Impact of bioregulation therapy on the course of retinitis pigmentosa in older people
- Authors: Trofimova S.V1, Datseris Y.2, Trofimov A.V3, Diamanti R.2
-
Affiliations:
- Saint Petersburg Institute of Bioregulation and Gerontology
- OMMA Ophthalmology Hospital
- OOO «Tree of Life. Clinic»
- Issue: Vol 31, No 6 (2020)
- Pages: 73-75
- Section: Articles
- URL: https://journals.eco-vector.com/0236-3054/article/view/114229
- DOI: https://doi.org/10.29296/25877305-2020-06-14
- ID: 114229
Cite item
Open Access
Access granted
Abstract
The paper presents the results of 30-year clinical use of peptide retinoprotectors in the treatment of degenerative retinal diseases, retinitis pigmentosa in particular. The findings suggest that peptide retinoprotectors have a high clinical effect and that these peptide drugs are promising for use in older people.
Full Text
About the authors
S. V Trofimova
Saint Petersburg Institute of Bioregulation and Gerontology
Email: dr.s.trofimova@gmail.com
Professor
Y. Datseris
OMMA Ophthalmology HospitalMD; Professor thens, Greece
A. V Trofimov
OOO «Tree of Life. Clinic»MD Saint Petersburg
R. Diamanti
OMMA Ophthalmology HospitalMD thens, Greece
References
- Трофимова С.В., Нероева В.В. Влияние ретиналамина на течение пигментной дегенерации сетчатки у лиц пожилого и старческого возраста. Геронтология и гериатрия. 2004; 3: 188-91
- Трофимова С.В., Максимов И.Б., Нероев В.В. Регуляторное действие пептидов сетчатки. СПб: ИКФ «Фолиант», 2004; 160 с.
- Хавинсон В.Х., Линькова Н.С., Проняева В.Е. Методика создания монослоя клеток на базе органотипической культуры для тестирования физио логически активных веществ. Бюлл. экспер. биол. мед. 2012; 2: 759
- Хавинсон В.Х., Проняева В.Е., Линькова Н.С. и др. Пептидергическая регуляция дифференцировка эмбриональных клеток сетчатки. Клеточные технологии в биологии и медицине. 2013; 1: 57-60
- Anisimov V.N., Khavinson V.Kh. Peptide bioregulation of aging: results and prospects. Biogerontology. 2010; 11: 139. doi: 10.1007/s10522-009-9249-8
- Berson E.L., Rosner B., Sandberg M.A. Clinical trial of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment. Arch. Ophthalmol. 2004; 122 (9): 1297-305. doi: 10.1001/archopht.122.9.1297
- Cremers F., Jose A. Molecular genetics of Leber congenital amaurosis. Hum. Molec. Genet. 2002; 11 (10): 1169-76. doi: 10.1093/hmg/11.10.1169
- Datseris Y., Diamanti R., Trofimova S. Results of many years of application of peptide bioregulators in patients with retinitis pigmentosa. In: Book of Abstracts. Proceedings of V European Congress of Preventive, Regenerative and Anti-Aging Medicine, St. Petersburg. September 8-10, 2016. SPb: FlyPrint, 2016; p. 31-2.
- Datseris Y., Diamanti R., Trofimova S. Retinoprotectiv effect of peptide bioregulators in treatment of retinitis pigmentosa. In: Book of Abstracts International symposium of experts «Effective current approaches in anti-aging medicine and gerontology», Sweden, 13-14 April, 2018; p. 30-3.
- Ferrari S., Iorio E., Barbaro V. et al. Retinitis pigmentosa: genes and disease mechanisms. Curr. Genomics. 2011; 1: 238-49. doi: 10.2174/138920211795860107
- Khavinson V. Peptides and Ageing. NeuroEndocrynol. Lett. 2002; 23 (Suppl. 3): 144.
- Khavinson V.Kh., Malinin V.V., Trofimova S.V. et al. Inductive activity of retinal peptides. Bull. Exp. Biol. Med. 2002 (А); 134 (5): 482.
- Khavinson V.Kh., Razumovsky M., Trofimova S. Pineal regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa. NeuroEndocrinol. Lett. 2002 (Б); 23 (4): 365.
- Khavinson V.Kh., Solov’ev A.Yu., Zhilinskii D.V. et al. Epigenetic aspects of peptide mediated regulation of aging. Advances in Gerontology. 2012; 2 (4): 277.
- Khavinson V.Kh., Zemchikhina V.N., Trofimova S.V. et al. Effect of peptides on proliferative activity of retinal and pigmented epithelial cells. Bull. Exp. Biol. Med. 2003; 135 (6): 597.
- Khavinson V.Kh., Malinin V.V. Gerontological Aspects of Genom Peptide Regulation. Basel (Switzerland): Karger AG, 2005; p. 104.
- Takano M. Brain derived neutrophic factor enhances neurite regeneration from retinal ganglion cells in aged human retina in vitro. Exp. Eye Res. 2002; 74 (2): 319-23. doi: 10.1006/exer.2001.1118
- Vanyushin B.F., Khavinson V.Kh. Short Biologically Active Peptides as Epigenetic Modulators of Gene Activity. W. Doerfler, P. Böhm (eds.). Epigenetics - A Different Way of Looking at Genetics. Springer International Publishing Switzerland, 2016; p. 69-90.
Supplementary files
