.1016/s0140-6736(75)90234-2.
- Alter H.J., Purcell R.H., Holland P.V., Popper H. Transmissible agent in non-A, non-B hepatitis. Lancet. 1978; 1(8062):459–463. doi: 10.1016/s0140-6736(78)90131-9.
- Choo Q.L., Kuo G., Weiner A.J. et al. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science. 1989; 244(4902): 359–362. doi: 10.1126/science.2523562.
- Kolykhalov A.A., Agapov E.V., Blight K.J. et al. Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA. Science. 1997; 277(5325): 570–574. doi: 10.1126/science.277.5325.570.
- Lohmann V., Körner F., Koch J. et al. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science. 1999; 285(5424):110–113. doi: 10.1126/science.285.5424.110.
- Bartosch B., Dubuisson J., Cosset F.L. Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes. J. Exp. Med. 2003;197(5): 633–642. doi: 10.1084/jem.20021756.
- Wakita T., Pietschmann T., Kato T. et al. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat. Med. 2005; 11(7): 791–796. doi: 10.1038/nm1268.
- Lindenbach B.D., Evans M.J., Syder A.J. et al. Complete replication of hepatitis C virus in cell culture. Science. 2005; 309(5734): 623–626. doi: 10.1126/science.1114016.
- Kapadia S.B., Chisari F.V. Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids. PNAS. 2005; 102(7): 2561–2566. doi: 10.1073/pnas.0409834102.
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