2021 Nobel Prize Laureates in Physiology or Medicine: David Julius and Ardem Patapoutian

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Resumo

The Nobel Prize in Physiology or Medicine 2021 was awarded to American scientists David Julius and Ardem Patapoutian “for their discoveries of receptors for temperature and touch”. These receptors are actually cationic Ca2+-permeable channels that detect thermal or mechanical disturbances of the cell membrane and convert them into changes in membrane potential and intracellular Ca2+ concentration. The article discusses the retrospective aspects of the research and its key results, which have been so highly praised by the Nobel Committee.

Sobre autores

S. Kolesnikov

Institute of Cell Biophysics, RAS

Email: staskolesnikov@yahoo.com
Pushchino, Moscow Oblast

Bibliografia

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  24. Murthy S.E., Loud M.C., Daou I., … Patapoutian A. The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice. Sci. Transl. Med. 2018; 10(462): eaat9897. doi: 10.1126/scitranslmed.aat9897.
  25. Woo S.H., Lukacs V., de Nooij J.C., … Patapoutian A. Piezo2 is the principal mechanotransduction channel for proprioception. Nat. Neurosci. 2015; 18(12): 1756–1762. doi: 10.1038/nn.4162.
  26. ZengW.Z., Marshall K.L., Min S., … Patapoutian A. PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex. Science. 2018; 362 (6413): 464–467. doi: 10.1126/science.aau6324.

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