2023 Nobel Prize Laureates in Physiology or Medicine: Katalin Karikó and Drew Weissman
- Авторлар: Antropov D.N1, Prokhorova D.V1, Stepanov G.A1
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Мекемелер:
- Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences
- Шығарылым: № 12 (2023)
- Беттер: 64-71
- Бөлім: Articles
- URL: https://journals.eco-vector.com/0032-874X/article/view/627879
- DOI: https://doi.org/10.7868/S0032874X23120086
- ID: 627879
Дәйексөз келтіру
Аннотация
The Nobel Prize in Physiology or Medicine in 2023 was awarded to American researchers Katalin Karikó and Drew Weissman “for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.” The laureates for decades have been searching for strategies to create mRNA-based vaccines and drugs. A method of RNA modification, described by them in 2005, made the creation of mRNA vaccines and mRNA drugs possible. The resulted technology made it possible to use mRNA as a tool for delivering genetic information into cells and into the body. This breakthrough became the basis for the creation of mRNA-based vaccines, which have shown high effectiveness in the fight against infectious diseases and opened the prospect of creating individual anti-cancer mRNA vaccines. The work of Katalin Karikó and Drew Weissman formed the basis of the most widespread vaccines against COVID-19 from Pfizer/BioNTech and Moderna. Although the latest pandemic facilitated creation of a whole set of eff ective vaccines (for example, Sputnik-V), the mRNA vaccines are considered the most innovative and technologically advanced.
Негізгі сөздер
Авторлар туралы
D. Antropov
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of SciencesNovosibirsk, Russia
D. Prokhorova
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of SciencesNovosibirsk, Russia
G. Stepanov
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences
Email: i@stepanovga.ru
Novosibirsk, Russia
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