To Clean the Blood with a Polymer Networks: Hypercrosslinked Polystyrene in Cytokine Storm Therapy
- Authors: Davankov V.A1, Tsyurupa M.P1, Pavlova L.A1, Pastukhov A.V1
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Affiliations:
- Nesmeyanov Institute of Organoelement Compounds, RAS
- Issue: No 4 (2021)
- Pages: 3-11
- Section: Articles
- URL: https://journals.eco-vector.com/0032-874X/article/view/627975
- DOI: https://doi.org/10.7868/S0032874X21040013
- ID: 627975
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Abstract
More than half a century ago, we synthesized a polymer with contradictory properties in terms of polymer chemistry, i.e. hypercrosslinked polystyrene. Despite the rigid connection between each chain link with the links of neighboring chains, it turned out to be quite flexible, absorbs large amounts of any liquid, and noticeably increases in size. Currently the production of hypercrosslinked polystyrene sorbents amounts in thousands of tons per year; they are used widely in science and technology. An amazing property of the rigid polymer networks is its complete inertness in relation to blood cells and large protein molecules. This made it possible to create universal hemosorbents based on hypercrosslinked polymers, which have already saved hundreds of patients with general blood poisoning (sepsis). The article describes the stages of creation of these sorbents, which turned out to be so claimed during the current coronavirus pandemic.
About the authors
V. A Davankov
Nesmeyanov Institute of Organoelement Compounds, RAS
Email: davank@ineos.ac.ru
Moscow, Russia
M. P Tsyurupa
Nesmeyanov Institute of Organoelement Compounds, RASMoscow, Russia
L. A Pavlova
Nesmeyanov Institute of Organoelement Compounds, RASMoscow, Russia
A. V Pastukhov
Nesmeyanov Institute of Organoelement Compounds, RASMoscow, Russia
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